Clinical trials: Pervasive Development Disorders
Autism Spectrum Disorder
The Predictors for Activity and Participation in Children With ASD: A Follow-up Study
Developmental function and Participation in life and school activities in patients with autism spectrum disorder: A follow-up study
- Trial name
- NCT03700190
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Irritability Associated With Autism Spectrum Disorder
Pimavanserin for the Treatment of Irritability Associated With Autism Spectrum Disorder
6-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group study in children and adolescents (aged 5 to17 years) with autism spectrum disorder (ASD) with irritability, agitation, or self-injurious behaviors…
- Trial name
- NCT05523895
- Testing
- Pimavanserin
- Where
- 57 sites in United States, Australia and 6 more
- Volunteers
- 237 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
ADHD, Autism Spectrum Disorder
AWARE: Management of ADHD in Autism Spectrum Disorder
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism.
- Trial name
- NCT05916339
- Testing
- Randomization to either Amphetamine (AMP) class of stimulant medication or Methylphenidate (MPH) class of stimulant medication, Randomization to either Alpha 2 agonist class of medication or alternate class of stimulant.
- Where
- 13 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Daniel Coury
Autism, Treatment Adherence
A Clinical Study Evaluating the Efficacy and Safety of Retinoic Acid in Patients With 15q11-q13 Duplication Syndrome
Autism Spectrum Disorders (ASD), with its core symptoms of communication and repetitive behaviors, is a serious neurodevelopmental disorder common in childhood and affects about 1% of children.
- Conditions
- Autism, Treatment Adherence, Retinoic Acid, Dup15Q Syndrome
- Trial name
- NCT05281965
- Testing
- Retinoic acid
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autism Spectrum Disorder, Other Neurodevelopmental Disorder
Early Assessment of Autism Through Smart Tablet Gameplay
The primary aim of this study is to compare the diagnostic accuracy of an iPad application (Play.Care assessment) with the current clinical "gold standard" diagnosis for diagnosis of Autism Spectrum Disorder (ASD) in children.
- Trial name
- NCT03438994
- Testing
- Play.Care
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- University of Strathclyde
Visual Rehabilitation, Visual Impairment, Autism Spectrum Disorder, Developmental Disabilities, Intellectual Disability, Behavioral Symptoms
Evaluation of a Program to Enhance Ophthalmic Compliance in Children and Adolescents With Special Needs
The goal of this clinical trial is to learn about the effects of the structured program incorporating contextual, behavioral, and cognitive strategies to improve compliance of children and adolescents with special needs during…
- Trial name
- NCT06717282
- Testing
- visual rehabilitation for ophthalmic compliance, Using contextual, behavioral, and cognitive-based stragegies to develop training programs
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
Tailoring Treatment Targets for Early Autism Intervention in Africa
Naturalistic Developmental Behavioral Interventions (NDBIs), an evidence-based early autism spectrum disorder (ASD) intervention approach, target key behaviors that help language development.
- Trial name
- NCT04068688
- Testing
- Early Start Denver Model (ESDM), Telehealth coaching
- Where
- South Africa
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep, Autism or Autistic Traits
Symptom-specific Effects of Omega-3 Across Neurodevelopmental Symptoms
Our study aims to determine whether omega-3 fatty acid supplementation can improve sleep, mood, and behavior in children with sleep problems and symptoms of Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder…
- Conditions
- Sleep, Autism or Autistic Traits, ADHD or ADHD Traits
- Trial name
- SEASONS (NCT06698588)
- Testing
- Omega 3 Fish Oil supplements
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Swansea University
Autism Spectrum Disorder, Autism
Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
- Conditions
- Autism Spectrum Disorder, Autism, Asperger Syndrome
- Trial name
- TMS for ASD (NCT04532424)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Stanford University
Autism Spectrum Disorder
Pilot Study of Sleep Therapy and Biomarkers in Children With Autism Spectrum Disorders
The purpose of this study is to test the combined effect of melatonin and donepezil on improving sleep and behavior in children with Autism Spectrum Disorders.
- Trial name
- NCT02487082
- Testing
- Melatonin and Donepezil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stony Brook University
Autism Spectrum Disorder
Intranasal Oxytocin for the Treatment of Children and Adolescents With ASD (OXY)
Extensive data has been accumulated to suggest that central release of oxytocin is important for social cognition and function, as well as likely involved in anxiety modulation and repetitive behaviors.
- Trial name
- NCT01256060
- Testing
- Intranasal Oxytocin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Evdokia Anagnostou
Autism Spectrum Disorder
Electrical Brain Stimulation and Pharmacological Treatments in Autism Spectrum Disorder
This project aims to comparing the effectiveness of transcranial direct current stimulation with common pharmacological treatments on behavioral problems and cognitive deficits of children with autism spectrum disorder
- Trial name
- NCT05491720
- Testing
- RisperiDONE 1 MG/ML, transcranial direct current stimulation
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Autism, Autism Spectrum Disorder
Intensive Intervention for Toddlers With Autism (EARLY STEPS)
Goals of the current project: (1) Does the Early Start Denver Model experimental intervention for toddlers with autism reduce disability associated with autism significantly more than standard community interventions?; and (2)…
- Trial name
- NCT00698997
- Testing
- Early Start Denver Model, Standard community care
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of California, Davis
Autism Spectrum Disorder (ASD), Transcranial Direct Current Stimulation (tDCS)
Transcranial Direct Current Stimulation in Children With Autism Spectrum Disorder
Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade.
- Conditions
- Autism Spectrum Disorder (ASD), Transcranial Direct Current Stimulation (tDCS), Electroencephalography
- Trial name
- NCT06880159
- Testing
- tDCS with computerized cognitive training
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Autism Spectrum Disorder
Tool for Evaluating the Effectiveness of the DENVER Protocol
Early remediation of the communicative and social difficulties of children with autism spectrum disorders (ASD) is central. However, from the age of 6-8 months, children with ASD show a lack of attention to social stimuli such as…
- Trial name
- FACECOM (NCT06253793)
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Autism
Study of Peer Relationships at School
The goal of this study is to compare the effects of two separate, manualized group interventions designed to improve social outcomes for young children with autism.
- Trial name
- HRSAII (NCT01011764)
- Testing
- SKILLS vs ENGAGE
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Health Resources and Services Administration (HRSA)
Autism Spectrum Disorder
Pivotal Response Treatment (PRT) Telemedicine
The purpose of this study is to evaluate the application of a modified version of PRT designed specifically as a parent-training model via telemedicine, with the goal of increasing access to empirically validated care.
- Trial name
- PRT (NCT03045263)
- Testing
- Pivotal Response Treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Autism Spectrum Disorder
Targeting Repetitive Behaviors in Autism Spectrum Disorder Via Transcranial Direct Current Stimulation
Repetitive behaviors (RBs) are a prevalent feature of Autism Spectrum Disorder (ASD). There are two groups of RBs: lower-order (e.g. motor stereotypies) and higher-order RBs (e.g.
- Trial name
- NCT06645587
- Testing
- Active HD-tDCS over pre-SMA, Active HD-tDCS over left DLPFC
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Autism, Autism Spectrum Disorder
Word Learning From Parentese in Autistic Children
The overall objective of this research is to determine whether parentese delivered in the video format (Aim 1) and in live interaction (Aim 2) facilitates novel word learning in autistic children and to investigate if there are…
- Conditions
- Autism, Autism Spectrum Disorder, Neurodevelopmental Disorders
- Trial name
- NCT06649916
- Testing
- Parentese Speech, Adult Registered Speech
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Autism Spectrum Disorder
Social Cognitive Development in Young Children With Autism
Through the development of a novel treatment targeting core Autism Spectrum Disorder (ASD) social deficits and studying the efficacy of this intervention, the investigators hope to provide a means for children with ASD to more…
- Trial name
- NCT01425918
- Testing
- Social Enhancement Intervention, Parent Education
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
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