Clinical trials: Persistent
Chronic Diarrhea, Persistent Vomitting
Pediatric GI Endoscopy at Assiut University
1. To evaluate the diagnostic role, and outcomes of upper and lower gastrointestinal (GI) endoscopy in identifying gastrointestinal disorders among infants and pediatric patients attending Assiut University Children Hospital. 2.
- Conditions
- Chronic Diarrhea, Persistent Vomitting, Gastrointestinal Bleeding, Dysphagia
- Trial name
- NCT07239934
- Testing
- Gastrointestinal Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Persistent Pulmonary Hypertension of Newborn
Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness
This observational study will seek to describe the uses and safety and efficacy outcomes of treprostinil in clinical practice in patients with persistent pulmonary hypertension (PPHN).
- Trial name
- NEPHY (NCT06499363)
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Ferrer Internacional S.A.
Asthma
SALTO - Symbicort Single Inhaler Therapy Use in Adolescent Adults and Adults With Persistent Asthma
The primary objective is to compare the efficacy of Symbicort Single inhaler Therapy with treatment according to conventional best practice in adolescent and adult patients with persistent asthma.
- Trial name
- NCT00290264
- Testing
- Budesonide/formoterol
- Where
- 209 sites in Belgium, Luxembourg
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Asthma
Study of Fluticasone Propionate Multidose Dry Powder Inhaler Compared With Fluticasone Propionate/Salmeterol Multidose Dry Powder Inhaler
This study is to evaluate the safety and efficacy of fluticasone propionate and fluticasone propionate salmeterol in pediatric participants with a documented history of persistent asthma.
- Trial name
- NCT02980133
- Testing
- Fluticasone Propionate, Fluticasone Propionate/Salmeterol
- Where
- 118 sites in United States, Georgia and 3 more
- Volunteers
- 841 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Asthma in Children
This is a six-month non-interventional prospective study of various controller therapies in children with asthma in outpatient clinical practice.
- Trial name
- NCT01286532
- Where
- 11 sites in Russia
- Volunteers
- 283 people
- Sponsor
- AstraZeneca
PPHN, Hypoxic Respiratory Failure
Predictors of Inhaled Nitric Oxide Responsiveness in Patients With PPHN
To identify biochemical, clinical, or genetic biomarkers that may predict responsiveness to iNO in neonates with PPHN/HRF. The primary outcome will be identification of any biomarker(s) associated with response to iNO therapy.
- Trial name
- PINOR (NCT06043635)
- Sponsor
- Nationwide Children's Hospital
Heart Septal Defects, Ventricle, Heart Defects, Congenital
Genes Causing Ebstein's Anomaly
This study will investigate Ebstein's anomaly, a congenital abnormality of the tricuspid valve of the heart and try to identify the genetic origins of the disease.
- Conditions
- Heart Septal Defects, Ventricle, Heart Defects, Congenital, Double Outlet Right Ventricle, Truncus Arteriosus, Persistent
- Trial name
- NCT00497705
- Where
- 3 sites in United States, Belarus and 1 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Allergy to Peanut
Predictors of Persistent Peanut Allergy at Age 5 Years
The purpose of this study is to determine if avoidance of peanut by children with positive allergy testing to peanut in the first 5 years of life increases the likelihood of developing a persistent peanut allergy by age 5 years.
- Trial name
- NCT02497261
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Pain, Postoperative
Chronic Pain Following Thoracic Surgery
Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem.
- Trial name
- PTPS-18 (NCT01144845)
- Testing
- Thoracic surgery
- Where
- Denmark
- Volunteers
- 702 people
- Sponsor
- University of Aarhus
Asthma
Omalizumab in Adult and Adolescent Patients With Severe Persistent Allergic Asthma
Omalizumab will be given as add-on treatment to optimized asthma therapy in patients with severe persistent asthma, who demonstrate inadequate asthma symptom control.
- Trial name
- NCT00264849
- Testing
- Omalizumab, Optimized asthma therapy
- Where
- 17 sites in Belgium, Canada and 15 more
- Volunteers
- 406 people
- Sponsor
- Novartis
Diarrhea, Malnutrition
Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition
This is a double blinded randomized clinical trial of Alanyl-Glutamine or Glycine in children with persistent diarrhea or malnutrition.
- Trial name
- NCT00338221
- Testing
- alanyl-glutamine, glycine
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Diabetes Intervention Program for Adolescents With Persistent High HA1c
The purpose of this project is to assess the feasibility and efficacy of a new group therapy program for adolescents with Type 1 diabetes and compromised metabolic control (high A1c).
- Trial name
- NCT02212158
- Testing
- motivational interviewing group
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Asthma
Mechanisms Underlying Asthma Exacerbations Prevented and Persistent With Immune-Based Therapy
Asthma is a growing problem, especially in children. It causes frequent wheezing, shortness of breath, chest tightness, and cough. A cold that is caused by a virus (viral cold) can sometimes make asthma symptoms worse.
- Trial name
- MUPPITS-1 (NCT02502890)
- Where
- 9 sites in United States
- Volunteers
- 208 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Efficacy of Ciclesonide During the Cold Season in Patients Older Than 12 Years With Persistent Asthma
The aim of the study is to evaluate the efficacy of ciclesonide in patients with persistent asthma over 3 months, especially in the cold season. Ciclesonide will be inhaled by a metered-dose inhaler.
- Trial name
- ARTIST (NCT00608218)
- Testing
- Ciclesonide
- Where
- 153 sites in Germany
- Volunteers
- 2,100 people
- Sponsor
- AstraZeneca
New Daily Persistent Headache (NDPH), New Daily Persistent Headache
New Daily Persistent Headache Survey
Purpose: to explore headache characteristics and treatment effects of patient with new daily persistent headache (NDPH) through an online survey. Research design: Online survey of patients with new daily persistent headache.
- Trial name
- NDPH (NCT05984719)
- Where
- United States
- Volunteers
- 803 people
- Sponsor
- The University of Texas Health Science Center, Houston
Ovarian Cancer
Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Persistent Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy…
- Trial name
- NCT00002819
- Testing
- carboplatin, cyclophosphamide, mitoxantrone hydrochloride
- Where
- 64 sites in United States
- Sponsor
- Gynecologic Oncology Group
Cerebral Palsy
Intermittent Multifunctional Nutrition Tube in Cerebral Palsy and Dysphagia
This was a randomized controlled study including 80 infants with cerebral palsy and dysphagia. The Participants were evenly divided into the observation group (with intermittent oro-esophageal tube feeding, n=40) and the control…
- Trial name
- NCT06328972
- Testing
- systemic therapy, Intermittent Oro-Esophageal Tube Feeding, Persistent Nasogastric Tube Feeding
- Volunteers
- 100 people
- Sponsor
- Copka Sonpashan
Adults, Female
Pain Science Education for Labour and Postpartum Pain
This Delphi study aims to establish expert consensus on the role, content, and delivery of pain science education (PSE) for labour and postpartum pain management.
- Conditions
- Adults, Female, Labour Pain, Postpartum Pain
- Trial name
- PNE-DELPHI (NCT07096661)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Cervical Cancer
Oxaliplatin in Treating Patients With Recurrent or Refractory Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of oxaliplatin in treating patients who have recurrent or…
- Trial name
- NCT00005837
- Testing
- oxaliplatin
- Where
- 72 sites in United States, Canada
- Sponsor
- Gynecologic Oncology Group
Congenital Hyperinsulinism (CHI), Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI)
Phase II Safety and Efficacy Study of 18FDOPA PET-CT in Children With Hyperinsulinemic Hypoglycemia
Children with congenital hyperinsulinism (CHI) have low blood sugar, and some of these children may require surgery to remove part or all of their pancreas.
- Trial name
- 18FDOPA (NCT01468454)
- Testing
- 18 F-DOPA
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Children's Hospital of Philadelphia