Clinical trials: Peripheral Neuropathic Pain
Cauda Equina Syndrome, Functional Neurological Disorder
BLB Study Back or Leg Pain and Bladder Symptoms Study
The research focuses on Cauda Equina Syndrome (CES) which describes damage to the nerves in the lower back which supply bladder, bowels, sexual function and the legs usually from slipped discs in the spine.
- Trial name
- BLB (NCT03325374)
- Testing
- Questionnaires and examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Cervical Radiculopathy, Cervical Myelomalacia
Cervical Spinal Cord Signal Abnormalities in Patients With Cervical Radicular Pain
This prospective observational study aims to determine the prevalence of cervical spinal cord signal abnormalities, including myelomalacia, among adult patients presenting to a tertiary pain clinic with cervical radicular pain.
- Trial name
- CSCS (NCT07823426)
- Testing
- Clinical and Cervical MRI Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara City Hospital Bilkent
Pain, Irritability
Implementation of the Pain and Irritability of Unknown Origin (PIUO) Pathway in Community Pediatric Practices
The Pain and Irritability of Unknown Origin (PIUO) Pathway is a clinical pathway that was developed to evaluate and manage unexplained pain and irritability for children with severe neurological impairments (SNI) who cannot…
- Conditions
- Pain, Irritability, Neuropathic Pain
- Trial name
- NCT06869928
- Testing
- PIUO Pathway
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Pain
Blood Sample Donations to Study the Role of Genes in Pain
This study attempts to identify genes that may increase or decrease the likelihood of sciatic pain (shooting pain down the leg) persisting 1 year after treatment of a herniated spinal disc.
- Trial name
- NCT00341367
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Healthy, Hyperalgesia
Positron Emission Tomography to Measure Pain and Pain Control
This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli.
- Conditions
- Healthy, Hyperalgesia, Pain, Peripheral Nervous System Disease
- Trial name
- NCT00001307
- Testing
- Oxygen-15 Water, Capsaicin
- Where
- United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Acute Lymphoblastic Leukemia, Neuropathy
Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL)
Neuropathic pain / peripheral neuropathy (NP/PN) is a known painful complication of vincristine (VCR) therapy; evidence supporting the best treatment plan for pediatric patients is limited.
- Conditions
- Acute Lymphoblastic Leukemia, Neuropathy, Neuropathic Pain
- Trial name
- TINALL (NCT01506453)
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- St. Jude Children's Research Hospital
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Neuralgia
Treatment of Upper Limb Chronic Neuropathic Pain by Electrical Stimulation of the Brachial Plexus Nerve Roots
Moderate to severe neuropathic pain has a prevalence of 5% in the French population, involving the upper limb (UL) in 47%. Invasive neuromodulation, mainly spinal cord stimulation (SCS) is recommended as a third line treatment in…
- Trial name
- SIMPLEX (NCT05817786)
- Testing
- electrical stimulation of the brachial plexus nerve roots
- Where
- 3 sites in France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Facial Pain, Comorbidity
Somatosensory Investigation of Orofacial Pain Patients
Orofacial pain, specially neuropathic orofacial pain, is a challenge of diagnosis and treatment in orofacial pain. It is associated with sensory abnormalities.With increasing life expectancy of the population is more and more…
- Conditions
- Facial Pain, Comorbidity, Neuralgia
- Trial name
- QST (NCT02910336)
- Testing
- Quantitative Sensory Testing
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Carpal Tunnel Syndrome (CTS), Kinesio Taping
Effectiveness of Kinesiotaping and Peloidotherapy in Carpal Tunnel Syndrome
Patients diagnosed with mild and moderate idiopathic CTS will be randomly divided into three groups. Patients who received 15 sessions of peloid therapy along with a home exercise program will constitute the first group.
- Conditions
- Carpal Tunnel Syndrome (CTS), Kinesio Taping, Exercise, Pain Management
- Trial name
- NCT06977321
- Testing
- Kinesiotaping, Peloidotherapy, Home exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Chronic Pain, Complex Regional Pain Syndromes
Dance-therapy and Chronic Pain
Pain, when it becomes chronic, can be a threat to patients and it is very common to observe a fear of pain and a fear of movement (kinesiophobia).
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Tension-Type Headache
- Trial name
- ALGODANCE (NCT05689944)
- Testing
- Dance-therapy, Art-therapy, Yoga
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Migraine in Children, Pain, Neuropathic
Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients
Single-center, open-label, pre-post treatment pilot study to evaluate the safety and effectiveness of sphenopalatine ganglia blocks for the treatment of chronic migraine in the pediatric population.
- Trial name
- NCT04466826
- Testing
- Headache Journal, Sphenopalatine Block, Tx360
- Where
- United States
- Sponsor
- Washington University School of Medicine
Neurofibromatosis Type 1
A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)
Background: Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumors to grow along the nerves in the skin, brain, and other parts of the body.
- Trial name
- NCT06507748
- Testing
- AlgometRx Nociometer(R)
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Mitochondrial Diseases, Developmental Delay Disorder
Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders
Background: Small-Fiber-Neuropathy describes the degeneration of mildly or unmyelinated nerve fibers and causes neuropathic pain and autonomic dysfunction.
- Conditions
- Mitochondrial Diseases, Developmental Delay Disorder, Small Fiber Neuropathy, Cerebral Palsy
- Trial name
- SFN_children (NCT05645874)
- Testing
- Skin biopsy
- Where
- Germany
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cerebral Palsy, Excessive Crying
Excessive Crying in Children With Cerebral Palsy and Communication Deficits
Management of excessive crying in children with cerebral palsy and communication deficits [ECCCPCD] was guided by the associated clinical findings and investigations.
- Conditions
- Cerebral Palsy, Excessive Crying, Pain
- Trial name
- ECCCPCD (NCT04523935)
- Testing
- Baclofen, Diazepam, Clonazepam, Trihexyphenidyl, Tetrabenazine, Gabapentin, Topiramate, Lamotrigine, Amitriptyline.
- Volunteers
- 131 people
- Sponsor
- Sathbhavana Brain Clinic
Sciatica
Energy Specific Far Infrared Radiation Treatment for Sciatica
A preliminary study to determine the use of far infrared radiation for the treatment of back pain
- Trial name
- NCT00573807
- Testing
- Far Infrared Radiation (5μm to 20μm wavelength)
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- GAAD Medical Research Institute Inc.
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Pain, Neuropathic Pain
Efficacy of Gabapentin in Treating Pain in Children With SNI (Gabapentin Trial)
Children born with severe brain-based developmental disabilities frequently experience persistent unexplained periods of pain and irritability, often compounded by a limited capacity to communicate their distress.
- Conditions
- Pain, Neuropathic Pain, Irritability
- Trial name
- NCT04619862
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
HIV Infections, Peripheral Nervous System Disease
The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients
To evaluate the separate and combined efficacy of a standardized acupuncture regimen and amitriptyline on the relief of pain due to peripheral neuropathy and on the quality of life of HIV-infected patients.
- Trial name
- NCT00000817
- Testing
- Amitriptyline hydrochloride, Point acupuncture
- Where
- 11 sites in United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cancer, Neuropathy
Nutritional Supplement for Treating Chemotherapy Induced Neuropathy
Administration of a nutritional supplement containing palmitoyethanolamide, alpha lipoic acid, vitamin B12, vitamin B6 , vitamin B1, nicotinamide, magnesium, zinc, vitamin E, and superoxide of dismutase in individuals receiving…
- Conditions
- Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- NCT07022938
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 71 people
- Sponsor
- Aristotle University Of Thessaloniki