Clinical trials: Pediatric Traumatic Brain Injury
Traumatic Brain Injury, Computed Tomography
Evaluation of Pediatric Procedural Sedation With Rectal Chloral Hydrate or Intranasal Midazolam
Thousands of children receive sedation for diagnostic and therapeutic interventions annually, and this number is expected to increase. Children are at higher risk for sedation-related complications than adults.
- Conditions
- Traumatic Brain Injury, Computed Tomography, Procedural Sedation
- Trial name
- NCT01402596
- Testing
- Midazolam, Chloral Hydrate
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Traumatic Brain Injury, TBI
Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury (TBI) - methylphenidate treatment
- Conditions
- Traumatic Brain Injury, TBI, ADHD
- Trial name
- NCT01933217
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild, Concussion, Brain
Acute Concussion and Melatonin
In this study, the investigator plans a randomized trial of melatonin versus placebo post acute pediatric concussion. The investigator hypothesizes that patients with acute concussions managed with melatonin will have improved…
- Conditions
- Concussion, Mild, Concussion, Brain, Pediatric ALL
- Trial name
- NCT04731974
- Testing
- Melatonin 3 MG
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Traumatic Brain Injury, Orthopedic Injury
Epigenetic Effects on Traumatic Brain Injury Recovery
Methylation of the brain-derived neurotrophic factor (BDNF) gene is involved in both the biological encoding of childhood adversity and neuroplasticity following traumatic brain injury (TBI).
- Trial name
- EETR (NCT04186429)
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury
Physiologic Mechanisms in Pediatric Traumatic Brain Injury (TBI)
The aims of this study explore the relationships between cerebral vasospasm, apolipoprotein-E (apo-E) genotype, physiologic symptoms, and neurocognitive outcomes that may either intensify or ameliorate secondary injury, for…
- Trial name
- NCT01763892
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Pediatric Traumatic Brain Injury
Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury
The overall purpose of this research study is to investigate the safety of pharmacological therapies that may potentially improve pediatric outcomes after traumatic brain injury.
- Trial name
- Pro-NAC (NCT01322009)
- Testing
- Probenecid and N-acetyl cysteine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Pittsburgh
Pediatric Acute Neurologic Disease, Traumatic and Non-traumatic
RCT: Early Rehabilitation Protocol vs. Usual Care in the Pediatric ICU for Children With Acute Brain Injury
Background. Early rehabilitation programs (ERP) that include physical, occupational, and speech therapies lessens debilitation and promotes return to previous physical and cognitive functioning and have been successfully applied…
- Trial name
- NCT02209935
- Testing
- Early Rehabilitation Protocol, Usual care
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Pittsburgh
Craniocerebral Trauma, Pediatrics
Study Assessing Evaluation of the Interest of Serum S100B Protein Determination in the Management of Pediatric Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) is a very common reason for presentation to pediatric emergency departments. So as not to overlook the risk of complications, which occur at a rate of 0-7%, measures such as cranial computed…
- Trial name
- PROS100B (NCT02819778)
- Testing
- usual care, S100B
- Where
- 11 sites in France
- Volunteers
- 2,209 people
- Sponsor
- University Hospital, Clermont-Ferrand
Traumatic Brain Injury
Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury
Pediatric severe traumatic brain injury (TBI) is the leading cause of death and disability in children ages 1-14 years old. There are no effective therapies to treat secondary brain injury and the post-injury response of CNS…
- Trial name
- NCT01851083
- Testing
- autologous bone marrow mononuclear cells
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Injury
Vasospasm in Pediatric Traumatic Brain Injury
The purpose of this study is to assess for vasospasm using Transcranial Doppler (TCD) and brain injury biomarkers, and evaluate neurocognitive outcome data in pediatric traumatic brain injury (TBI) patients who have experienced a…
- Trial name
- PTBI (NCT01461902)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Concussion, Mild Traumatic Brain Injury
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
In recent years, media attention has focused on the long-term sequelae of repeated concussive episodes in professional athletes.
- Trial name
- NCT01903525
- Testing
- Docosahexaenoic acid (DHA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Emotions, Memory Deficits
Brain Response to Treatment for Pediatric PTSD
This study will examine how brain activation changes as a result of behavioral treatment for posttraumatic stress disorder (PTSD) in adolescents.
- Conditions
- Emotions, Memory Deficits, Post-traumatic Syndrome
- Trial name
- NCT01806701
- Testing
- Trauma-focused cognitive behavioral therapy
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Stanford University
Brain Injury, Traumatic Brain Injury
Creatine Supplementation in Pediatric Brain Injury
A study examining the effects of creatine supplementation to improve recovery after brain injury in children and teenagers.
- Conditions
- Brain Injury, Traumatic Brain Injury, Stroke
- Trial name
- BOOST (NCT07756060)
- Testing
- Creatine monohydrate, Microcrystalline Cellulose
- Volunteers
- 46 people
- Sponsor
- Spaulding Rehabilitation Hospital
Concussion, Brain, Concussion, Mild
The Role of Cerebral Oximetry in Pediatric Concussion Assessment
The purpose of this study is to determine whether there is a difference in cerebral oxygenation as measured by near-infrared spectroscopy (NIRS) in children with concussion and healthy controls.
- Conditions
- Concussion, Brain, Concussion, Mild, Traumatic Brain Injury
- Trial name
- NCT02036333
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Concussion, Brain, Concussion, Mild
Mobile Subthreshold Exercise Program for Concussion--R01
Approximately 1.9 million youth sustain a concussion each year, and up to 30% experience persistent post-concussive symptoms (PPCS) such as headache, dizziness, and difficulty focusing that continue for weeks or months.
- Conditions
- Concussion, Brain, Concussion, Mild, Brain Injuries, Traumatic, Persistent Post Traumatic Headache
- Trial name
- MSTEP-R01 (NCT04688255)
- Testing
- MSTEP, Stretching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Severe Traumatic Brain Injury
Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics
Narrative: Worldwide, traumatic brain injury (TBI) is a leading cause of death and disability among children and adolescents. The Investigators aim to test whether pediatric TBI treatment guided by invasive intracranial pressure…
- Trial name
- BELA TRIPP (NCT05566431)
- Testing
- ICP, CREVICE
- Where
- 11 sites in United States, Colombia and 4 more
- Volunteers
- 428 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Pediatric
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
Traumatic brain injury in children can cause serious and long-lasting neuro-disability. However, there is still limited evidence about the best ways to treat children with severe brain injury in intensive care.
- Conditions
- Traumatic Brain Injury, Pediatric, Cerebral Perfusion Pressure, Cerebral Autoregulation
- Trial name
- ARTSHIP (NCT07834476)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Traumatic Brain Injury, Brain Concussion
Ondansetron for Pediatric Mild Traumatic Brain Injury
Background: Most patients suffering from mild Traumatic Brain Injury (mTBI) present persistent symptoms at one week post injury. A systematic review showed a paucity of studies for short term outcomes following mTBI.
- Trial name
- NCT01815125
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- St. Justine's Hospital
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
BIOmarkers of TRAumatic Brain Injury Spain (BIOTRABIS)
Traumatic brain injury (TBI) is defined as a structural alteration of brain function caused by external causes, where mild traumatic brain injury (mTBI) represents approximately 80% of all TBI, and although its prognosis is…
- Trial name
- BIOTRABIS (NCT04641767)
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Virgen Macarena
Mild Traumatic Brain Injury, Concussion
Effect of Early Rest on Recovery From Pediatric Concussion
The purpose of this study is to find out if strict rest for 5 days helps children get better after concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post-concussive Syndrome
- Trial name
- NCT01101724
- Testing
- Mandated Rest, Intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical College of Wisconsin