Clinical trials: Pre-eclampsia
Pulmonary Artery Doppler
Pulmonary Artery Doppler in Preeclamptic Mothers
Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia
- Trial name
- NCT06755073
- Testing
- Pulmonary artery Doppler ultrasound
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Preeclampsia
Peripartum Anesthetic Management of Patients With Preeclampsia
The investigators will conduct a prospective, observational multicentral international study of perioperative management of patients with preeclampsia.
- Trial name
- NCT05237011
- Where
- Israel
- Volunteers
- 1,500 people
- Sponsor
- Shaare Zedek Medical Center
Preeclampsia
Ibuprofen vs Dipyrone After C-section in Preeclampsia
The goal of this randomized, triple-masked clinical trial is to compare the effectiveness and safety of the use of ibuprofen versus dipyrone for postoperative analgesia in postpartum women with preeclampsia undergoing cesarean…
- Trial name
- DIPROFEN (NCT05586373)
- Testing
- medication 1, medication 2
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Preeclampsia, Eclampsia
The Preeclampsia Registry
The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy…
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Toxemia
- Trial name
- TPR (NCT06377878)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Preeclampsia Foundation
Preeclampsia
The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia
The goal of this clinical trial is to learn about in health conditions. The main questions it aims to answer are: The pathological significance of GPER in uterine artery dilation in preeclampsia The Mechanism of GPER Hippo…
- Trial name
- NCT06205771
- Testing
- H2S content
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hao Feng
Pre-Eclampsia
HMW-Adiponectin is Raised in Newborns
Cross sectional, hospital-based study dealing with adiponectin levels in newborns to mothers with pre-eclampsia. Venus cord blood samples were collected immediately after birth; 30 cases and 62 controls were enrolled into the…
- Trial name
- NCT00438542
- Sponsor
- University of Oslo
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia, Eclampsia
RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil
The perinatal morbidity and mortality rates for Brazil are five to ten-fold higher than those reported for upper income countries.
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Pregnancy
- Trial name
- NCT00097110
- Testing
- Vitamin C and E
- Where
- Brazil
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Posterior Reversible Encephalopathy Syndrome, Pregnancy Outcomes
The Clinical and Prognostic Features of PRES
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
- Conditions
- Posterior Reversible Encephalopathy Syndrome, Pregnancy Outcomes, Preeclampsia, Eclampsia
- Trial name
- NCT05143710
- Testing
- PRES in PE or E
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Dunjin Chen
Pre-Eclampsia; Complicating Pregnancy, Pre-eclampsia Aggravated
Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU
Severe pre-eclamptic toxemia has a high incidence of renal complications. Rapid diagnosis and termination of pregnancy are still the gold standard main treatment for pre-eclampsia.
- Trial name
- NCT05687669
- Testing
- Glyceryl trinitrate vs phentolamine for prophylaxis against renal impairment
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Assiut University
Placental Vascular Pathologies, Venous Thromboembolism Diseases
Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease
Venous thromboembolic (VTE) disease is the first cause of maternal mortality in the world. Some other pregnancy pathologies called Placental Vascular Pathologies (PVP) are linked to VTE by biological thrombophilia and are the…
- Trial name
- AngioPred (NCT00695942)
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Severe Preeclampsia
Risk Prediction Models for Adverse Maternal and Neonatal Outcomes in Preeclampsia
This proposal describes a single centre retrospective cross-sectional study which will address the need to further develop and test statistical risk prediction models for adverse maternal and neonatal outcomes in low-resource…
- Trial name
- NCT04058405
- Testing
- Observational
- Where
- Zimbabwe
- Volunteers
- 549 people
- Sponsor
- Mpilo Central Hospital
Birth Weight, Small for Gestational Age at Delivery
Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity
The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e.
- Conditions
- Birth Weight, Small for Gestational Age at Delivery, Large for Gestational Age at Delivery (Macrosomia), Diabetes, Gestational
- Trial name
- NCT05810545
- Testing
- Per- and polyfluoroalkyl substances (PFAS)
- Volunteers
- 256,659 people
- Sponsor
- Karolinska Institutet
Pre-eclampsia, Pregnancy
IMproved PRegnancy Outcome by Early Detection
The overall objective of the IMPROvED project is to develop a sensitive, specific, high-throughput and economically viable early pregnancy screening test for preeclampsia.
- Conditions
- Pre-eclampsia, Pregnancy, Pregnancy, High-risk, Pregnancy Complications
- Trial name
- IMPROvED (NCT01891240)
- Where
- 6 sites in Ireland, Netherlands and 2 more
- Volunteers
- 5,000 people
- Sponsor
- Louise Kenny
Preeclampsia
Antenatal Platelet Response on Aspirin: a Pharmacokinetic Study Through Pregnancy
Longitudinal pharmacokinetic and pharmacodynamic study in first and third trimester of pregnancy
- Trial name
- APROACH-PK (NCT04645004)
- Testing
- Aspirin 81Mg Non-enteric coated Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Pre-Eclampsia
Predictors of Intrauterine Growth Restriction
The main objectives of modern antenatal care programs are to identify high risk pregnancies then to predict any possibility of adverse pregnancy outcome as early as possible.
- Trial name
- NCT03349671
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Assiut University
Severe Preeclampsia
The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the…
- Trial name
- NCT07125599
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Pre-Eclampsia
CA-125 and Severity of Pre-Eclampsia
The Aim of this study is to determine the relationship between serum concentrations of cancer antigen-125 (CA-125) and pre-eclampsia severity.
- Trial name
- NCT02704676
- Testing
- marker(CA-125)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Autism Spectrum Disorder, Asthma
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)
FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social…
- Conditions
- Autism Spectrum Disorder, Asthma, Executive Dysfunction, Emotional Problem
- Trial name
- NCT03269110
- Testing
- SRS 2, CBCL, BRIEF-P
- Where
- 58 sites in Australia, Canada and 2 more
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Pre-Eclampsia
Indonesia Pravastatin to Prevent Preeclampsia Study
BACKGROUND Preeclampsia is a major cause of maternal and neonatal morbidity worldwide. There is currently no cure for preeclampsia, the only definitive treatment is termination of pregnancy by induction of labour or caesarean…
- Trial name
- INOVASIA (NCT03648970)
- Testing
- Pravastatin
- Where
- 7 sites in Indonesia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga