Clinical trials: Pre-eclampsia
Preeclampsia
Ibuprofen vs Dipyrone After C-section in Preeclampsia
The goal of this randomized, triple-masked clinical trial is to compare the effectiveness and safety of the use of ibuprofen versus dipyrone for postoperative analgesia in postpartum women with preeclampsia undergoing cesarean…
- Trial name
- DIPROFEN (NCT05586373)
- Testing
- medication 1, medication 2
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Cardiovascular Biomarkers, Preeclampsia (PE) Risk
A Study to Find and Confirm Blood-based Markers (Called Proteins) That May Show Early Heart Changes in Women With Preeclampsia, Even Before Symptoms Appear, and the Use of Heart Ultrasound (Echocardiography) to Look at Patterns of How the Heart Changes During Pregnancy in Women With Preeclampsia
The goal of this study is to find and confirm blood-based markers (called proteins) that may show early heart changes in women with preeclampsia, even before symptoms appear.
- Conditions
- Cardiovascular Biomarkers, Preeclampsia (PE) Risk, Preeclampsia (PE)
- Trial name
- PRECISE (NCT07463898)
- Testing
- No Intervention: Observational Cohort
- Where
- Nigeria
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Preeclampsia
Haptoglobin and Preeclampsia
The purpose of this study is to show that a certain protein called haptoglobin protects against preeclampsia which is a common pregnancy complication.
- Trial name
- NCT01027130
- Where
- Israel
- Sponsor
- Bnai Zion Medical Center
Preeclampsia
Fetal Renal Artery Doppler in Patients With Preeclampsia
Preeclampsia is a major devastating disorder affects 2:10% of pregnancies worldwide. preeclampsia may be associated with placental insufficiency which may cause fetal blood redistribution to essential organs like brain, heart…
- Trial name
- NCT06395974
- Testing
- fetal ultrasound
- Where
- Egypt
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Assiut University
Preeclampsia
Cornell University-Micronutrient Initiative Calcium Supplementation Study
The World Health Organization (WHO) now recommends prenatal calcium supplementation for prevention of preeclampsia in populations with inadequate dietary intake.
- Trial name
- MICA (NCT02238704)
- Testing
- Regimen A calcium and iron/folic acid, Regimen B calcium and iron/folic acid
- Where
- 16 sites in Kenya
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Cornell University
Pregnancy
PLAC1 in Reproduction
The PLAC1 gene is a recently described X-linked gene that maps to a region of the X chromosome thought to be important for normal fetal and placental development.
- Trial name
- NCT01277848
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Pre-Eclampsia, Volume Overload
PREDICTION OF FLUID RESPONSIVENESS WITH PASSIVE LEG RISING IN PREGNANT PATIENTS WITH SEVERE PREECLAMPSIA
BACKGROUND: A cornerstone of treatment in preeclampsia is to correct the potential hypovolemia with intravascular optimisation, which is usually performed as a fluid challenge.
- Conditions
- Pre-Eclampsia, Volume Overload, Hemodynamic Instability
- Trial name
- NCT03755843
- Testing
- PASSIVE LEG RISING
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- RAUL CARRILLO ESPER
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia Severe
Transorbital Ultrasound of Optic Nerve Sheath Diameter Between Healthy Pregnant Women and Those With Severe Preeclampsia.
The neurological alterations associated with preeclampsia depend on cerebral autoregulation, a theory that outlines the mechanisms by which the nervous system controls cerebral perfusion.
- Trial name
- NCT05594056
- Testing
- Transorbital ultrasound of the optic nerve sheet
- Where
- Panama
- Volunteers
- 100 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia, Pregnancy Related
Use of Lumella-glycosylated Fibronectin for Diagnosis of Preeclampsia
women with symptoms of preeclampsia from antenatal clinic or triage will be offered Lumella test along with traditional blood tests. If Lumella test is positive which will be compared with the traditional blood test results.
- Conditions
- Preeclampsia, Pregnancy Related, Hypertension
- Trial name
- Lumella (NCT06085001)
- Testing
- Lumella finger prick blood test
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Croydon University Hospital
Preeclampsia, Blood Pressure Check (Hypertension Screening)
EFFECT OF BLOOD PRESSURE MEASUREMENT IN DIFFERENT POSITIONS ON BLOOD PRESSURE VALUES AND ANXIETY LEVELS IN PREGNANT WOMEN WITH PREECLAMPSIA
Aim: This study examined the effects of blood pressure measurement in different positions on diastolic and systolic blood pressure values and anxiety levels in pregnant women diagnosed with preeclampsia.
- Trial name
- PREECLAMPSIA (NCT06898567)
- Testing
- Right Lateral Position, Left Lateral Position, Semi Fowler Position (45° Fowler)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Istanbul University - Cerrahpasa
Pre-Eclampsia
Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence
The reason for having a higher incidence of preeclampsia in primiparas may involve angiogenesis imbalance in these patients.
- Trial name
- NCT00262093
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Preeclampsia (PE) Risk, Oocyte Donation
Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR
The IMMUN-OR study aims to study HLA-C/KIR combinations when looking at the risk of development of preeclampsia (PE) in pregnancies after oocyte donation.
- Trial name
- IMMUN-OR (NCT07178652)
- Volunteers
- 2,325 people
- Sponsor
- Universitair Ziekenhuis Brussel
Preeclampsia, Hypertension
Study of Positive Airway Pressure in Preeclampsia to Reduce Blood Pressure
The purpose of this study is to identify whether sleep-disordered breathing - as measured by overnight polysomnography - is associated with pre-eclampsia and to determine whether use of positive airway pressure can improve…
- Trial name
- NCT01029691
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Michigan
Prenatal Care, Premature Birth
Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study
Preterm delivery, preeclampsia and intrauterine growth restriction are leading causes of perinatal morbidity and mortality. Efforts to treat these syndromes have not been effective, most likely becuase these obstetric…
- Trial name
- NCT00340899
- Where
- Chile
- Volunteers
- 19,134 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Severe Preeclampsia
Furosemide vs Placebo in Severe Preeclampsia Postpartum
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe…
- Trial name
- FUROPE (NCT07648251)
- Testing
- Furosemide, Folic Acid 5 MG
- Where
- Honduras
- Volunteers
- 186 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Premature Birth, Pre-Eclampsia
Select Nutrient and Gene Variant Analysis in a Targeted Diet and Lifestyle Intervention Reduces Preterm Birth
Preterm birth (PTB) rates in the US are among the highest in wealthy nations across the globe, and they are particularly high in our most socio-economically disadvantaged populations.
- Conditions
- Premature Birth, Pre-Eclampsia, Small for Gestational Age Infant
- Trial name
- SNGLI-PTB (NCT05436119)
- Testing
- GrowBaby
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- GrowBaby Life Project
Post Partum Severe Preeclampsia
Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia
There is no evidence that patients receiving magnesium sulfate before birth are required to maintain the drug for 24 hours. Therefore the investigators will have a randomized clinical study in patients with severe preeclampsia…
- Trial name
- MAG-PIP (NCT02307201)
- Testing
- Magnesium Sulfate
- Where
- 9 sites in Dominican Republic, Ecuador and 3 more
- Volunteers
- 1,114 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Toxemia
Predicting Complications in Women With Toxaemia
At present, the management of pre-eclampsia is guided by expert opinions that are not well-based on firm evidence. What is required is a clinical tool that can accurately determine a women's risk for adverse outcomes, and thereby…
- Trial name
- NCT00175526
- Testing
- preeclampsia
- Where
- 6 sites in Canada, New Zealand and 1 more
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypertension
Central Blood Pressure
The aim of the study is to check standard screening blood pressure in the arm and central blood pressure, the blood pressure at the heart in pregnant women.
- Trial name
- NCT03026010
- Testing
- central blood pressure
- Volunteers
- 100 people
- Sponsor
- St. Louis University