Clinical trials: Photodynamic Therapy
Dental Caries
Effect of Photodynamic Therapy With Low-level Laser on Infected Dentin in Primary Teeth: A Controlled Clinical Trial
The aim of the proposed study is to assess the clinical effect of photodynamic therapy (PDT) on dentin with carious lesions in primary teeth.
- Trial name
- NCT02734420
- Testing
- PapacarieMBlue and PDT, Toluidine Blue O and PDT, Laser
- Where
- Brazil
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Halitosis
Assessment of Photodynamic Therapy With Annatto and Led for the Treatment of Halitosis in Mouth-Breathing Children
Objective: To assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children.
- Trial name
- NCT05590897
- Testing
- Teeth Brushing, Dental Flossing, Tongue Scraping
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- University of Nove de Julho
Actinic Keratosis
Daylight Photodynamic Therapy for Actinic Keratosis and Skin Field Cancerization
Twenty patients with multiple actinic keratosis on the face will be enrolled in the study and will be treated with Daylight Photodynamic therapy.
- Trial name
- NCT03013647
- Testing
- Methyl Aminolevulinate
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Skin Ulcer, Photodynamic Therapy
Low Concentration ALA-PDT in Treatment of Skin Ulcer
Skin ulcer is a common disease with complicated etiopathogenes, which makes it hard to be cured. It has been reported that photodynamic therapy (PDT) can be used to treat skin ulcers which were caused by different diseases.
- Trial name
- NCT04689243
- Testing
- ALA-PDT, red light
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sichuan Provincial People's Hospital
ALL, AML
Photochemotherapy and Graft-versus-leukemia in Acute-leukemia
Cure of leukemia after hematopoietic stem cell transplantation (HSCT) is sustained by the anti-leukemic effect of the grafted cells (graft-versus-leukemia (GVL)).
- Conditions
- ALL, AML, Acute GVHD, Tumor Immunity
- Trial name
- NCT02631993
- Testing
- Photochemotherapy
- Where
- Sweden
- Volunteers
- 47 people
- Sponsor
- Karolinska University Hospital
Periradicular Disease
Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy
The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.
- Trial name
- NCT02555488
- Testing
- diode laser, Methylene blue
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Health Care Associated Infection
Clinical Trial Evaluating Chlorine e6 Derivative-mediated Antimicrobial Photodynamic Therapy as a Treatment for Denture Stomatitis
Objective: This randomized clinical trial assessed antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) to treat patients with denture stomatitis (DS).
- Trial name
- NCT04532060
- Testing
- Nystatin, Antimicrobial Photodynamic Therapy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Chronic Central Serous Chorioretinopathy
Photodynamic Therapy Versus Eplerenone: Treatment Trial for Chronic Central Serous Chorioretinopathy
Chronic central serous chorioretinopathy (cCSC) is a relatively frequently occurring eye disease that is often diagnosed in patients in the professionally active age range.
- Trial name
- SPECT (NCT03079141)
- Testing
- Eplerenone, Photodynamic therapy
- Where
- 3 sites in Netherlands
- Volunteers
- 107 people
- Sponsor
- Leiden University Medical Center
Periodontal Diseases
Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down's Syndrome Patients
The aim of this study was to evaluate the effectiveness of antimicrobial photodynamic therapy as an adjuvant of scaling and root planning for treatment of periodontal disease in patients with Down's Syndrome.
- Trial name
- NCT02938988
- Testing
- Antimicrobial photodynamic therapy, Scaling and root planning, red laser
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo
Basal Cell Carcinoma, Basal Cell Nevus Syndrome
Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma
The purpose of this study is to study 50 patients with multiple Basal Cell Carcinoma (BCC) who will be receiving Photodynamic Therapy (PDT) as treatment for their tumors.
- Trial name
- NCT03467789
- Testing
- Dietary Vitamin D3 pre-treatment, Photodynamic therapy, Serum Maintenance Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Case Comprehensive Cancer Center
Teeth, Endodontically-Treated
Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth
The pulp necrosis of permanent immature teeth implies the interruption of the root formation and apical closure. Diode lasers have been used in many areas of dentistry, with tendency of good results in canal and dentine…
- Trial name
- NCT03074136
- Testing
- Photodinamic therapy, Diode laser, 0.5% Sodium hypochlorite
- Where
- Serbia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Association of Paediatric and Preventive Dentists of Serbia
Acne Vulgaris
Non-cutting Laser Therapy in the Treatment of Acne
The purpose of this research project is to study the effect of non-ablative (non-cutting) laser therapy, a technique that uses laser energy to try to improve the appearance of the skin.
- Trial name
- NCT00113425
- Testing
- V-Beam laser, Candela Corp., 595 nm wavelength
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Non-muscle Invasive Bladder Cancer
Clinical and Functional Consequences of Photodynamic Diagnosis (PDD) and Intravesical Instillation Therapy
The aim is to evaluate and compare treatment strategies for non-muscle invasive bladder cancer. Furthermore, the impact of intravesical instillations on bladder function will be examined by urodynamic examination both prior to…
- Trial name
- URODYN (NCT04943094)
- Testing
- Urodynamic examination
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Retinoblastoma
Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study
To study the effectiveness and safety profiles of photodynamic therapy (PDT) for the treatment of human retinoblastoma.
- Trial name
- NCT04429139
- Testing
- photodynamic therapy
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Sun Yat-sen University
Photochemotherapy Reaction
Photodynamic Therapy Against Candida Spp. in Complete Denture Wearers
Candida albicans is the most prevalent species in denture-related stomatitis (DS). There are several treatment options for this condition, including the use of antifungal agents such as nystatin and miconazole.
- Trial name
- NCT02642900
- Testing
- Photodynamic Therapy, Nystatin 100.000 units
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Port-Wine Stain
Effect of Pulsed Dye Laser on Photodynamic Therapy of Port-Wine Stains
Port-wine stain (PWS) is a congenital capillary malformation with an incidence of 3-5/1000 newborns and grows commensurately with the affected individual.
- Trial name
- NCT04536740
- Testing
- PDT treatment device
- Volunteers
- 68 people
- Sponsor
- Gang Ma
Acne Vulgaris
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Moderate to Severe Acne
This multicenter study will be divided into 2 phases. The first phase will be an open label, dose-escalation phase, while the second will be a blinded, randomized, vehicle-controlled, parallel-group, dose-response phase.
- Trial name
- NCT00594425
- Testing
- Methyl aminolevulinate (MAL) PDT
- Where
- 14 sites in United States
- Volunteers
- 150 people
- Sponsor
- Photocure
Carcinoma, Basal Cell, Porokeratosis, Disseminated Superficial Actinic
Cytodiagnosis of Basal Cell Carcinoma and Actinic Keratosis Using Papanicolaou and May-grunwald-giemsa Stained Tissue Smear
The purpose of this study is to compare and evaluate the diagnostic performance of scrape cytology using two different cytological staining techniques, and to evaluate additional touch imprint cytology with that of histopathology…
- Trial name
- NCT00218868
- Testing
- Skin scrape
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- Norwegian University of Science and Technology
Acne Vulgaris
Conventional Photodynamic Therapy Versus Daylight Photodynamic Therapy for The Treatment of Acne Vulgaris
Photodynamic therapy (PDT) is considered an effective treatment for acne vulgaris. The study aims to determine whether treatment with daylight as an illumination source is as effective as conventional, red light illumination.
- Trial name
- NCT04631250
- Testing
- 5-Aminolevulinic Acid-Containing Product in Cutaneous Dose Form
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Root Canal Disinfection
Estimate the Effect of aPDT on Root Canal Disinfection
The aim of this study is to compare the clinical effect of traditional root canal disinfection and aPDT on root canal disinfection. And provide the reference for clinical application and experience.
- Trial name
- NCT02929927
- Testing
- Rubber dam isolation, aPDT, 1% iodine tincture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University