Clinical trials: Prebiotics
Premature Infants, Stool Bacterial Composition
Effects of Probiotic and Prebiotic Combinations on Premature Infants
The purpose of this study is to see how oral preparations containing both probiotics and prebiotics impact the growth, bacterial colonization of the intestines, and fecal short chain fatty acid content in premature infants.
- Conditions
- Premature Infants, Stool Bacterial Composition, Growth
- Trial name
- NCT00282113
- Testing
- ProBioPlus, Culturelle
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Stress Physiology
Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress
Emerging evidence supports the existence of a microbiota-gut-brain axis through which gut microbes influence cognition, mood and behavior.
- Trial name
- NCT05392556
- Testing
- Probiotic, Prebiotic
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Healthy Children
Study to Evaluate the Effects of a Formula on the Gut Health of Healthy Chinese Infants and Young Children
The infant gut microbiota, a major driver of the maturation of the immune system, is formed through the successive establishment and development during infancy and early childhood.
- Trial name
- NCT04864665
- Testing
- a formula with prebiotics and milk fat
- Where
- 6 sites in China
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Behavioral Measures of Tolerance
Nutritive Effects of Prebiotics on Early Postnatal Behavioral Measures of Tolerance
The study is intended to measure infant comfort, behavior, and sleep when consuming study formula with prebiotics compared to infants who consume a study formula without the prebiotics.
- Trial name
- NCT02118935
- Testing
- Previously marketed cow's mlik-based infant formula, Marketed cow's milk-based infant formula with prebiotics
- Where
- 7 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Healthy Infants
Study on the Effect of Inulin in Infant Formula on Gut Health
In this study the effect of Infant formula with added Inulin will be compared with the effect of Infant formula without Inulin on the Bifidobacterium level in stool.
- Trial name
- STAR-IFFO (NCT01515644)
- Testing
- Powder based infant formula
- Where
- Indonesia
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- PT. Sari Husada
Iron Absorption, Gut Microbiota
Iron Absorption From a Wheat-based Instant Cereal:Gut and Stable Isotope Studies in Kenyan Infants
The aim of this study is to measure the effect of a prebiotic (high dose/low dose) mixture at different doses within a wheat-based instant cereal, on fractional iron absorption (FIA), gut microbiota and inflammation after three…
- Trial name
- NCT03894358
- Testing
- FeFum and 7.5 g prebiotic mixture, FeFum and 3 g prebiotic mixture, Fefum and no prebiotic mixture
- Where
- Kenya
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy Term Babies
A Prebiotic Agave Derivated Metlin & Metlos in Infant Formula
Objectives: To evaluate the safety; efficacy; bone mineral metabolism \& immunity changes of the use of Metlin \& Metlos added to the Infant Formula Study Design: Randomized, double blind, clinical, controlled trial, in 600…
- Trial name
- NCT01251783
- Testing
- Infant Formula, Exclusively breast milk, Metlin+metlos+Lactobacillus GG
- Where
- Mexico
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Pediatrics, Mexico
Child Development, Diet, Healthy
Prebiotic Effects in Healthy Toddlers
The aim of this study is to demonstrate that a dietary supplementation with a novel prebiotic combination is safe, well tolerated and able to improve overall health of toddlers.
- Trial name
- PrebiKidz (NCT05783141)
- Testing
- New prebiotic follow-on formula, randomly assigned to healthy toddlers, Standard follow-on formula, randomly assigned to healthy toddlers
- Where
- Belgium
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Child Development
Soy Exposure on Bone Development and Gut Microbiota
In this project, the investigators aim to investigate the effects of soy consumption at early life on the development of gut microbiota and bone growth.
- Trial name
- NCT05213780
- Testing
- No intervention is involved
- Where
- Hong Kong
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Anemia, Iron-Deficiency
Iron Absorption From a Micronutrient Powder Containing Galacto-oligosaccharides (GOS)
Infants and young children in sub-Saharan Africa have high rates of iron deficiency anemia (IDA), which adversely affects their growth and cognitive development.
- Trial name
- FeGOS (NCT02666417)
- Testing
- Fortified maize porridge (MNP+iron), Fortified maize porridge (MNP+iron+GOS)
- Where
- Kenya
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Obesity
The Effect of the Oligofructose Supplementation on Body Weight in Overweight and Obese Children
This study is designed to assess the effect of oligofructose administration for 12 weeks on Body Mass Index (BMI) of overweight and obese children.
- Trial name
- NCT01673152
- Testing
- Oligofructose, Maltodextrin
- Where
- Poland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Weight Gain Trajectory, Metabolic Syndrome
Study of a Prebiotic Supplement to Mitigate Excessive Weight Gain Among Physicians in Residency
A randomized placebo controlled trial to determine if increased dietary fiber will prevent weight gain, inhibit adiposity and reduce perceived stress levels in residents at the Waco Family Health Center as the result of changes…
- Trial name
- NCT04498455
- Testing
- Prebiotin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Baylor University
Infectious Disease, Children, Only
Prebiotic Fructans on the Incidence of Acute Infectious Diseases in Children
The study aims to explore whether prophylactic dietary supplementation with prebiotic inulin-type fructans is able to influence the intestinal microbiota and the frequency of infectious disease episodes in kindergarten children…
- Conditions
- Infectious Disease, Children, Only, Diet Modification
- Trial name
- NCT03241355
- Testing
- prebiotic inulin-type fructan
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Microbial Colonization, Gut Microbiota
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children, one of the most vulnerable groups to the risk of diarrhea, with prebiotic fiber can improve their gut health.
- Trial name
- NCT06561724
- Testing
- Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Gastrointestinal Problems
Assessment of Efficacy and Tolerance of a Follow-On Milk Containing a Mixture of Prebiotics Fed to Young Children in Salvador, Bahia, Brazil
This clinical study will evaluate the effect on incidence of diarrhea, respiratory illness, stool patterns and growth of two cow's milk-based beverages for children.
- Trial name
- NCT01177605
- Testing
- Nutritional vanilla flavored beverage - 1) Milk-based beverage containing prebiotics 2) Milk-based beverage containing no prebiotics
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Autism Spectrum Disorder, Anxiety
Open-label Pilot Study Synbiotic Treatment for Autism Spectrum Disorder
The objective of this study is to conduct a open-label pilot study evaluating the feasibility, tolerability and preliminary efficacy of a 12-week course of synbiotic in improving anxiety symptoms in children with ASD.
- Trial name
- NCT06126185
- Testing
- 12-week course of synbiotic
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Metabolomics
The Effect of Feeding Infant Formula Containing Prebiotics and/or Probiotics
The study is intended to evaluate the microorganisms found in infant stools when consuming study formulas containing prebiotics and/or probiotics compared to infants consuming mother's own breast milk.
- Trial name
- NCT02948114
- Testing
- Control: Cow milk-based infant formula, Experimental 1: Cow milk-based infant formula, Experimental 2: Cow milk-based infant formula
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Focus on Healthy Infant Growth.
Infant Formula Supplemented With Probiotic Microorganisms and/or Prebiotic.
Evaluation the nutritional suitability of a based milk infant formula supplemented with friendly bacteria (probiotic microorganisms) and or nutritional fibers (prebiotic) to healthy, full term infants compare with an otherwise…
- Trial name
- NCT00836771
- Testing
- Infant Formula
- Where
- Israel
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Materna Laboratories
Infant Development, Healthy
Prebiotic EffecT InfanTs
The study aims to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on stool consistency in infants.
- Conditions
- Infant Development, Healthy, Diet, Healthy
- Trial name
- PETIT (NCT04791956)
- Testing
- Prebiotic
- Where
- 2 sites in Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Respiratory Tract Infections (RTI)
Impact of AHCC® Supplementation for Prevention of Respiratory Tract Infections Among Children Age 4-6 Years Old
This is a study to evaluate the effects of a prebiotic, AHCC, a standardized extract of cultured Lentinula edodes mycelia, on immunologic markers and the incidence of respiratory tract infections in children.
- Trial name
- NCT07479394
- Testing
- a prebiotic, that us a standardized extract of cultured Lentinula edodes mycelia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University