Clinical trials: Perfusion; Complications
Epithelial Ovarian Cancer, Acute Kidney Injury Due to Circulatory Failure
Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy
Ovarian cancer is the most lethal malignancy of the female genital tract. Cytoreductive surgery combined with chemotherapy is the primary treatment for ovarian cancer, and radical tumor resection is an important means to improve…
- Trial name
- NCT05877911
- Testing
- Sodium Sulfate, Hydration, Cisplatin
- Volunteers
- 110 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Kidney Failure, Acute
Fenoldopam in Pediatric Cardiac Surgery
The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction…
- Trial name
- NCT00982527
- Testing
- Fenoldopam
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Advanced Cancers, Sarcoma
Pilot Study of Hyperthermic Peritoneal Perfusion (HIPEC) for Adolescent and Young Adults With Desmoplastic Small Round Cell Tumor
The goal of this clinical research study is to learn if heated intra-abdominal cisplatin can help to control abdominal tumors in patients having surgery to remove the tumors. The safety of this drug will also be studied.
- Trial name
- NCT01277744
- Testing
- Hyperthermic Peritoneal Perfusion (HIPEC), Cisplatin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Transplant; Complications
Kidney Transplant Monitoring Using Near Infra-red Spectroscopy
Kidney transplant thrombosis (loss of blood flow) is responsible for up to 35% transplant failures in children. Detection of kidney transplant thrombosis currently relies on recognition of deterioration in parameters such as…
- Trial name
- NCT02956018
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Fetal Growth Retardation
Sildenafil and Uteroplacental Perfusion
The purpose of this study is to determine whether sildenafil is effective and safe in the treatment of fetal growth restriction.
- Trial name
- NCT01107782
- Testing
- sildenafil
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Peritoneal Neoplasms, Retroperitoneal Neoplasms
Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer
There has been no successful treatment of diffuse peritoneal metastasis or carcinomatosis, in childhood tumors. Once this advanced stage of disease is evident, survival is measured in weeks.
- Conditions
- Peritoneal Neoplasms, Retroperitoneal Neoplasms, Gastrointestinal Neoplasms, Adenocarcinoma
- Trial name
- NCT00436657
- Testing
- CHPP of Cisplatin, Abdominal Surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Premature, Necrotizing Enterocolitis
Intestinal Perfusion After Feeding in Preterm and Term Infants
This is a pilot exploratory observational prospective cohort phase I study. In this study, we will gather preliminary data to evaluate (i) the magnitude of changes in blood flow in the bowel before and after feeding and (ii) the…
- Trial name
- NCT06319326
- Testing
- Evaluation of intestinal perfusion with color Doppler abdominal ultrasound before and after feeding.
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Aortic Dissection, Perfusion; Complications
Intravascular Ultrasound for the Evaluation of Malperfusion Syndrome in the Setting of Acute Aortic Dissection
Aortic dissection is a life-threatening condition caused by a tear in the internal layer of major artery wall (aorta) that carries blood to all body organs, resulting in separation of the aortic wall layers (dissection).
- Trial name
- NCT04907071
- Testing
- Intravascular ultrasound 0.035 PV IVUS catheter (Volcano Therapeutics, Rancho Cordova, CA)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre
Cervical Cancer, Cervical Intraepithelial Neoplasm
The Role of Blood Perfusion in Cervical Cancer, Cervical Intraepithelial Neoplasm and Ovarian Cancer Patients
This study will elucidate the role of 3D transvaginal ultrasound in assessing (1) cervical vascularity and blood flow in patients with cervical cancer and cervical intraepithelial neoplasm, and (2) tumor vascularity and blood…
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasm, Ovarian Cancer
- Trial name
- NCT07385976
- Testing
- Doppler ultrasound
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Liver Failure, Kidney Failure
NIRS as a Continuous Noninvasive Monitoring System of Liver/Kidney Graft Perfusion
The aim of the investigators work is to describe the agreement between NIRS and ecodoppler, as monitoring systems of liver and kidney graft's perfusion in the immediate postoperative period in pediatric patients.
- Trial name
- NIRS (NCT02343016)
- Testing
- Near-InfraRed Spectroscopy (NIRS)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Mariella Enoc
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Ovarian Neoplasms
MRI in Ovarian Tumors
Role of multi paramrtric MRI and MRI perfusion in indetermint ovarian lesions by using ORADS MRI
- Trial name
- NCT05769205
- Testing
- MRI
- Volunteers
- 25 people
- Sponsor
- Assiut University
Aortic Arch Hypoplasia or Atresia
Modified Perfusion for Neonatal Aortic Arch Reconstruction
Even though the lower part of the body does receive some blood supply during Cardiopulmonary Bypass(CPB) surgery, it may not be enough.
- Trial name
- NCT00490256
- Testing
- Modified Selective Cerebral Perfusion
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Postoperative Pain, Caudal Anesthesia
Effect of Intravenous Versus Caudal Dexmedetomidine on Perfusion Index and Hemodynamic Responses in Children Undergoing Infraumbilical Surgery
Caudal anesthesia is widely used to provide pain relief for children undergoing surgery below the navel (infraumbilical surgery).
- Conditions
- Postoperative Pain, Caudal Anesthesia, Peripheral Perfusion, Pediatric Surgery
- Trial name
- NCT07852039
- Testing
- Caudal Dexmedetomidine, Intravenous Dexmedetomidine
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Pain, Adenotonsillectomy
Perfusion Index for Postoperative Pain Assessment in Pediatric Adenotonsillectomy
This randomized controlled trial aims to evaluate the usefulness of the perfusion index (PI) as an objective measure of postoperative pain in children aged 1-12 years undergoing adenotonsillectomy.
- Conditions
- Postoperative Pain, Adenotonsillectomy, Pain, Pediatric
- Trial name
- NCT07915804
- Testing
- Bilateral Intraoral Glossopharyngeal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Intracranial Hemorrhage, Intraventricular Hemorrhage
Observational Study in Preterm Infants With Intracranial Hemorrhage
Intracranial Hemorrhage (ICH) is an important morbidity affecting premature infants and can have considerable effects on neurodevelopmental outcome.
- Conditions
- Intracranial Hemorrhage, Intraventricular Hemorrhage, Cerebral Hypoxia
- Trial name
- NCT01620203
- Testing
- No intervention/treatment is given
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Nelson Claure
Intraventricular Hemorrhage, Periventricular Leukomalacia
Prediction of Brain Injury in Premature Infants
Extremely low birth weight (ELBW), birth weight less than or equal to 1000 g, infants are at high risk for developing brain injury in the first week of life.
- Conditions
- Intraventricular Hemorrhage, Periventricular Leukomalacia, Brain Injury, Extreme Prematurity
- Trial name
- NCT02814383
- Testing
- Brain Monitoring Platform
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Baylor College of Medicine
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
Database of Monochorionic Pregnancies
The purpose of this study is to collect and analyze data regarding natural history, indications for fetal interventions, and maternal and fetal/neonatal outcomes associated with complicated monochorionic twin pregnancy.
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Twin; Complicating Pregnancy, Twin to Twin Transfusion Syndrome
- Trial name
- NCT05543499
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Miami
Awareness, Anesthesia
Validity of Perfusion Index to Evaluate the Level of General Anaesthesia in Children.
The aim of this study is to evaluate the validity of perfusion index to determine the level of anesthesia in comparison with auditory evoked potential in children undergoing tonsillectomy.
- Trial name
- PI/AAI (NCT03412214)
- Testing
- Perfusion index detected by pulse oximeter, AAI
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Assiut University
Premature Birth, Extremely Low Birth Weight
DCS Study in Extremely Premature Newborns
The researchers are attempting to improve the cerebral monitoring of extremely low gestational age (ELGA) infants, such that in the future, real-time monitoring will be possible, to aid clinicians in management of these infants.
- Conditions
- Premature Birth, Extremely Low Birth Weight, Infant, Small for Gestational Age, Intracerebral Hemorrhage
- Trial name
- NCT04367181
- Testing
- Diffuse Correlation Spectroscopy (DCS), Amplitude Integrated Electroencephalography (aEEG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Maria Angela Franceschini