Clinical trials: Periodontal Disease : Chronic Periodontitis
Chronic Periodontitis
Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis
Periodontal disease is an immune-inflammatory disease which consists of connective tissue breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an equilibrium maintained between reactive oxygen…
- Trial name
- NCT03533972
- Testing
- Ashwagandha
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Periodontitis, Smoking
Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis
This study comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects.
- Trial name
- NCT03426241
- Testing
- no intervention
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baskent University
Periodontitis, Periodontitis Chronic Generalized Severe
Effect of Non-surgical Treatment of Periodontitis Patients Focusing on Inflammatory Mediators in Gingival Crevicular Fluid
This study investigates inflammatory biomarkers in gingival crevicular fluid (GCF) from smokers and non-smokers with severe periodontitis, before and during non-surgical periodontal therapy (NSPT).
- Trial name
- NONSURG (NCT07503041)
- Testing
- Collecting fluid for biomarker analyses, Hygiene instruction, tooth cleaning, plaque removal
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Generalized Aggressive Periodontitis, Chronic Periodontitis
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Generalized aggressive Periodontitis (GAgP) and chronic periodontitis (CP) are inflammatory diseases. Little is known about molecular changes and signaling cascade of host response.
- Trial name
- NCT04026828
- Testing
- Periodontitis Group
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Periodontitis
Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel
assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planning (SRP) in chronic moderate to severe periodontitis patients…
- Trial name
- NCT03311906
- Testing
- 0.8% Hyaluronic Acid, Scaling and Root Planing
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Chronic Periodontitis
Efficacy of Subgingivally Delivered Doxycycline Plus Ketoprofen Gel as an Adjunct to Non-surgical Periodontal Treatment
Objectives: The aim of the present clinical study was to evaluate the efficacy of doxycyline 3% plus ketoprofen 2.5% as an adjunct to scaling and root planing in the treatment of chronic periodontitis(early-modearte).
- Trial name
- NCT02538224
- Testing
- 2.5%ketoprofen gel + 3 % doxycycline, :2.5%ketoprofen gel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Thalassemia Major, Chronic Periodontitis
Periodontal Therapy in Thalassemia Major Patients
The study aims to evaluate the effect of local non surgical periodontal therapy on the systemic pro-inflammatory markers in the β-thalassemia (TM-β) patients with chronic periodontitis and systemically healthy demographically…
- Trial name
- NCT03311243
- Testing
- Non surgical periodontal therapy, Chemical plaque control
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- King Saud University
Chronic Kidney Diseases, Caries,Dental
Assessment of The Oral Health Status of Children With Chronic Kidney Disease
The aim of this study is to compare the oral health findings, salivary parameters and disease-related quality of life of children with different stages of Chronic Kidney Disease(CKD), those undergoing dialysis and…
- Conditions
- Chronic Kidney Diseases, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06578832
- Testing
- physical and chemical methods, biochemical methods, biochemical tests
- Where
- Turkey (Türkiye)
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Marmara University
Type 2 Diabetes Mellitus, Chronic Periodontitis
The Effect Of Glycemic Control On Malondialdehyde, Glutathione Peroxidase, Glutathione And Paraoxonase
The aim of this study was to investigate the impact of glycemic control on clinical periodontal status, levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) and paraoxonase (PON) activity in…
- Trial name
- NCT01467674
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Polycystic Ovary Syndrome, Periodontitis
Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis
The Purpose of this study is to assess the correlation between the inflammatory periodontal status and the medical treatment status in Polycystic Ovary Syndrome(PCOS) women with systemic inflammation and to evaluate the effect of…
- Conditions
- Polycystic Ovary Syndrome, Periodontitis, Insulin Resistance
- Trial name
- NCT02633462
- Testing
- scaling and root planing , Myo-inositol, Myo-inositol
- Volunteers
- 56 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Pulp Necroses, Apical Periodontitis
Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis
The purpose of the study is to evaluate the effect of Mesenchymal Stromal Cell (MSC) implantation on pulp and periapical regeneration of immature teeth with pulp necrosis and chronic apical periodontitis.
- Trial name
- MSC (NCT04545307)
- Testing
- Allogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis
- Where
- Venezuela
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela
Periodontitis
L-PRF Plus Non Surgical Periodontal Treatment
Abstract: Background: Leucocyte and Platelet-Rich Fibrin (L-PRF) has shown to promote regenerative processes, even reporting antibacterial effect.
- Trial name
- NCT04520438
- Testing
- Leukocyte and platelet rich fibrin, Non-Surgical Periodontal treatment
- Where
- Chile
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Periodontitis, Adult
Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects
The aim: Clinical and Radiographic Evaluation for intra-osseous defects in stage III periodontitis using NIPSA versus M-MIST Steps in short Pre-surgical therapy Before surgical intervention, each patient will be given careful…
- Trial name
- NCT04149834
- Testing
- Group A (Test): Patients will receive NIPSA, Group B (Control): Patients will receive M-MIST
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Adult
Full Mouth Ultrasonic Debridement Carried Out Either by Piezoelectric or Magnetostrictive Device
Treatment of periodontitis requires removal of dental biofilm both through professional mechanical plaque removal and domiciliar oral hygiene procedures.
- Trial name
- NCT05279950
- Testing
- Full-mouth ultrasonic debridement with piezoelectric device (EMS, mini piezon), Full-mouth ultrasonic debridement with magnetostrictive device (Cavitron Select, Dentsply)
- Where
- Italy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Siena
Chronic Periodontitis
IgY Efficacy on Periodontitis Patients
Patients visiting National Hospital of Odonto-Stomatology for treating periodontitis used a food supplement (lozenge) containing chicken egg antibody (IgY) against Porphyromonas gingivalis gingipains as an adjunct to conventional…
- Trial name
- NCT02705885
- Testing
- lozenges containing IgY
- Volunteers
- 60 people
- Sponsor
- Immunology Research Institute in Gifu
Periodontitis, Diabetes Mellitus
Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients
This clinical study randomized 380 diabetic chronic periodontitis patients into 4 groups: scaling and root planning alone (group I), scaling and root planning plus metronidazole gel (group II), scaling and root planning plus…
- Trial name
- NCT06027151
- Testing
- 1ml of 1% metronidazole gel, 1ml of 2% minocycline gel, 1ml of combination of 1% metronidazole gel and 2% minocycline
- Where
- Pakistan
- Volunteers
- 380 people
- Sponsor
- Riphah International University
Chronic Periodontitis
The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis
To evaluate the respective or combinatory efficacy of locally delivered 2% Minocycline (MO) and surface and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating…
- Trial name
- NCT02355977
- Testing
- minocycline, surface and root planning
- Volunteers
- 70 people
- Sponsor
- Zhejiang University
Chronic Periodontitis
The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal…
- Trial name
- NCT03923829
- Testing
- Zinc Sulfate, scaling and root planing
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University