Clinical trials: Perforation
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Bowel Obstruction, Ovarian Cancer
Does Cediranib Prevent Bowel Perforation in Platinum-resistant Ovarian Cancer
Ovarian cancer can often grow and cause obstructions in the bowel. These obstructions usually cannot be removed with surgery and can be fatal.
- Conditions
- Bowel Obstruction, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- CEBOC (NCT07648745)
- Testing
- Cediranib
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Prof Gordon Jayson
Tympanic Membrane Perforation
Eustachian Tube Function and Myringoplasty/Tympanoplasty
This study will determine whether the likely success of closing a hole in the eardrum can be predicted by testing Eustachian tube function.
- Trial name
- NCT01766856
- Testing
- Eustachian tube function testing
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Perforated Appendicitis
Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
To compare the effect of a single-agent home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis
- Trial name
- NCT02724410
- Testing
- home intravenous ertapenem, home oral amoxicillin-clavulanate, peripheral inserted central Catheter
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated…
- Trial name
- PA protocol (NCT04039750)
- Testing
- antibiotic rinse with suction, suction only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Prisma Health-Upstate
Necrotizing Enterocolitis
Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis
This is a retrospective study led by The Sixth Affiliated Hospital, Sun Yat-sen University, focusing on newborns diagnosed with necrotizing enterocolitis (NEC)-a serious gastrointestinal disease that threatens newborns'…
- Trial name
- ACLPNEC (NCT07207915)
- Testing
- Observational retrospective cohort study
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pectus Excavatum, Pain, Postoperative
Sub-Paraspinal Block in Nuss Patients. A Pilot Project
The purpose of this pilot study was to evaluate effectiveness of a novel regional anesthesia technique developed at the investigators institution, as part of a quality improvement initiative, to assist with multilevel thoracic…
- Trial name
- NCT02169297
- Testing
- Ultrasound-guided Sub-Paraspinal Block, PCA only
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Macular Holes, Epiretinal Membrane
Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies
The aim of the study is to identify morphological and functional biomarkers of post-operative recovery after vitreoretinal surgery, using decisional support systems (DSS), based on multimodal big-data analysis by means of machine…
- Conditions
- Macular Holes, Epiretinal Membrane, Retinal Detachment, Macular Dystrophies
- Trial name
- MICAI (NCT05747144)
- Testing
- Biometry, Retinography (Color) + Autofluorescence (AF), OCT B-scan and OCT angiography (OCTA)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Perforation, Coronary Stent Occlusion
Glasgow Natural History Study Of Covered Coronary Interventions
Covered stents (CS) are a potentially lifesaving treatment for grade III coronary perforation but delivery can be challenging, and the long-term durability and safety including risk of acute stent thrombosis are unknown.
- Conditions
- Coronary Artery Perforation, Coronary Stent Occlusion, Stent Thrombosis
- Trial name
- GNOCCI (NCT03862352)
- Testing
- Covered coronary stent
- Where
- United Kingdom
- Volunteers
- 161 people
- Sponsor
- NHS National Waiting Times Centre Board
Orthodontics
Effect of Micro-osteo-perforations on the Rate of Alignment of Mandibular Anterior Teeth.
Micro osteoperforation is an easy, safe and effective method of accelerating orthodontic tooth movement by 2-3 times.it has been reported to increased the osteoblastic activity and some acceleration of the rate of canine…
- Trial name
- NCT05132764
- Testing
- Microosteoperforations
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Perforated Duodenal Ulcer
Scoring System in Predicting Perforated Duodenal Ulcer Morbidity and Mortality in Bpkihs
Different scoring systems were developed for risk prediction and adjustment of morbidity from perforated duodenal ulcer. However, these scoring systems are not routinely used in perforated duodenal ulcer patient in everyday…
- Trial name
- NCT04994184
- Where
- Nepal
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Esophageal Fistula, Esophageal Perforation
Endoscopic Management of Esophageal Wall Defects
The study aim at comparing outcomes from the implementation of various endoscopic closure techniques including stenting and suturing on the healing and resolution of esophageal wall defects.
- Trial name
- NCT04571541
- Testing
- Stenting
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Tympanic Membrane Perforation, Eardrum Perforation
Biodesign® Otologic Repair Graft
The post-market follow-up clinical trial of the Cook® Biodesign® Otologic Repair Graft will follow patients up to 3 months post-implantation to determine the percent of patients with complete closure of the tympanic membrane.
- Trial name
- NCT04635228
- Testing
- Biodesign Otologic Repair Graft
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 87 people
- Sponsor
- Cook Research Incorporated
Tympanic Membrane Perforation
Hearing Results and Post Surgical Outcomes Using Amniotic Membrane Allograft vs. Fascia for Tympanoplasty
The trial seeks to provide evidence that the Skye ActiveBarrier provides similar surgical and functional outcomes as fascia when used for tympanoplasties while offering benefits including reduced operative time, better patient…
- Trial name
- NCT03028272
- Testing
- Skye Barrier, Fascia
- Sponsor
- University of Missouri-Columbia
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Laparoscopic Surgery, Acute Appendicitis With Rupture
Open to Laparoscopic Reverse Conversion of Perforated Appendicitis
A Prospective Randomized Controlled Trial of Reverse Conversion (Open to Laparoscopic) in management of Acute Perforated Appendicitis
- Conditions
- Laparoscopic Surgery, Acute Appendicitis With Rupture, Sepsis, Abdominal Abscess
- Trial name
- reverse (NCT05283733)
- Testing
- reverse conversion technique
- Where
- Egypt
- Volunteers
- 426 people
- Sponsor
- Zagazig University
Macular Holes
Double Flap Technique for Macular Hole
Double flapping technique to close the macular hole.
- Trial name
- NCT05269563
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- Omer Othman Abdullah