Clinical trials: Penicillin Sensitivity
Drug Hypersensitivity, Penicillin Allergy
Drug Challenges Without Prior Skin Testing
The investigators are conducting a prospective study to determine the safety and outcomes of placebo-controlled graded drug challenges without prior skin testing in patients with a low-risk history of antibiotic hypersensitivity…
- Conditions
- Drug Hypersensitivity, Penicillin Allergy, Antibiotic Allergy
- Trial name
- NCT03158831
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Penicillin Allergy
Penicillin Allergy in Shfayim Clinic
revising penicillin allergy in the medical records, by taking full medical history and giving a challange test, in order to imrove the medical records and treatment possibilities.
- Trial name
- NCT03499457
- Testing
- Amoxicillin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Bronchitis, Acute, Community-acquired Pneumonia
Multimodal Stewardship Programme to Improve Antibiotic Prescribing for Children With Lower Respiratory Tract Infections
Children with lower respiratory tract infection (LRTI) are still often prescribed antibiotics in ways that depart from national guidelines.
- Conditions
- Bronchitis, Acute, Community-acquired Pneumonia, Respiratory Tract Infections
- Trial name
- PRACTICE-LRTI (NCT07893834)
- Testing
- PRACTICE-LRTI multimodal antimicrobial stewardship programme
- Where
- Finland
- Volunteers
- 50,000 people
- Sponsor
- Tampere University
Penicillin Allergy, Penicillin Reaction
Penicillin De-labeling in the Pediatric Primary Care Setting
While reported adverse reactions to penicillins are common, most patients with a penicillin allergy label can safely tolerate penicillins, and elective evaluation for penicillin allergy has been recommended.
- Trial name
- NCT05010304
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Texas Southwestern Medical Center
Penicillin Allergy
The Frequency of Positive Challenge Test to Penicillin in Children Suspected to Have Allergy to Penicillin
The incidence of reactions during penicillin challenge tests among children with suspected penicillin allergy
- Trial name
- NCT02702349
- Testing
- penicillin test
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Penicillin Allergy
Penicillin Allergy Delabeling Among Surgical Patients
Penicillin allergy testing among surgical patients
- Trial name
- PenDel (NCT05956080)
- Testing
- Allergy testing
- Volunteers
- 600 people
- Sponsor
- University Medicine Greifswald
Penicillin Allergy, Pediatric Emergency Medicine
Oral Challenge in the Pediatric ED
Our primary objective was to demonstrate the feasibility of utilizing a novel penicillin allergy questionnaire in the PED to identify a low-risk group of patients who will complete an oral challenge in the PED to test for an…
- Trial name
- OPEN (NCT03404804)
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical College of Wisconsin
Beta Lactam Adverse Reaction
B-lactam Databank Algorithm
Background: Antibiotic allergy constitutes a major health problem with serious medical and financial consequences when under- but also overdiagnosed. About one and a half million Belgians report having an allergy to penicillin.
- Trial name
- NCT06243380
- Where
- Belgium
- Volunteers
- 921 people
- Sponsor
- University Hospital, Antwerp
Penicillin Allergy, In-hospital Process Optimization
A Digital Stewardship Strategy for Patients With Reported Penicillin Allergy
The goal of this clinical study is to evaluate whether a digital decision support tool integrated into the electronic medical record improves antibiotic prescribing in hospitalized patients with a reported allergy to penicillin.
- Trial name
- Digitalpen (NCT07604597)
- Where
- Spain
- Volunteers
- 182 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Bacterial Resistance, Methicillin-Sensitive Staphylococcus Aureus Infection
Antistaphylococcal Betalactam and Emergence of Resistance
Antistaphylococcal penicillins are recommanded as first-line agent in methicillin-suceptible Staphylococcus aureus bacteraemia. Several studies in progress are investigating the efficacy and safety of cefazolin compared with…
- Trial name
- CePasR (NCT05939479)
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Central Hospital, Nancy, France
Penicillin Allergy
Oral Penicillin Challenge and Allergy De-labeling in Children
The primary purpose of this study is to investigate the portion of penicillin allergy labels that are not true allergies using oral amoxicillin challenges among pediatric patients.
- Trial name
- NCT05563610
- Testing
- Amoxicillin 500mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Phoenix Children's Hospital
Penicillin Allergy
Penicillin Allergy Delabeling Project
A investigational study to establish: 1. A validated cllinical pathway for delabeling declared Penicillin allergiy outside allergologic departments. 2.
- Trial name
- PenProv (NCT05090527)
- Testing
- Risk stratification
- Where
- 2 sites in Norway
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Penicillin Allergy
Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic.
- Trial name
- NCT04441021
- Testing
- Penicillin Allergy Risk Stratification and Evaluation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Penicillin Allergy
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams
This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.
- Trial name
- NCT00789217
- Testing
- Immediate skin test
- Where
- Thailand
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Penicillin Allergy
Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin
The purpose of this study is to examine whether oral challenge with penicillin for patients with a known history of non-life threatening allergic reaction to penicillin is well-tolerated irrespective of skin-testing results
- Trial name
- NCT00363688
- Testing
- Penicillin test and challenge
- Where
- Israel
- Sponsor
- Meir Medical Center
Penicillin Allergy, Aminopenicillin Allergy
The Diagnosis of Beta-lactam Hypersensitivity in Thailand
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand.
- Conditions
- Penicillin Allergy, Aminopenicillin Allergy, Beta Lactam Adverse Reaction
- Trial name
- NCT01667055
- Where
- Thailand
- Volunteers
- 500 people
- Sponsor
- Chulalongkorn University
Antibiotic Allergy
Penicillin Allergy Risk-Stratification and Delabeling of Low-Risk Patients
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic, however, recent studies have demonstrated that the majority of symptoms reported as an…
- Trial name
- NCT05561777
- Testing
- Physician-targeted CDS tool for PCN allergy delabeling
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Penicillin, Drug Allergy
Inpatient Penicillin Delabeling for Low-Risk Patients
This study seeks to enroll patients admitted to a children's hospital with identified penicillin allergy. A screening checklist is performed to identify patients with very low or low risk histories of penicillin allergy to offer…
- Trial name
- NCT06414694
- Testing
- Direct Oral Challenge
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Tennessee
Penicillin Allergy
Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family.
- Trial name
- NCT02036840
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Joseph D. Tobias