Clinical trials: Personality Disorders
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Personality Disorder
Mentalization - Based Treatment: Adolescents With Co-morbid Depression and Personality Disorder
Mentalisation based treatment (MBT) for young people with co-morbid depression and emerging personality disorder will be more effective in a day/inpatient setting than treatment as usual.
- Trial name
- MBT (NCT01204346)
- Testing
- MBT, treatment as usual
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- North East London Foundation Trust
Self-esteem, Personality
Psychological Assessment of Adults Seeking Orthodontic Treatment
Is their a association between the objective and subjective severity of a malocclusion, quality of life and self-esteem/personality (as modifier between objective/subjective severity and quality of life (cfr study Agou et al.…
- Conditions
- Self-esteem, Personality, Quality of Life, Malocclusion
- Trial name
- NCT01475773
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Borderline Symptoms, Borderline Personality Disorder
The Effectiveness of Group Schema Therapy in the Treatment of Borderline Symptoms in Adolescents
The goal of this randomized and controlled trial is to assess the effectiveness of group schema therapy in the treatment of adolescents with borderline symptoms.
- Trial name
- NCT06606002
- Testing
- Group schema therapy, Treatment as Usual (TAU)
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Turku University Hospital
Psychopathic Personality Trait, Conduct Disorder
The Efficacy of a Compassion Focused Therapy-based Intervention in Detained Youth
This non-randomized controlled trial with a control group aimed to assess the efficacy of a 20-session individualized Compassion Focused Therapy-based intervention, the PSYCHOPATHY.COMP, in reducing psychopathic traits (primary…
- Conditions
- Psychopathic Personality Trait, Conduct Disorder, Delinquency
- Trial name
- PSYCOMP (NCT03971682)
- Testing
- PSYCHOPATHY.COMP program., Treatment As Usual - TAU
- Where
- Portugal
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Personality Disorders
Evolutionary Systems Therapy for Personality Pathology
Evolutionary Systems Therapy is a new form of therapy that has been previously tested in a randomized controlled trial and in a few cases of patients diagnosed with Cluster A personality disorders.
- Trial name
- ESTP (NCT06415812)
- Testing
- Evolutionary Systems Therapy
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Tages Onlus
Schizophrenia, Schizotypal Disorder
The OPUS YOUNG Trial. Early Intervention Versus Treatment as Usual for Adolescents With First-episode Psychosis
The OPUS YOUNG (OY) study investigates the efficacy of early intervention service versus treatment as usual (TAU) for adolescents aged 12-17 years with a first-episode psychosis.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Acute and Transient Psychotic Disorder, Unspecified
- Trial name
- OPUS-YOUNG (NCT04916626)
- Testing
- OPUS YOUNG, Treatment as Usual
- Where
- Denmark
- Volunteers
- 284 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Dual Diagnosis, Risk Youth
Virtual Reality (VR-GINSO) as an Complement to Intervention for Alcohol and Cannabis Use in Youth in Residential Care
The goal of this RCT is to evaluate the effects of a virtual reality intervention on self-efficacy regarding alcohol and cannabis use among at-risk youth in various residential mental health treatment centers who have…
- Conditions
- Dual Diagnosis, Risk Youth, Antisocial Behavior
- Trial name
- VR-GINSO (NCT07834606)
- Testing
- Virtual Reality, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad Francisco de Vitoria
Obsessive - Compulsive Disorder
Efficacy and Underlying Mechanisms of Group-Based Natural Psychotherapy for Anxiety Disorder
This study aims to preliminarily explore the intervention effect and feasibility of group natural psychotherapy (a new Eastern culture-based psychotherapy method) for patients with anxiety disorder through a randomized controlled…
- Trial name
- NCT07518264
- Testing
- Group-based Natural Psychotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing HuiLongGuan Hospital
Antisocial Behavior
Multisystemic Therapy-Emerging Adults Trial
This study's purpose is to test the effectiveness of a promising intervention for emerging adults (EAs) with mental illness (MI) and serious antisocial behavior in achieving the ultimate outcome of reduced antisocial behavior…
- Trial name
- MST-EA (NCT02922335)
- Testing
- Multisystemic Therapy for Emerging Adults, Enhanced Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 193 people
- Sponsor
- University of Massachusetts, Worcester
Borderline Personality Disorder in Adolescence
Dialectical Behavior Therapy for Adolescents at Rutgers University
This project expands our existing psychological services clinic (the Dialectical Behavior Therapy Clinic at Rutgers University; DBT-RU) to include an adolescent treatment arm.
- Trial name
- NCT03861858
- Testing
- DBT-A
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Rutgers, The State University of New Jersey
Prodromal Schizophrenia
Neurofeedback Training for High Risk Psychosis
Young people who are at great risk for developing psychosis have cognitive deficits which are strongly related to functioning in the community.
- Trial name
- NCT03447548
- Testing
- Neurofeedback processing speed training, Active control
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Hartford Hospital
Deliberate Self Harm
Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents
Deliberate Self-Harm (DSH) among adolescents is a serious behavioral problem associated with significant injury, impaired functioning, reduced quality of life, and high rates of psychiatric hospitalizations.
- Trial name
- NCT01111734
- Testing
- N-Acetylcysteine, fMRI
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Psychotic Disorders, Personality Disorders
The Staged Treatment in Early Psychosis Study
A sequential multistage randomised clinical trial (SMART) to produce evidence to guide a step-wise clinical approach for the treatment of ultra high risk patients and reduction of risk for psychosis and other deleterious clinical…
- Conditions
- Psychotic Disorders, Personality Disorders, Clinical High Risk
- Trial name
- STEP (NCT02751632)
- Testing
- Support and Problem Solving Therapy, Cognitive Behavioural Case Management, Fluoxetine
- Where
- 5 sites in Australia
- Volunteers
- 342 people
- Sponsor
- Orygen
Schizophrenia Spectrum and Other Psychotic Disorders, Bipolar and Related Disorders
Ascertaining Diagnosis Classification With Elicited Speech
Cross-sectional observational study of the relationship between speech patterns and psychiatric symptoms and disorders.
- Conditions
- Schizophrenia Spectrum and Other Psychotic Disorders, Bipolar and Related Disorders, Depressive Disorder, Anxiety Disorders
- Trial name
- ACES (NCT05601063)
- Testing
- Winterlight Speech Assessment
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Substance Use Disorders, Youth Protection Services
Adapting Personality-Targeted Interventions for Reducing Substance Misuse and Related Outcomes in Youth in Youth Protection Services
Substance use problems are major concern in adolescents involved in Youth Protection Services. However, there is an enormous gap between the needs and availability of interventions for youth with substance use problems in the…
- Conditions
- Substance Use Disorders, Youth Protection Services, Early Intervention, Prevention
- Trial name
- NCT04162977
- Testing
- Personality-targeted Interventions
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- St. Justine's Hospital
Psychotic Disorders, Prodromal Symptoms
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
The present study is a confirmatory efficacy trial of Family Focused Therapy for youth at clinical high risk for psychosis (FFT-CHR).
- Conditions
- Psychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, Psychosis
- Trial name
- NCT04338152
- Testing
- Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
- Where
- 7 sites in United States, Canada
- Volunteers
- 220 people
- Sponsor
- University of California, Los Angeles
Prodromal Schizophrenia
Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis
The Ohio State University Early Psychosis Intervention Center is implementing a specialized clinical program to serve individuals who meet clinical high risk criteria for a psychosis.
- Trial name
- NCT03970005
- Testing
- Step-Based Care Model
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Self Injurious Behavior Without Suicidal Intent, Self-Injurious Behavior
Genetics of Self-injurious Behaviour
Nonsuicidal Self-Injury (NSSI) is being increasingly regarded as a separate psychiatric disorder. Since the latest Diagnostic and Statistical Manual of Mental Disorders - DSM-5 from 2013 defined NSSI as a separate diagnosis under…
- Trial name
- NCT05563324
- Testing
- DNA extraction and genotyping of candidate genetic polymorphisms, self-assessment questionnaires
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Psychosis, Psychosis Nos/Other
EPI-MINN: Targeting Cognition and Motivation - National
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using…
- Conditions
- Psychosis, Psychosis Nos/Other, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05877716
- Testing
- Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Minnesota