Clinical trials: Predictive Biomarkers
Hypoxic Ischaemic Encephalopathy (HIE), Asphyxia
BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
Despite recent advances in the care of mothers and newborn infants, many infants (approximately 20 per 1000 live births) continue to need resuscitation at birth.
- Trial name
- BiHiVE2 (NCT02019147)
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Cork
Atopic Dermatitis, Eczema
Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis
Atopic dermatitis (AD), also known as eczema, is the most common inflammatory skin disorder of children, affecting 10-20% of children and 1-2% of adults.
- Trial name
- NCT01782703
- Where
- 4 sites in United States
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Unilateral Cerebral Palsy
Validation of AI for Personalized Assessment and Rehabilitation of Upper Limb in Children With Unilateral Cerebral Palsy
Unilateral Cerebral palsy (UCP) is the most common neurological chronic disease in childhood with a significant burden on children, their families and health care system.
- Trial name
- AInCP (NCT06073522)
- Testing
- Artificial Intelligence for combining multi-domain data acquisition
- Where
- 2 sites in Italy, Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Severe Hypoglycemia, Type1diabetes
Longitudinal Study of the GLUcagon REsponse to Hypoglycemia in Children and Adolescents With New-onset Type 1 DIAbetes
The GLUREDIA study investigates the counter-regulatory response (CRR) during hypoglycemia in children with type 1 diabetes (T1D).
- Trial name
- GLUREDIA (NCT06770621)
- Testing
- Insulin-induced hypoglycemia test, Glucagon profile, Biological sample once
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Graft vs Host Disease
Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) can be hard to diagnose, difficult to manage and contributes significantly to morbidity and mortality in hematopoietic stem cell transplantation patients.
- Trial name
- ABLE-cGVHD (NCT02067832)
- Where
- 25 sites in United States, Austria and 1 more
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Acute Kidney Injury
Cystatin c: a Biomarker of AKI in Aneurysmal Subarachnoid Haemorrhage Patients
The goal of this observational study is to assess cystatin c as a predictive biomarker of early acute kidney injury in aneurysmal subarachnoid hemorrhage patients.
- Trial name
- NCT06635408
- Testing
- cystatin c
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Dental Implants, Submandibular Fossa Depth
The Gonial Angle as a Predictive Marker of Mandibular Fossa Depth
The aim of the study is to evaluate the relationship between submandibular fossa depth and gonial angle measurements in cone beam computed tomography examinations in terms of dental implant applications.
- Conditions
- Dental Implants, Submandibular Fossa Depth, Gonial Angle, Cone-beam Computed Tomography
- Trial name
- NCT04800003
- Testing
- Gonial angle and submandibular fossa depth measurements from CBCT images
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Ankara University
Chronic Obstructive Pulmonary Disease
Follow-up-study of COPD Patients and Healthy Controls for Evaluation of Predictive Non-coding RNA Biomarkers
Between 2012 and 2014, a cohort of 90 COPD subjects of disease severity grades GOLD I-IV as well as 60 healthy control subjects (30 smokers and 30 non-smokers) have been examined regarding different clinical and blood/ sputum…
- Trial name
- Ribo2 (NCT02522026)
- Where
- Germany
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Triple Negative Breast Cancer, HER2-positive Breast Cancer
Exosome as the Prognostic and Predictive Biomarker in EBC Patients
This study is the experimental study for serial ctDNA and exosome evaluation in EBC patients
- Trial name
- NCT05955521
- Testing
- exosome and ctDNA evaluation
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
PCOS (Polycystic Ovary Syndrome)
Development and Clinical Application of ApoC3 Protein as a Predictive Biomarker for Insulin Resistance in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the most common reproductive endocrine disorder causing infertility and miscarriage in women.
- Trial name
- NCT07739953
- Testing
- observational study
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Colorectal Cancer
Assessment of Glypican 3 as Apredictive Marker in Colorectal Cancer Patients
Evaluation Of Glypican 3 in serum of colorectal cancer patients . Correlation between Glypican 3 and clinicopathological characteristics of colorectal cancer .
- Trial name
- NCT04728139
- Testing
- glypican 3
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Disease
Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients
The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.
- Trial name
- NCT03899389
- Testing
- plasma samples collection
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport