Clinical trials: Pigmentation Disorder
Vitiligo
Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo
The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin.
- Trial name
- NCT07398807
- Testing
- Microneedling with 5-fluorouracil, Topical application of 0.05% Clobetasol propionate
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan
Acanthosis Nigricans, Hyperinsulinemia
Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia
Acanthosis Nigricans is skin disease that associated with hyperinsulinemia. Clinical is velvety hyperpigmented plaques on neck, axilla, groin.
- Conditions
- Acanthosis Nigricans, Hyperinsulinemia, Spectroscopic Analysis
- Trial name
- NCT01125150
- Testing
- Metformin, Dietary Modification
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vitiligo
Microneedling Combined With Topical Crisaborole 2 % Ointment in Treatment of Vitiligo.
The goal of this clinical trial is to learn if topical crisaborole ointment works to treat vitiligo. It will also learn about the safety of the drug.
- Trial name
- NCT07088276
- Testing
- microneedling with topical crisaborole
- Volunteers
- 20 people
- Sponsor
- Tanta University
Diabetes Mellitus
Adjunctive Metformin Therapy in Double Diabetes
The significance of this project is to investigate the effects of adjunctive metformin therapy in children and adolescents with double diabetes.
- Trial name
- AMTIDD (NCT01334125)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Massachusetts, Worcester
Peutz-Jeghers Syndrome
Chinese Multicenter Registry for Peutz-Jeghers Syndrome
This prospective, observational patient registry will enroll approximately 1,000 individuals with a clinical or molecular diagnosis of Peutz-Jeghers syndrome (PJS) at participating hospitals in China.
- Trial name
- NCT07889596
- Where
- 9 sites in China
- Volunteers
- 1,000 people
- Sponsor
- First People's Hospital of Hangzhou
Vitiligo
Exosomal Markers CD63 and CD9 in Vitiligo Before and After NB-UVB Therapy
This study evaluated the expression of the exosomal markers CD63 and CD9 in the skin of patients with vitiligo and assessed changes in their expression after narrow-band ultraviolet B (NB-UVB) therapy.
- Trial name
- NCT07796893
- Testing
- Narrow-Band Ultraviolet B (NB-UVB) Therapy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Amany El-Agamy Ibrahim El-Samadony
Dermatologic Disease, Vitiligo
Comparison of Cyclic On-off and Continuous Excimer Laser Treatment for Vitiligo
OBJECTIVE: To investigate the efficacy of the cyclic on-off treatment compared to the conventional continuous excimer laser treatment. DESIGN: A randomized, controlled, split-body, non-inferiority study.
- Trial name
- NCT03047733
- Testing
- The XTRAC Excimer Laser System, Topical tacrolimus 0.1% ointment
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Ajou University School of Medicine
Oculocutaneous Albinism
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism
Oculocutaneous albinism (OCA) is a term used to describe inherited forms of hypopigmentation associated with 1) variable levels of cutaneous hypopigmentation, ocular hypopigmentation, and visual deficits, and 2) involvement of…
- Trial name
- NCT00808106
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Pressure Injuries, Pressure Ulcers, Bedsores, Decubitus Ulcer
Prevention of Pressure Injury (PI) in Hospitalised Infants, Children, and Young People (CYP) (Aged 0-19 Years)
What is the problem? Children and young people admitted to hospital can sometimes be harmed by what is called a pressure injury. Pressure injuries are sores (ulcers) that happen on areas of the skin that are under pressure.
- Trial name
- CYPPI (NCT07303569)
- Where
- United Kingdom
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Vitiligo, CD25 Deficiency
Tregs CD25 CXCL9 in Vitiligo
Clinical significance of circulating T regulatory cells , soluble CD25 and CXCL9 to assess disease activity of vitiligo.
- Conditions
- Vitiligo, CD25 Deficiency, Chemokine (C-X-C Motif), Tregs
- Trial name
- NCT05569096
- Testing
- ELIZA , Flowcytometry
- Volunteers
- 40 people
- Sponsor
- Assiut University
Vitiligo
A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo
The CUV105 study will assess the efficacy and safety of afamelanotide and NB-UVB light in patients with vitiligo on the body and face versus NB-UVB light alone.
- Trial name
- NCT06109649
- Testing
- Afamelanotide and NB-UVB Light, NB-UVB Light
- Where
- 30 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Clinuvel, Inc.
Vitiligo - Macular Depigmentation
0.005% Latanoprost Gel for Nonsegmental Vitiligo
Latanoprost, a prostaglandin F2α (PGF2α) analog used for glaucoma treatment, is known to cause iris darkening, hypertrichosis, and periocular skin hyperpigmentation.
- Trial name
- NCT07016113
- Testing
- 0.005% latanoprost gel, 0.1% mometasone furoate cream
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Padjadjaran
Hyperpigmentation, Pediatric Dermatology
A Study on Pigmentation Disorders in Children
The descriptive cross-sectional study was undertaken at Kanti Children's Hospital during the period from January 2020 to June 2021.
- Trial name
- NCT06189768
- Where
- Nepal
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Nepal Health Research Council
Vitiligo
Effects of Combination Therapy With Camouflage in the Repigmentation of Vitiligo
Vitiligo is a common depigmented skin disorder characterized by the white patches of skin and mucous membrane. It can be cosmetically disfiguring and lead to serious psychological problems for patients with vitiligo.
- Trial name
- NCT03973073
- Testing
- CapulinTM, topical applications and NB-UVB
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Urticaria Pigmentosa, Cutaneous Mastocytosis
Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations
Pediatric mastocytosis is an orphan disease, which encompasses several clinically distinct entities including solitary mastocytoma, urticaria pigmentosa, diffuse cutaneous mastocytosis and the newly recognized mast cell…
- Trial name
- NCT02761473
- Testing
- skin biopsy, blood draw
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Vitiligo
Effect of Early Systemic Stabilization Therapy on Recent Onset Vitiligo
Vitiligo is a distressing disorder of depigmentation. In spite of multiple successful therapeutic regimens, disease relapse remains a challenge to patients and physicians.
- Trial name
- NCT05037981
- Volunteers
- 25 people
- Sponsor
- Cairo University
Vitiligo Vulgaris
Efficacy and Safety of Pimecrolimus for the Treatment of Vitiligo Vulgaris
Patients with vitiligo vulgaris are treated with Pimecrolimus twice a day during 6 months. After a baseline visit, patient returns for a control visit after 3 and 6 months of treatment.
- Trial name
- NCT00372307
- Testing
- Application of pimecrolimus
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- University Hospital, Ghent
Neurofibromatosis Type 1
Function of the Pigment Epithelium in Patients With Type 1 Neurofibromatosis
The objective of this study is to study the function of the pigment epithelium in patients with neurofibromatosis type 1 using electro-oculogram to confirm abnormally high values reported in previous studies, but also to…
- Trial name
- NEF-1 (NCT04153344)
- Testing
- Electro-oculogram, Full-field electroretinogram
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
LCA (Leber Congenital Amaurosis), RP (Retinitis Pigmentosa)
Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)
The purpose of this study is: To evaluate the safety of up to 3 additional courses of oral QLT091001 administered once daily for 7 days in subjects treated previously with a single 7-day course of QLT091001 in Study RET IRD 01 To…
- Trial name
- NCT01521793
- Testing
- QLT091001
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 27 people
- Sponsor
- QLT Inc.
Inherited Epidermolysis Bullosa, Ichthyosis
FARD (RaDiCo Cohort) (RaDiCo-FARD)
The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical)…
- Conditions
- Inherited Epidermolysis Bullosa, Ichthyosis, Ectodermal Dysplasia, Incontinentia Pigmenti
- Trial name
- FARD (NCT05954416)
- Where
- 15 sites in France
- Volunteers
- 900 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France