Clinical trials: Posterior Urethral Valves
Chronic Kidney Diseases, Bladder Dysfunction
Concomitant Renal and Urinary Bladder Allograft Transplantation
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Conditions
- Chronic Kidney Diseases, Bladder Dysfunction, Bladder Absence, Posterior Urethral Valve
- Trial name
- NCT04626167
- Testing
- Concomitant Renal and Urinary Bladder Allograft Transplantation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Quality of Life, Posterior Urethral Valve
Study of the Quality of Life in School Aged-children With Posterior Urethral Valves
Posterior urethral valves (PUV) are the most common congenital obstructive lesion of the urethra, affecting from 1 per 3000 to 1 per 8000 live births.
- Conditions
- Quality of Life, Posterior Urethral Valve, Renal Insufficiency, Chronic Renal Disease
- Trial name
- QUALIVUP (NCT06439862)
- Testing
- Children with PUV
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Posterior Urethral Valve
Efficacy and Safety of Mirabegron Versus Oxybutynin After Posterior Urethral Valve Ablation
Posterior urethral valve is the main cause of bladder outlet obstruction in male infants and the most common cause of obstructive uropathy leading to chronic renal failure and end-stage renal disease in children.The incidence of…
- Trial name
- NCT07668232
- Testing
- Mirabegron
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- South Valley University
Posterior Urethral Valves
Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.
Boys with posterior urethral valves (PUV) are at increased risk of developing febrile urinary tract infections (fUTIs). As shown in the CIRCUP trial, circumcision plus antibiotic prophylaxis reduces the risk of FUTIs compared…
- Trial name
- CIRCUP 2 (NCT07527442)
- Testing
- Antibiotics strategy, Circumcision
- Where
- 13 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Posterior Urethral Valve
Outcomes of Posterior Urethral Valve Fulguration
To evaluate the long-term outcome after fulguration of the posterior urethral valve.
- Trial name
- NCT06867263
- Testing
- Fulguration
- Volunteers
- 35 people
- Sponsor
- Assiut University
Posterior Urethral Valve
Efficacy and Safety of Tamsulosin for Children with Posterior Urethral Valve.
To determine whether there is a role for Tamsulosin, A Selective Alpha-1 Adrenergic Blocker, as therapy in children with Posterior Urethral Valve post valve ablation , and whether there are side effects involved.
- Trial name
- NCT06737016
- Testing
- Tamsulosin, Oxybutynin, Trimethoprim/sulfamethoxazole (TMP/SMZ)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Posterior Urethral Valves
CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral Valves
Children with posterior urethral valves (PUV) are at risk of presenting febrile urinary tract infections (UTI). Circumcision has been shown to decrease the number of febrile UTIs in healthy children.
- Trial name
- CIRCUP (NCT01537601)
- Testing
- Circumcision, Antibiotic prophylaxis alone
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Posterior Urethral Valve
Overnight Bladder Drainage and Posterior Urethral Valve Sequelae
We hypothesize that overnight catheter drainage (OCD) of the urinary bladder might improve bladder dynamics and subsequently lead to improvement or resolution of hydronephrosis (HN) and renal function in boys who underwent PUV…
- Trial name
- NCT05168358
- Testing
- Overnight Bladder Drainage
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Mansoura University