Clinical trials: Polyphenols
Hypertension
Antihypertensive and Cardioprotective Evaluation of a Functional Olive Oil
The general objective of this study is to evaluate the effect of a nutritional intervention with an extra virgin olive oil (EVOO) rich in bioactive compounds (polyphenols) and a functional oil of adequate organoleptic quality…
- Trial name
- NCT05460221
- Testing
- Optimized oil group, Functional oil group, Control group
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Hypercholesterolemia
Hypocholesterolemic Effect of a Phytosterol-enriched Spreadable Cream Prepared With Virgin Olive Oil
This study aims to evaluate the effect of the enriched extra virgin olive oil spread in plant sterols from the olive itself and demonstrate its effect anticholesterolemic and cardioprotective in children and adolescents with…
- Trial name
- NCT05460208
- Testing
- Enriched spread, Control spread
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Bioavailability
Bioavailability of Ration Items Containing Tart Cherry Extract
To determine how consuming food items containing shelf-stored tart cherry impacts your body's ability to absorb and use the compounds within tart cherry.
- Trial name
- Tart Cherry (NCT07063173)
- Testing
- Fruit Bar, Powdered Drink, Commercially available 100% tart cherry juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Oral Lichen Planus
Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus
Is topical application of green tea polyphenols buccal tablet more effective in treatment of patients with symptomatic oral lichen planus in comparison with topical application of corticosteroids and what is the most effective…
- Trial name
- NCT03415165
- Testing
- green tea buccal tablet, Corticosteroids Topical
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pediatric Obesity, Puberty, Precocious
The Effect of Decaffeinated Green Tea Polyphenol Intake on the Risk of Precocious Puberty Among Obese Girls
In this study, 6-10 years old obese girls will be recruited to test the preventive effect of decaffeinated green tea polyphenols on the risk of precocious puberty by the random, placebo-control and single blind design.
- Trial name
- NCT03628937
- Testing
- Decaffeinated Green Tea Polyphenol
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Stage I Prostate Cancer, Stage IIA Prostate Cancer
Aborption and Metabolism of Lyophilized Black Raspberry Food Products in Men With Prostate Cancer Undergoing Surgery
This Phase I/Ib trial is studying the absorption and metabolism of phytochemicals found in black raspberries in men undergoing surgery for prostate cancer.
- Conditions
- Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer
- Trial name
- NCT01823562
- Testing
- lyophilized black raspberry confection, laboratory biomarker analysis, dietary intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Intervention
Intervention Effect of TP and AOB-w on Acrylamide Exposure in Chinese Adolescents
A double-blind randomized controlled trial (RCT) was conducted in current human study. This study aims to investigate the intervention effect of AOB-w on the short-term exposure and toxicokinetics of acrylamide, a dietary…
- Trial name
- NCT03118167
- Testing
- Tea polyphenols, AOB-w, Acrylamide (Potato Chips)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Obesity, Childhood, Hepatic Steatosis
Effect of Polyphenol Supplementation on Hepatic Steatosis and Vascular Compliance
The main objective is to study the effect of polyphenol supplementation on hepatic steatosis as measured by hepatic ultrasound, hepatic magnetic resonance imaging and on intima-media thickness and vascular elastography in obese…
- Conditions
- Obesity, Childhood, Hepatic Steatosis, Intimal Hyperplasia
- Trial name
- NCT03994029
- Testing
- Effect of polyphenols on hepatic steatosis and vascular elastography and intima media thickness
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Justine's Hospital
Genotype, Metabotype and Dietary Habits
Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.
The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort…
- Trial name
- PolyMicroBio (NCT03318042)
- Testing
- Walnuts, Pomegranate juice
- Where
- Spain
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Healthy
The Blueberry Study
This is a research study about the effects of blueberries on the health of children who do not eat much fruits and vegetables. By doing this study, we hope to find out what nutrients from blueberries appear in the blood and urine…
- Trial name
- NCT04421950
- Testing
- Wild blueberry containing foods
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
ADHD
Effect of Pycnogenol® on ADHD
This double blind, randomised controlled trial examines the effect of a commercially available nutritional supplement on behaviour of ADHD patients, as well as on their physical and psychiatric co-morbidities, and level of…
- Trial name
- NCT02700685
- Testing
- Pycnogenol, Methylphenidate
- Where
- 3 sites in Belgium
- Volunteers
- 88 people
- Sponsor
- Nina Hermans
Oxidative Stress, Muscle Fatigue
Effect of Grape Juice Consumption on the Parameters of Oxidative Stress and Muscle Fatigue in Judo Athletes
This project aims to evaluate if after 14 days of grape juice ingestion there is improvement of the parameters of strength, fatigue and oxidative stress in judo fighters.
- Conditions
- Oxidative Stress, Muscle Fatigue, Polyphenol, Free Radical Oxidation of Tissue
- Trial name
- NCT03186573
- Testing
- Grape juice, Maltodextrin
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Healthy
Acute and Chronic Effects of 100% Florida Orange Juice Consumption on Cognitive Performance in 7-10 Year Old Children
This study is a 10-week intervention study to examine the acute and chronic effects of daily intake of a 100 % orange juice drink vs control drink on cognitive performance.
- Trial name
- NCT02725775
- Testing
- 100% Florida OJ
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
ADHD - Attention Deficit Disorder With Hyperactivity
Study of the Nutritional, Inflammatory, and Metabolic Endophenotypes of Attention-Deficit/Hyperactivity Disorder (ADHD)
This study aims to better understand the biological mechanisms involved in attention deficit hyperactivity disorder (ADHD) and to clarify why some children and adolescents respond well to methylphenidate (MPH)-the most commonly…
- Trial name
- ANIME (NCT07417878)
- Testing
- Clinical and Biological Evaluation - ADHD Cases, Clinical and Biological Evaluation - Controls
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Healthy Volunteers
Grape Polyphenol Kinetics in Humans
The objectives of this study are the following: 1) to confirm that the administration of grape juice, resveratrol, and grape seed polyphenol extract results in a similar plasma and urinary metabolic profile in aged humans…
- Trial name
- NCT01751750
- Testing
- Grape
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janet Novotny
Skill Performance, Soccer Performance
Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players
This study of soccer skill performance has three objectives: 1. Compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision, passing speed and accuracy, and sprint speed during a full simulated…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT05547204
- Testing
- Beverage
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Hypertension
The Effect of Cocoa Flavonoids on Blood Pressure
The purpose of this study is to compare the effects on blood pressure of a daily intake of a flavonoid-rich cocoa drink with that of the same drink from which the flavonoids have been largely extracted.
- Trial name
- NCT00125866
- Testing
- Flavonoid rich or flavonoid depleted chocolate drink
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Skill Performance, Soccer Performance
Influence of Coffeeberry Ingestion on Soccer Skill Performance
The study of soccer skill performance has 3 objectives. Objective 1 is to compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision and passing and shooting speed and accuracy compared to…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT04181619
- Testing
- Coffeeberry beverage, Comparator beverage
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Anemia, Low Iron Stores
Improving Iron Status Through Consumption Of Iron Fortified Cowpea: An Intervention Study
Rationale: Iron deficiency and zinc deficiency, are of public health significance in sub-Saharan Africa. An estimated 50% of children (5-14 years) in developing countries suffer from anaemia, half of which is estimated iron…
- Trial name
- NCT01208363
- Testing
- Cowpea fortified with NaFeEDTA, in form of Toubani.
- Where
- Ghana
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Wageningen University