Clinical trials: Post-Surgical Complication
Pain, Postoperative
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
This is a prospective, randomized, double-blinded, placebo controlled trial Potential subjects will be identified from the Pre-Surgical Anesthesia Clinic visit.
- Trial name
- IV APAP SF (NCT01394718)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital of Philadelphia
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Around 7500 neonates born yearly in the United States have complex congenital heart disease that require surgical repair in the first few days of life.
- Trial name
- NCT02151877
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain, Acute Pain
Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain
To find out if a drug called tapentadol administered by mouth safely relieves pain in children. Look at the amount of tapentadol in the blood after a single oral dose.
- Trial name
- NCT01729728
- Testing
- Tapentadol
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Grünenthal GmbH
Postoperative Pain
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management
To evaluate the efficacy of bilateral continuous erector spinae blocks (BESB) for postoperative analgesia in children and adolescents undergoing cardiac surgical procedures via sternotomy in the Early Recovery After Surgery…
- Trial name
- NCT04567407
- Testing
- Bilateral erector spinae blocks using ropivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Supracondylar Humerus Fracture, Post Operative Wound Infection
Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS)
The aim of this study is to determine if antibiotics affect the outcome after percutaneous surgery for pediatric supracondylar humerus fractures.
- Trial name
- NCT03261830
- Testing
- Cefazolin, Clindamycin, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Sumit Gupta
Cesarean Section
Comparison Study of Wound Closure at Time of Cesarean Delivery: Dermabond Glue Versus Surgical Staples
Women who have a cesarean delivery have a surgical incision on their abdomen (belly). The usual way to close this opening is with metal surgical staples.
- Trial name
- NCT00524511
- Testing
- Surgical skin staples, Dermabond
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Massachusetts, Worcester
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Acute Kidney Injury
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery
Children with congenital heart defects often need cardiac surgery with cardiopulmonary bypass (the "heart-lung machine"). Approximately 35 to 50% of these children will have "acute kidney injury," or damage to the kidneys, after…
- Trial name
- KIDPROAM (NCT01245595)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Stanford University
Pain, Pain, Postoperative
Biofeedback Based Virtual Reality Intervention to Manage Postoperative Pain
To develop and refine a technology based treatment protocol for preoperative education and training and postoperative care in children and adolescents undergoing surgery.
- Conditions
- Pain, Pain, Postoperative, Pain, Acute, Surgery
- Trial name
- NCT04943874
- Testing
- Technology Based Intervention Group 1, Technology Based Intervention Group 2
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Vanessa Olbrecht
Pain, Postoperative, Hernia, Inguinal
Surgical Pain After Inguinal Hernia Repair (SPAIHR)
The purpose of this study is to test whether pregabalin added to the standard of care with dosing starting preoperatively and continuing for 1 week post surgery will decrease the intensity of acute post-operative pain following…
- Trial name
- NCT00551135
- Testing
- Pregabalin
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 425 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Impacted Mandibular Third Molar, Edema
Single-Session Extraoral PBM After Third Molar Extraction
Postoperative pain, edema, and trismus are frequent complications following impacted mandibular third molar surgery. This randomized controlled trial evaluated the effects of a single-session extraoral dual-wavelength…
- Conditions
- Impacted Mandibular Third Molar, Edema, Trismus, Postoperative Pain
- Trial name
- NCT07522918
- Testing
- Dual-wavelength GaAlAs laser (650+904 nm)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Atelectasis, Pulmonary Infection
Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
The effect of biphasic positive airway pressure (Bi-PAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo…
- Conditions
- Atelectasis, Pulmonary Infection, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Disease
- Trial name
- NCT03438383
- Testing
- Bi-PAP
- Volunteers
- 48 people
- Sponsor
- Evangelismos Hospital
Pain, Postoperative, Dental Pain
A Study of Acetaminophen for Post Surgical Dental Pain
To assess the safety, tolerability, analgesic, efficacy and pharmacokinetics of high dose acetaminophen relative to placebo and low dose acetaminophen relative to placebo over a 24 hour period in patient experiencing moderate to…
- Trial name
- NCT04018612
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Post-Operative Pain, Acute Pain
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of the study is to evaluate the efficacy, tolerability, safety and pharmacokinetics of Oxymorphone HCl as an analgesic for acute moderate to severe post-operative pain in pediatric subjects.
- Trial name
- NCT02687451
- Testing
- Oxymorphone HCl
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Post-Op Complication
Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery
This is an unblinded, single center, randomized study of infants with congenital heart disease undergoing cardiopulmonary bypass surgery, randomized to either the delayed rewarming intervention or to the standard of care (strict…
- Trial name
- NCT03036072
- Testing
- Strict normothermia, Delayed Rewarming
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Alexa Craig
Scoliosis Idiopathic, Pain, Postoperative
Virtual Reality After Pediatric Scoliosis Surgery
The purpose of this study is to evaluate the use of virtual reality after scoliosis surgery in pediatric patients.
- Trial name
- VRAS-PS (NCT04584970)
- Testing
- Applied VR, Apple iPad
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Respiratory Complications, Pediatric
Evaluation of Respiratory Acoustic Monitor in Children After Surgery
The study will evaluate the performance of measuring respiration rate with the Respiratory Acoustic Monitoring (RAM).
- Trial name
- NCT02256384
- Testing
- Respiratory Acoustic Monitor
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Adenotonsillectomy, Analgesia
Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity
The goal of this study is determine if an oral systemic course of steroids is a safe and effective option in lowering pain and complications following adenotonsillectomy in various pediatric age groups.
- Conditions
- Adenotonsillectomy, Analgesia, Surgery
- Trial name
- NCT04879823
- Testing
- Dexamethasone, Ibuprofen, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- David Chi, MD
Post Operative Pain
Effectiveness, Safety, and Tolerability Study of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of this study is to evaluate the effectiveness, tolerability, and safety of oxymorphone immediate release (IR) oral liquid as an analgesic for acute postoperative pain in pediatric subjects.
- Trial name
- NCT01210352
- Testing
- oxymorphone HCl
- Where
- 8 sites in United States
- Volunteers
- 61 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Moderate to Severe Acute Postoperative Pain
Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old
This is a multicenter, open-label (all people involved know the identity of the intervention), single dose trial to evaluate the pharmacokinetic (PK) profile (how drugs are absorbed in the body, how are they distributed within…
- Trial name
- NCT02221674
- Testing
- Tapentadol
- Where
- 7 sites in United States, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Grünenthal GmbH