Clinical trials: Pediatric Critical Illness
Cardiac Output
Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients
The ability to measure cardiac output (CO) accurately and reproducibly at frequent intervals remains elusive to the clinician caring for critically ill pediatric patients even though a large proportion of these children are known…
- Trial name
- GCH (NCT00853437)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Transonic Systems Inc.
Tracheostomy, Endotracheal Tube
Airway Microbiome Changes After Artificial Airway Exchange in Critically-ill Pediatric Patients.
Artificial airways, such as endotracheal tubes and tracheostomies, in the pediatric and neonatal intensive care units (PICU, NICU respectively) are lifesaving for patients in respiratory failure, among other conditions.
- Conditions
- Tracheostomy, Endotracheal Tube, Ventilator Associated Pneumonia, Tracheitis
- Trial name
- NCT06201130
- Testing
- Suctioning of artificial airway
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Arterial Hypotension in Critically Ill Neonatal and Pediatric Patients
Copeptin and Arterial Hypotension in Critically Ill Paediatric and Neonatal Intensive Care Patients
Blood copeptin will be measured during the routine treatment of neonates, children and adolescents on the Intensive Care Unit of the University Children's Hospital Zurich at different time points (admission, 12, 24, 48, 96, 168…
- Trial name
- COPNIC (NCT03320967)
- Testing
- Copeptin in plasma
- Where
- Switzerland
- Volunteers
- 170 people
- Sponsor
- Vincenzo Cannizzaro
Sepsis, Bacteremia
Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically Ill Children
This study will test the hypothesis that reliable implementation of an evidence-based clinical practice guideline for evaluation of patients with signs and symptoms of sepsis will decrease antibiotic use in pediatric intensive…
- Trial name
- Bright STAR (NCT03441126)
- Testing
- Multicenter Quality Improvement program
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Pediatric Critical Illness, Critical Illness
Tissue Penetration of Antibiotics in CriTically Ill Children
This clinical study evaluates the extent to which three commonly administered beta-lactam antibiotics (piperacillin-tazobactam, meropenem, and amoxicillin-clavulanic acid) penetrate tissue in critically ill pediatric patients.
- Trial name
- TACTIC (NCT07822243)
- Testing
- Pharmacokinetic sampling (Microdialysis and blood sampling)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Critical Illness
Use of In-Line Filtration in Critically Ill Children
The purpose of this study is to determine whether the use of in-line filtration shows any effect on the outcome of sepsis, systemic inflammatory response syndrome (SIRS), thrombosis, or organ failure in critically ill children…
- Trial name
- NCT00209768
- Testing
- Filter: NOE96E, ELD96E, NLF1E, TNA1E
- Where
- Germany
- Volunteers
- 821 people
- Sponsor
- Hannover Medical School
Critical Illness
Neuroendocrine Dysfunction in Critically Ill Pediatric Patients
Research studies in adults have shown that certain hormones may be decreased or may not work normally which contributes to how sick a person becomes. The purpose of this project is to study hormones in children.
- Trial name
- NCT00207896
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Children's Healthcare of Atlanta
Sepsis, Shock
Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients
Investigators are conducting research about oxygen levels in the body and whether it is possible to use a device to measure oxygen in the body's tissues noninvasively, without blood draws or a catheter (a plastic tube placed in a…
- Trial name
- NCT01760044
- Testing
- Tissue oxygenation monitoring
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Pediatrics, Intensive Care Unit
Asia Pediatric Intensive Care Epidemiology and Outcomes Study
The overall objective of this study is to improve the standard of care of critically ill pediatric patients. The specific aims are to describe the clinical profile and outcomes of all admissions to Asian pediatric ICUs, determine…
- Conditions
- Pediatrics, Intensive Care Unit, Critical Illness
- Trial name
- AsiaPedIC (NCT06481644)
- Where
- 2 sites in Singapore, Thailand
- Volunteers
- 10,000 people
- Sponsor
- KK Women's and Children's Hospital
Acute Kidney Injury, Renal Replacement Therapy
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI
This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Units
- Trial name
- Taking Focus 2 (NCT03541785)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Delirium
Quetiapine Treatment for Pediatric Delirium
This is a prospective, double-blind, randomized controlled trial to begin determining the efficacy of quetiapine as a treatment for pediatric delirium in patients admitted to the pediatric intensive care unit (PICU)
- Trial name
- NCT03572257
- Testing
- Quetiapine
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Critical Illness, Children
Early Versus Late Parenteral Nutrition in the Pediatric Intensive Care Unit
In the PEPaNIC trial it is investigated whether withholding parenteral nutrition during the first week in critically ill children is beneficial, compared to the current standard of the early start of parenteral nutrition.
- Trial name
- PEPaNIC (NCT01536275)
- Testing
- Late parenteral nutrition
- Where
- 3 sites in Belgium, Canada and 1 more
- Volunteers
- 1,440 people
- Sponsor
- KU Leuven
Pediatric Cancer, Critically Ill
ONCOTIPNET: Multicenter Study on Risk Factors and Outcome in Cancer Pediatric Patients Admitted in Italian PICUs
The study will describe characteristics of pediatric cancer patients admitted to Italian PICUs and will analyze risk factors of PICU admission, neurological outcome, and mortality.
- Trial name
- ONCOTIPNET (NCT04581655)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera di Padova
Sepsis, Critical Illness
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis…
- Trial name
- NCT01889264
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Critical Illness
Family Care Conferences Criteria in the Pediatric Intensive Care Unit
Multidisciplinary experts from two Pediatric Intensive Care Units (PICUs), used an iterative modified Delphi process to develop and refine criteria for determining PICU patients for whom a family care conference would be…
- Trial name
- NCT04298281
- Where
- 2 sites in United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Critical Illness
Effectiveness and Safety of an Early Mobilization Protocol in a Pediatric Intensive Care Unit
This study evaluates the safety and effectiveness of an early rehabilitation program in a pediatric intensive care unit (PICU). Half of the participants will receive intensive and frequent an early mobilization program and others…
- Trial name
- NCT04524065
- Testing
- Early rehabilitation protocol for children hospitalized in the PICU
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Samsung Medical Center
Clinical Implementation, Standardized Tube Feeding Care
Clinical Implementation of the Group Standard for Enteral Feeding Care in Critically Ill Children
This study aims to evaluate the feasibility and effectiveness of the " Standard for Enteral Feeding Care in Critically Ill Pediatric Patients " (T/CNAS 45-2024) in a multicenter setting.
- Conditions
- Clinical Implementation, Standardized Tube Feeding Care, Enteral Nutrition
- Trial name
- NCT07441746
- Testing
- Evidence-based tube feeding care, Routine Enteral Feeding Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Electronic Application of a Severe Sepsis Screening Tool and Management Bundle
Thousands of children die from Sepsis following routine infections. Many of these deaths can be prevented with earlier recognition and focused management.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- eASSIST-M (NCT01724463)
- Testing
- Severe Sepsis Management Bundle
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- University of Tennessee
Seizure
OPALS Pediatric Study
The OPALS Pediatric Study will examine the incremental impact of introducing a prehospital full advanced life support in pediatric patients.
- Trial name
- NCT00298532
- Testing
- Advanced Life Support
- Where
- 10 sites in Canada
- Volunteers
- 9,000 people
- Sponsor
- Ottawa Hospital Research Institute