Clinical trials: Periapical Lesion
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pulp Revascularization
Outcome of Pulp Revascularization of Necrotic Mature Permanent Teeth Using Platelet-rich Fibrin
Regenerative endodontic procedures are intended to replace damaged tooth structures, including dentine and root structures, in addition to cells of the pulp-dentine complex.
- Trial name
- NCT06347640
- Testing
- induced bleeding, plasma rich fibrin
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Periradicular Disease
Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy
The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.
- Trial name
- NCT02555488
- Testing
- diode laser, Methylene blue
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Periapical Periodontitis, Periradicular Lesion
Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide.
The goal of this clinical trial is to evaluate the surgical accuracy and healing outcomes of endodontic surgery performed with the assistance of a 3D-printed static surgical guide in patients requiring apicoectomy.
- Conditions
- Periapical Periodontitis, Periradicular Lesion, Endodontic Treatment Failure, Postoperative Wound Healing
- Trial name
- NCT07734987
- Testing
- 3D-Printed Static Surgical Guide and Trephine Bur, Ultrasonic Retrograde Preparation and Bioceramic Retrograde Obturation
- Where
- Vietnam
- Volunteers
- 11 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periapical Lesions
The Accuracy of Computer Aided Detection of Periapical Radiolucencies on Cone -Beam Computed Tomography Images Using Artificial Intelligence
A diagnostic accuracy study to assess the accuracy of a newly developed deep learning model in the automatic detection of periapical radiolucent lesions of upper and lower jaws by comparing it with experienced radiologists'…
- Trial name
- NCT05538104
- Volunteers
- 50 people
- Sponsor
- Cairo University
Periapical Lesion
Guided Tissue Regeneration in Healing of Through and Through Periapical Lesion
Aim of this study is to evaluate the effect of i-PRF in the healing of through and through periapical lesion after periradicular surgery
- Trial name
- NCT04391725
- Testing
- Periapical surgery with guided tissue regeneration, Periapical surgery without anyguided tissue regeneration
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Lesion
The Effect of Injectable Platelet Rich Fibrin on Apical Lesion Healing
In recent years, the use of autologously obtained blood products that stimulate cell proliferation, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), has become increasingly widespread.
- Trial name
- NCT07876427
- Testing
- i-PRF, root canal treatment and intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hande Has Elçi
Odontogenic Cysts, Keratocysts of the Jaw
Decompression of Odontogenic Cysts
The aim of this case-control study is to evaluate the effects of decompression of cystic jaw lesions by means of comparing pre- and post-decompression histologic findings.
- Conditions
- Odontogenic Cysts, Keratocysts of the Jaw, Cysts Dental, Pathology
- Trial name
- NCT06536907
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Mandibular Premolars and Canines With Asymptomatic Apical Periodontitis
The Effect of Different Irrigation Methods Used During Endodontic Treatment on Postoperative Pain in Teeth With Periapical Lesions
The aim of this study is to evaluate the effect of different irrigation activation methods used during endodontic treatment on postoperative pain in teeth with periapical lesions, allowing us to clinically determine which…
- Trial name
- NCT07410832
- Testing
- Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Carious Teeth
Evaluation of Survival of Mature Second Premolar Treated With Regenerative Techniques
This study aims to compare the ability of different regenerative protocols in the treatment of mature necrotic
- Trial name
- NCT02915419
- Testing
- PRP, PRF
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Reversible Pulpitis
Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial
This study aims to investigate the tooth nerve response to a recently introduced therapeutic filling material (calcium silicate cement) called Biodentine and to assess the quality of the overlying filling compared to another…
- Trial name
- NCT02201641
- Testing
- Cone Beam computed tomography (Morita Accuitomo), Periapical radiographs, calcium silicate cement (Biodentine™)
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- King's College London
Periapical Diseases, Endodontic Disease
Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication
The recovery of periapical defects linked to periodontal communication frequently yields less satisfactory results. Numerous studies and case reports have highlighted the notable success achieved through the application of guided…
- Trial name
- NCT06643663
- Testing
- Endodontic Micro-Surgery
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis
Effect of Coronal Extent of Obturation on Endo-perio Lesions
Increased incidence of apical periodontitis was reported where root filling was found coronal to the marginal bone due to communication between pulp and periodontal space.
- Trial name
- NCT03171376
- Testing
- Root canal treatment and coronal restoration
- Volunteers
- 60 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Periapical Diseases
Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth
Traumatic tooth injuries are common in children and adolescents, and often result in pulpal necrosis and the development of periapical lesions.
- Trial name
- NCT02625298
- Testing
- ProRoot MTA, MTA+ Cerkamed
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Association of Paediatric and Preventive Dentists of Serbia
Pain, Postoperative, Periapical; Infection
Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in LSTR
The aim of this study is to evaluate and compare the clinical effectiveness of zinc oxide-propolis mixture with triple antibiotic paste in LSTR as root canal filling material in necrotic primary molars.
- Trial name
- NCT06158451
- Testing
- Zinc oxide propolis, Modified triple antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Diseases
Effect of Aloe Vera Gel as an Intra Canal Medicament
This research will overview the effect of aloe vera gel (AVG) as intra canal medicament in patients with asymptomatic periapical lesions.
- Trial name
- NCT06243601
- Testing
- Aloe vera Gel
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Islamabad Medical and Dental College
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University
Apical Periodontitis, Periapical Radiolucency
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and…
- Trial name
- NCT07289971
- Testing
- Allium Sativum as an intracanal medicament
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment
Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Revascularisation of Necrotic Immature Permanent Teeth
The goal of this clinical trial is to evaluate the effectiveness of an advanced platelet-rich fibrin plus (A-PRF+) revascularization procedure to promote healing and root development in necrotic immature permanent single-rooted…
- Conditions
- Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment, Pulp Regeneration, Root Maturation
- Trial name
- A-PRF+ (NCT07092488)
- Testing
- Advanced Platelet-Rich Fibrin Plus (A-PRF+) Revascularization Procedure
- Where
- Croatia
- Volunteers
- 28 people
- Sponsor
- University of Zagreb