Clinical trials: Polymorphism-Genetic
Healthy
Pharmacogenetics Study in Taiwan's Ethnic Groups
This main purpose of this study is to understand the difference and distribution of drug-metabolizing enzyme genetic polymorphisms among Taiwan ethnicities.
- Trial name
- NCT00459251
- Where
- Taiwan
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Polymorphism, Restriction Fragment Length, Premature
Neurological Fate, Prematurity and Genetic Susceptibility Factors
This study could help identify aggravating or protective genetic polymorphisms associated with cerebral palsy. Populations of premature babies at different risk of cerebral palsy could thus be individualized with an impact on…
- Conditions
- Polymorphism, Restriction Fragment Length, Premature, Infertility of Cervical Origin
- Trial name
- GENIMOC (NCT04298346)
- Testing
- no intervention
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Nantes University Hospital
Genetic Polymorphism Connected to Top-level Swimmers
Genetic Polymorphism and Israeli Top-level Swimmers' Performance and Expertise
In a study conducted in our laboratory few years ago, we genotyped 22 genes in 2 athletic groups (endurance and sprinters) and in age and gender matched nonathletic controls.
- Trial name
- NCT01319032
- Testing
- Extraction of whole blood
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Infections
The Role of Genetic Polymorphisms in Innate Immune Response Genes in Susceptibility to Infections
The purpose of this study is to better understand genetic susceptibility to infections and the interactions of specific genetic polymorphisms of innate immune receptors with microbial and fungal organisms.
- Trial name
- NCT00597090
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Self Injurious Behavior Without Suicidal Intent, Self-Injurious Behavior
Genetics of Self-injurious Behaviour
Nonsuicidal Self-Injury (NSSI) is being increasingly regarded as a separate psychiatric disorder. Since the latest Diagnostic and Statistical Manual of Mental Disorders - DSM-5 from 2013 defined NSSI as a separate diagnosis under…
- Trial name
- NCT05563324
- Testing
- DNA extraction and genotyping of candidate genetic polymorphisms, self-assessment questionnaires
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Crohn Disease, Pediatric Crohns Disease
Autophagy in Paediatric Crohn's Disease
Crohn's disease is a multifactorial complex disease resulting in a between microbiota and immune system. Indeed, GWAS (Genome-Wide Association Studies) association study pinpointed polymorphisms as genes susceptibility on more…
- Trial name
- P-IBDphagy (NCT05842564)
- Testing
- Blood samples, Biopsies
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Developmental Delays
The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays
The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.
- Trial name
- NCT02523989
- Testing
- study group
- Where
- Taiwan
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Congenital Heart Disease
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy
There are many kids born with congenital heart disease. Some of these defects may lead to the formation of a single ventricle (the heart having only one pumping chamber).
- Trial name
- NCT00165984
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Emory University
Gastric Ulcer, Duodenal Ulcer
Cytokine Gene Polymorphisms in Gastric Diseases
Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer.
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Gastric Cancer
- Trial name
- NCT00197470
- Testing
- IL-1, TNF-alpha, Il-10
- Where
- Japan
- Sponsor
- Hamamatsu University
Neonatal Respiratory Distress Syndrome
Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome
Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells.
- Trial name
- NCT02333669
- Testing
- no intervention
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Collecting and Storing Blood Samples From Patients With Cancer
RATIONALE: Collecting and storing samples of blood from patients with cancer to test in the laboratory may help the study of cancer in the future.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00900120
- Sponsor
- University of Medicine and Dentistry of New Jersey
Chronic Hepatitis C
A Randomized Trial of 24-Week Versus 48-Week Courses of Peginterferon Plus Ribavirin for Patients With Genotype 1 Hepatitis C and IL28B CC Polymorphism
Patients with HCV genotype 1 and IL28B CC Polymorphism who have a rapid virological response to treatment are randomised to either 24 or 48 weeks HCV treatment.
- Trial name
- NCT01441804
- Testing
- Peginterferon alfa2a, Ribavirin
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Parkinson's Disease
Genetic Polymorphism and Parkinson's Disease in Taiwanese
To observe and analyze the correlation between Single Nucleotide polymorphisms (SNPs) and the incidence of Parkinson's disease in Taiwanese.
- Trial name
- NCT01996878
- Where
- Taiwan
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
ICD, Arrythmia
Genome-Wide Association Study With the Aim of Implantable Cardioverter Defibrillator Implantation Genophenotypic Risk Stratification
This clinical study will be conducted with funding from European Innovation Council(EIC) after approval of the fund grant and is part of our organization's European Pathfinder Project(Ref…
- Conditions
- ICD, Arrythmia, Sudden Cardiac Death
- Trial name
- ICDGPSS (NCT05582252)
- Testing
- Non-Invasive saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Renal Transplant
Influence of Genes on Sirolimus Metabolism in Patients With Kidney Transplantation
This study will evaluate the effects of certain genes (MDR-1, CYP3A4, and CYP3A5) on metabolism of the drug sirolimus, an immune-suppressing drug given to transplant recipients to prevent organ rejection.
- Trial name
- NCT00352547
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Allergic Conjunctivitis
The Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic Conjunctivitis
A double-blind study to evaluate the role of vitamin D in corneal epithelial barrier function, ocular microbiome, ocular inflammation, and visual acuity of children with allergic conjunctivitis.
- Trial name
- NCT05839938
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Kidney Diseases
Practical Use of Advagraf de Novo After Kidney Transplantation According to Recipient Genetic Polymorphism
To optimize the Advagraf (tacrolimus once a day) initial daily dose used in de novo after kidney transplantation in combination with MMF (or MPA) and corticosteroids (CS) regarding of the genetic Cyp 450 3A5 polymorphism of the…
- Trial name
- CYRANO (NCT02311010)
- Testing
- Advagraf
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Université Catholique de Louvain
Autism Spectrum Disorder
Study of the Genetic Factors Involved in Autism and Related Disorders
The main objective of the study is to define, for Autism Spectrum Disorder, the extent of genetic variation in synaptic pathways that may be targeted for therapeutic development.
- Trial name
- Gene&autism (NCT04727489)
- Testing
- DNA from subjects will be stored in the biobank of our study.
- Where
- 6 sites in France
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France