Clinical trials: Pediatric Cardiology
Congenital Heart Diseases
The Protective Effects of Sevoflurane in Pediatric Cardiac Surgery
During repair of a congenital heart defect the child is exposed to myocardial hypoxia. Recent studies have suggested that the paediatric myocardium is more sensitive to hypoxia and cardioplegic arrest than the adult.
- Trial name
- NCT01450956
- Testing
- Sevoflurane, Control
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Burns, Sedation
Dexmedetomidine Cardiovascular Safety in Pediatric Burn Patients
Dexmedetomidine is a sedative drug approved for adult patients, intubated, in intensive care units. We are studying whether this drug is cardiovascularly safe in pediatric patients who have recently been burned.
- Trial name
- NCT00697788
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Congenital Heart Disease, Sedated for Cardiac Catheterization
Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions
Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions.
- Trial name
- NCT01501786
- Testing
- control, Ket10, Ket20
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Ibaraki Children's Hospital
Congenital Heart Disease
Epidemiology of Congenital Heart Disease in France
Congenital heart disease (CHD) is the leading cause of birth defects, with an incidence of 0.8%. Since the 1980s, France has been a pioneer in neonatal CHD surgery (Pr. Fontan, Pr. Lecomte, Pr.
- Trial name
- EPIDEMIO-CHD (NCT04740177)
- Where
- France
- Volunteers
- 450,000 people
- Sponsor
- University Hospital, Montpellier
Obesity, Childhood, Behavior, Eating
Pediatric Obesity Management Study
Childhood obesity is a critical public health issue. Obesity in childhood is associated with many complications, including high blood pressure, type II diabetes mellitus, abnormal blood lipid values, obstructive sleep apnea…
- Trial name
- NCT05622981
- Testing
- Age-specific educational materials and monitoring
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Corewell Health East
Heart Diseases
B-type Natriuretic Peptide in the Non-Cardiac Pediatric Patient
B-type Natriuretic Peptide (BNP) is a hormone that is made by the pumping chambers of the heart. The BNP level can be measured by a blood test and is used as a marker for heart problems in adults.
- Trial name
- NCT00330811
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Emory University
Pulmonary Vein Stenosis
Predicting Pediatric Pulmonary Vein Stenosis Outcomes Using Data Acquired During a Cardiac Catheterization
This is a prospective, single center study which applies a standardized, comprehensive catheterization assessment to patients with a known or suspected diagnosis of pulmonary vein stenosis (PVS) who are undergoing a cardiac…
- Trial name
- NCT04696289
- Testing
- Standardized catheterization assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston Children's Hospital
Menkes Disease
NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease
This clinical trial will evaluate the safety, tolerability, dosing, and efficacy of Northera (Droxidopa) in children with Menkes disease aged 7 to 17 years who survived the major neurodegenerative and neurocognitive effects of…
- Trial name
- NCT07398508
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stephen G. Kaler
Congenital Heart Disease (CHD), Heart Transplant Patients
Search for Noninvasive Markers of "Graft Injury" in Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Transplantation
This clinical tissue-based, drug-free, single-center, longitudinal study aims to validate a new diagnostic method, namely, to evaluate whether plasma levels of circulating donor free DNA in the recipient's blood (Dd-cfDNA…
- Conditions
- Congenital Heart Disease (CHD), Heart Transplant Patients, Adult Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT06784440
- Testing
- Evaluation of circulating donor free DNA in the recipient's blood (Dd-cfDNA: donor-derived cell free DNA)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pacing Therapy, Postoperative Care
Postoperative Pacing for Cardiac Efficiency
The goal of this study is to determine whether temporarily increasing a child's heart rate after heart surgery can improve blood flow and oxygen supply to the body's tissues.
- Conditions
- Pacing Therapy, Postoperative Care, Pediatric Congenital Heart Surgery, Cardiac Pacing
- Trial name
- POSTPACE (NCT07852390)
- Testing
- Temporary Atrial Pacing
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Robert G. Webster, MD, MPH
Multisystem Inflammatory Syndrome in Children (MIS-C), SARS-CoV-2 Infection
Cardiovascular Assessment 5 Years After MIS-C
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication associated with SARS-CoV-2 infection that frequently affects the cardiovascular system.
- Trial name
- NCT07659847
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Fabry Disease
A Study of Two Fabrazyme (Agalsidase Beta) Dosing Regimens in Treatment-naïve, Male Pediatric Patients Without Severe Symptoms
The purpose of this study was to determine whether 2 alternative dosing regimens of Fabrazyme (Agalsidase beta) (1.0 mg/kg every 4 weeks or 0.5 mg/kg every 2 weeks) were effective in treatment-naïve pediatric participants without…
- Trial name
- FIELD (NCT00701415)
- Testing
- Agalsidase beta
- Where
- 12 sites in United States, Argentina and 7 more
- Volunteers
- 31 people
- Sponsor
- Genzyme, a Sanofi Company
Hereditary Angioedema (HAE)
A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary Angioedema
HGT-FIR-086 is a multicenter, open-label, non-randomized, single-arm study to evaluate the Pharmacokinetics, tolerability,safety, and efficacy on reproductive hormones, of a single subcutaneous (SC) administration of icatibant in…
- Trial name
- NCT01386658
- Testing
- icatibant
- Where
- 26 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Shire
General Anesthesia, Dexmedetomidine
General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients
The aim of the present study is to compare between general anesthesia versus sedation with dexmedetomidine and ketamine with local infilteration at the catheter insertion site in pediatric patients undergoing transcutaneous…
- Conditions
- General Anesthesia, Dexmedetomidine, Ketamine, Local Infiltration
- Trial name
- NCT06431178
- Testing
- General Anesthesia, Local anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Heart Defects, Congenital, Intensive Care Units, Pediatric
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
- Conditions
- Heart Defects, Congenital, Intensive Care Units, Pediatric, Respiration, Artificial, Extubation
- Trial name
- NCT07059689
- Testing
- High Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Indonesia
- Volunteers
- 114 people
- Sponsor
- Universitas Indonesia
Venous Thromboembolism
A Study in the United Sates That Looks at the Safety and Effectiveness of Pradaxa Pellets in Children Aged 3 Months to Less Than 12 Years Who Need Treatment of a Blood Clot or Who Have Had a Blood Clot and Are at Risk of Developing Another Blood Clot
The main research question of this study is to obtain further safety and effectiveness data on Pradaxa Pellets in children aged 3 months to less than 12 years in routine clinical practice setting.
- Trial name
- NCT05966740
- Where
- 10 sites in United States
- Volunteers
- 5 people
- Sponsor
- Boehringer Ingelheim