Clinical trials: Photosensitivity
Cockayne Syndrome, Skin Neoplasms
Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility.
- Conditions
- Cockayne Syndrome, Skin Neoplasms, Xeroderma Pigmentosum, Trichothiodystrophy Syndromes
- Trial name
- NCT00001813
- Where
- United States
- Volunteers
- 709 people
- Sponsor
- National Cancer Institute (NCI)
Xeroderma Pigmentosum
XPAND Trial: Enhancing XP Photoprotection Activities - New Directions
People with Xeroderma Pigmentosum (XP) have a genetic condition which stops their skin repairing damage from Ultraviolet Radiation (UVR). This means they are much more likely to develop potentially fatal skin cancers.
- Trial name
- XPAND (NCT03445052)
- Testing
- XPAND
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Sunburn, Skin Cancer Prevention
Sun Safety Skills for Elementary School Students
The overarching goal of this work is to pilot-test a song-based instructional video designed to help elementary school (kindergarten) age children independently apply sunscreen effectively (i.e., covers all needed areas)…
- Trial name
- NCT03752736
- Testing
- "I wear sunscreen everyday" song-based video
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sunburn
Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Sunburn Related Symptoms
Topical antihistamines can be used to promote relief of sunburn related symptoms (erythema, itch and burning sensations). Dexchlorpheniramine maleate 1% cream is a topical antihistamine formulation approved by ANVISA in Brazil…
- Trial name
- NCT01085851
- Testing
- Dexchlorpheniramine 1% lotion, Dexchlorpheniramine 1% cream
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
DNA Repair Disorder, Cockayne Syndrome
Natural History Study for DNA Repair Disorders
This will be a single-center, single-arm, non-interventional natural history study to evaluate the longitudinal clinical course, functional outcome measures, and candidate biomarkers for individuals with DNA repair disorders…
- Conditions
- DNA Repair Disorder, Cockayne Syndrome, Xeroderma Pigmentosum, Trichothiodystrophy
- Trial name
- NCT05484570
- Testing
- Interval History, Physical Examination, ECAB Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Erythropoietic Protoporphyria, X-linked Protoporphyria
Effect of Oral Cimetidine in the Protoporphyrias
Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) result from genetic defects of heme biosynthesis that cause life-long, painful cutaneous sensitivity to light.
- Trial name
- NCT05020184
- Testing
- Cimetidine
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Amy K. Dickey, M.D.
Reflex Epilepsy, Photosensitive, Eyeglasses
Efficacy of Lenses in Abolishing Photoparoxysmal Responses
Background. Blue lenses that filter out red light have been proposed as a new therapeutic alternative for patients with PSE, such as the lens Zeiss Clarlet Z1.
- Trial name
- PPRs (NCT04076410)
- Testing
- Z1 lens, Experimental Lens 1, Experimental Lens 2
- Where
- 2 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- Aston University
Xeroderma Pigmentosum, Basal Cell Carcinoma
Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum
This study will determine if family members of patients with xeroderma pigmentosum (XP) have various abnormalities, including: skin abnormalities; nervous system abnormalities, such as hearing problems; skin, eye, or internal…
- Conditions
- Xeroderma Pigmentosum, Basal Cell Carcinoma, Squamous Cell Carcinoma, Melanoma
- Trial name
- NCT00046189
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- National Cancer Institute (NCI)
Ichthyosis, Palmoplantar Keratoses
Reproductive Options in Inherited Skin Diseases
The goal of this observational study is to learn about the indications for prenatal diagnostics and preimplantation genetic testing for patients/couples affected by an inherited skin disease, and evaluate the clinical outcomes of…
- Conditions
- Ichthyosis, Palmoplantar Keratoses, Epidermolysis Bullosa, Ectodermal Dysplasia
- Trial name
- REPRO-ISD (NCT06330324)
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Maastricht University Medical Center
Healthy Volunteers, Fungal Infections
A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity
This study will examine the phototoxicity, a reaction to light that is like exaggerated sunburn, which occurs in people who take medications such as voriconazole, a medication used to fight fungus.
- Conditions
- Healthy Volunteers, Fungal Infections, Bacterial Infections
- Trial name
- NCT00353158
- Testing
- Doxycycline, Voriconazole
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Constitutional Mismatch Repair Deficiency Syndrome, Hematopoietic and Lymphoid Cell Neoplasm
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study
This phase Ib trial investigates the side effects of the combination of nivolumab and ipilimumab, and to see how well they work in treating patients with cancers that have come back (relapsed) or does not respond to treatment…
- Conditions
- Constitutional Mismatch Repair Deficiency Syndrome, Hematopoietic and Lymphoid Cell Neoplasm, Lynch Syndrome, Recurrent Lymphoma
- Trial name
- NCT04500548
- Testing
- Biospecimen Collection, Ipilimumab, Nivolumab
- Where
- 9 sites in United States, Canada
- Sponsor
- National Cancer Institute (NCI)
Sunburn, Sun Damaged Skin
Natural Sunlight Protection and Simulated Sunlight Protection Offered by Sunscreens and Fabrics
The purpose of this study is to assess how human skin reacts and how sunscreens and sun protection fabrics protect in natural sunlight compared to their labeled claims, indoor testing methods (existing or modified) and…
- Conditions
- Sunburn, Sun Damaged Skin, Overexposure to Sun Rays
- Trial name
- NCT03007589
- Testing
- otc sunscreens, sun protection fabrics, Optical Filters
- Where
- 5 sites in United States, Chile and 1 more
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Protection Foundation
Sunburn
Clinical Safety Trial of Long-Term Intermittent Use of Helioblock® SX Cream
The purpose of this study is to determine the safety potential of Helioblock® SX Cream as a sunscreen product in long term intermittent use conditions among pediatric subjects..
- Trial name
- NCT00326274
- Testing
- Helioblock® SX Cream
- Where
- United States
- Sponsor
- Loreal USA
Xeroderma Pigmentosum
Xeroderma Pigmentosum Patient Experiences
Xeroderma Pigmentosum (XP) is a rare skin condition that causes extreme sensitivity to the sun and an increased incidence of skin cancers.
- Trial name
- NCT01123694
- Testing
- Survey Study
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Henry Ford Health System
Sunburn
Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Gel) in the Relief of Sunburn Related Symptoms
Topical antihistamines can be used to promote relief of sunburn related symptoms (erythema, itch and burning sensations). Dexchlorpheniramine maleate 1% cream is a topical antihistamine formulation approved by ANVISA in Brazil…
- Trial name
- NCT01237925
- Testing
- Dexchlorpheniramine 1% gel, Dexchlorpheniramine 1% cream
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
Photosensitivity Disorders
Skin Aging in Renal Transplant Patients
Determination of collagen, pigment and haemoglobin content of sun exposed and sun protected skin by Siascopy. Immunocompromised patients (for more than seven years) compared to immunocompetent patients.
- Trial name
- NCT01776983
- Testing
- Photosensitivity under the influence of immunocomp
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich