Clinical trials: Postoperative Bleeding
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade.
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Blood Platelet Disorders, Blood Coagulation Disorders
- Trial name
- NCT00359398
- Testing
- Platelet rich plasma sequestration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Blood Loss, Surgical, Pediatric Heart Surgery
Effects of Intraoperative Blood and Blood Product Consumption on Postoperative Results in Pediatric Cardiac Surgery
Blood products and intravenous fluids are frequently used in the treatment of children who have undergone cardiac surgery in order to maintain hemodynamic stability.
- Trial name
- NCT03291769
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Cukurova University
Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children
Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy
The goal of this treatment study is to determine if doing lateral pharyngoplasty with tonsillectomy is better for children than doing tonsillectomy alone.
- Conditions
- Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children, Sleep Apnea, Obstructive, Tonsillitis
- Trial name
- NCT05575401
- Testing
- Lateral pharyngoplasty, Tonsillectomy
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- Loma Linda University
Spinal Epidural Hematoma
Establishment of Clinical Prediction Model for Postoperative Symptomatic Spinal Epidural Hematoma
The goal of this observational study is to establish a clinical prediction model based on artificial intelligence algorithms for patients with postoperative symptomatic spinal epidural hematoma(PSSEH) after spinal surgery.
- Trial name
- NCT06633848
- Testing
- spinal surgery
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Peking University Third Hospital
Chronic Tonsillitis
Study Comparing Harmonic Scalpel and Conventional Cold Steel Tonsil Removal Surgery in Children Requiring Tonsillectomy
This clinical trial aims to compare two commonly used methods of tonsil removal surgery (tonsillectomy) in children and adults with chronic tonsillitis.
- Trial name
- NCT07656831
- Testing
- Cold Steel Dissection Tonsillectomy, Harmonic Scalpel Tonsillectomy
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Allama Iqbal Teaching Hospital
Anxiety, Postoperative Pain
Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Tonsillectomy and Adenoidectomy
Dexmedetomidine is a drug known for its pain-relieving and restlessness-reducing effects. The purpose of this run is to use the association between this use during surgery and the attrition of post-operative pain and discomfort.
- Conditions
- Anxiety, Postoperative Pain, Bleeding
- Trial name
- NCT05986942
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Burak Omur
Pain Postoperative, Intraoperative Hemorrhage
Efficacy of Peritonsillar Dexmedetomidine Infiltration for Postadenotonsillectomy Pain
The purpose of the present study is the clinical assessment of the efficacy of preincisional peritonsillar infiltration of dexmedetomidine on postoperative pain relief in children undergoing adenotonsillectomy.
- Trial name
- NCT02013570
- Testing
- Dexmedetomidine
- Volunteers
- 71 people
- Sponsor
- TC Erciyes University
Postoperative Hemorrhage
Tranexamic Acid in Cyanotic Heart Defects
The use of antifibrinolytic agents such as to reduce blood loss in congenital cardiac surgery has been described in many studies
- Trial name
- NCT03244423
- Testing
- Normal saline at induction, Normal saline infusion, Intravenous tranexamic acid
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Anterior Shoulder Instability
Tranexamic Acid for the Latarjet Procedure.
The investigators propose a double-blinded randomized study evaluating the effectiveness of tranexamic acid in reducing postoperative swelling and haematoma formation after the Latarjet procedure.
- Trial name
- NCT03458468
- Testing
- Tranexamic Acid, Saline
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- Sports Surgery Clinic, Santry, Dublin
Pseudoaneurysm
Pseudoaneurysm of the Greater Palatine Artery Following Autogenous Connective Tissue Gingival Graft : A Case Series
Gingival recession is defined as the apical migration of the gingival margin from the amelocemental junction. This condition may be associated with symptoms such as tooth hypersensitivity, root decay, and cosmetic complaints from…
- Trial name
- NCT03454490
- Testing
- Postoperative pseudoaneurysm of the greater palatine artery
- Volunteers
- 10 people
- Sponsor
- Hopital de l'Enfant-Jesus
Osteoarthritis, Knee
Postoperative Drainage in Total Knee Arthroplasty in the Presence of Tranexamic Acid
The investigator's aim with this study is to address, with the new paradigm of tranexamic acid, the role of wound drainage following total knee arthroplasty in blood loss, blood transfusion requirements and functional recovery
- Trial name
- NCT03915756
- Testing
- Drainage of surgical wound
- Where
- Portugal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Congenital Fibrinogen Deficiency
Study to Assess the Efficacy, Safety and Pharmacokinetic of Octafibrin in Paediatric Subjects With Fibrinogen Deficiency
This study will assess the efficacy of Octafibrin, a fibrinogen concentrate in in the on-demand treatment of spontaneous or traumatic bleeding episodes in paediatric patients less than 12 years of age.The planned study duration…
- Trial name
- NCT02408484
- Testing
- Octafibrin
- Where
- 4 sites in India, Iran and 1 more
- Volunteers
- 15 people
- Sponsor
- Octapharma
Impacted Mandibular Third Molar
Comparison of Electrocautery and Scalpel Blade Incisions of Impacted Mandibular Third Molars
This randomized controlled trial aims to compare electrocautery and scalpel blade incisions during surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07723326
- Testing
- scalpel blade incision, electrocautery incision
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Riphah International University
Postoperative Hemorrhages
Prospective Registry on Vascular Access in Interventions in Lazio Region
Previous randomised studies showed that radial artery catheterisation for percutaneous cardiovascular procedures has a superior safety profile than femoral access, however the confirmation of these benefits in the real world by a…
- Trial name
- PREVAIL (NCT00674778)
- Testing
- Any percutaneous cardiovascular procedure
- Volunteers
- 1,052 people
- Sponsor
- San Filippo Neri General Hospital
Endoscopic Coblation Adenoidectomy
Coblation and Traditional Adenoidectomy: A Comparative Study
Adenoidectomy is a common pediatric otolaryngologic procedure. While cold curettage remains widely practiced, endoscopic coblation has been developed to enhance precision, minimize intraoperative complications, and reduce…
- Trial name
- NCT07417007
- Testing
- Cold Curettage Adenoidectomy, Coblation-Assisted Adenoidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Medipol University
Postoperative Hemorrhage
Antithrombin III Supplementation for Cardiopulmonary Bypass in Neonates
A prospective, randomized, placebo-controlled, double-blinded pilot study is planned. Neonates undergoing surgeries requiring cardiopulmonary bypass will receive antithrombin III (ATIII) supplementation or placebo in addition to…
- Trial name
- NCT01158729
- Testing
- Antithrombin (Recombinant)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Hemorrhage, Pain
Effect of Tonsillar Pillar Closure on Postoperative Pain and Bleeding Risk After Tonsillectomy
The purpose of this study is to determine if closing the tonsil fossa after tonsillectomy leads to less pain and bleeding risk than leaving it open to heal by secondary intention.
- Trial name
- NCT00394849
- Testing
- suture one tonsillar fossa
- Where
- United States
- Volunteers
- 763 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
Cardiac Surgery, Bone Wax, NU-KNIT, Median Sternotomy, Deep Sternal Wound Infection, Surgical Site Infection
Surgicel NU-KNIT Vs Bone Wax on Median Sternotomy
Bone wax is traditionally used as part of surgical procedures to prevent bleeding from exposed spongy bone. It is an effective hemostatic device which creates a physical barrier.
- Trial name
- NBCS (NCT06869772)
- Testing
- Closure of sternotomy
- Where
- Qatar
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Hemorrhage, Surgical, Tonsillar Bleeding
TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT06580509)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio