Clinical trials: Pregnancy Trimester, First
Neurological Development After Exposition to an Antenatal Nuchal Translucency
Follow up of Neurologic Development of Children Who Presented at the First Trimester of Pregnancy an Isolated Nuchal Anomaly With Normal Karyotype
Prospective, multicenter study following for 2 years, 250 children who presented during the first trimester of pregnancy an isolated nuchal translucency over the 95th percentile of Nicolaïdes Curves on ultrasound and comparing…
- Trial name
- EDEN (NCT02223936)
- Testing
- group exposed, Control
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Undesired Intrauterine Pregnancy, First Trimester Pregnancy
Trial Comparing Intravenous and Oral Moderate Sedation for First Trimester Surgical Abortions
In the United States, the majority of first-trimester surgical abortions are performed in outpatient clinics that utilize a wide variety of oral and intravenous regimens for pain control.
- Trial name
- NCT01011634
- Testing
- Intravenous moderate sedation versus oral medication
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion Early
Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion
This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol
- Trial name
- MisoWet (NCT02522078)
- Testing
- dry misoprostol, wet misoprostol
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Iron Deficiency Anemia
Iron Metabolism Parameters At First Trimester and preGnancy outcomE
Iron deficiency anemia is the leading cause of anemia during pregnancy, which can still reach 10 to 20% of pregnant women in developed countries, with potentially serious consequences for the child.
- Trial name
- IMAGE (NCT03176147)
- Testing
- Iron deficiency anemia
- Where
- France
- Volunteers
- 865 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Miscarriage in First Trimester
Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes
The aim of this study is to establish clinically meaningful ultrasound-based diagnostic criteria for AP. To this end, the investigators will prospectively collect clinical and ultrasound data from early intrauterine pregnancies…
- Trial name
- NCT06262373
- Testing
- Ultrasound
- Where
- United Kingdom
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Abortion in First Trimester, Pain, Procedural
Ketamine Versus Fentanyl for Surgical Abortions
Ketamine is commonly used for procedural sedation and analgesia. It is widely used for trauma cases in the emergency department and is considered a superior agent in the outpatient setting due to its lack of respiratory and…
- Conditions
- Abortion in First Trimester, Pain, Procedural, Opioid Use
- Trial name
- NCT04871425
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Depressive Disorder
Bupropion & Cardio Birth Defect (Slone)
Bupropion is a unique drug that is used both to treat depression and as an aid in smoking cessation. In 2008, the final report from the Bupropion pregnancy registry described 24 congenital malformations among the 675 women…
- Trial name
- NCT01597661
- Testing
- Exposure to any bupropion during the first trimester, Exposure to bupropion alone during the first trimester, Referent group: no exposure to any anti-depressant or anti-smoking drug during pregnancy
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Pain Uterus
Intranasal Fentanyl for Pain Control During First-Trimester Uterine Aspiration
Intranasal fentanyl has been found to be safe and effective in the reduction of pain among pediatric and adult populations. The investigators hypothesize that patients who receive 100 mcg of intranasal fentanyl for pain control…
- Trial name
- NCT03057041
- Testing
- Fentanyl
- Where
- 2 sites in United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Screening for Hyperglycemia in First Trimester in High and Low Risk Pregnancy
Screening For First Trimester's Hyperglycemia in High and Low Risk Pregnancy
Glucose intolerance is the commonest medical disorder complicating pregnancy. Hyperglycemia increases the risk of delivering a large for gestational age newborn (LGA) and related complications such as operative delivery, birth…
- Trial name
- NCT06064552
- Testing
- blood sugar
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Preeclampsia, Intrauterine Growth Restriction
First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are clinical manifestations of placental insufficiency. These complications affect 5-15% of pregnancies, and are responsible for up to 20% of preterm births.
- Trial name
- NCT02879942
- Testing
- Ultrasound study of the placenta, Measurement of angiogenic and anti-angiogenic factors (sFlt-1 and PlGF) in the first trimestre blood test
- Where
- Spain
- Volunteers
- 1,390 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Incomplete Abortion, Intrauterine Contraception
Ideal Timing of Intrauterine Contraception Insertion After Medical Management of First Trimester Incomplete Abortion
Background: Unintended pregnancies continue to cause a public health threat in Low and Middle Income countries yet with restrictive abortion laws.
- Conditions
- Incomplete Abortion, Intrauterine Contraception, Misoprostol
- Trial name
- PAIC (NCT05343546)
- Testing
- Use of either copper T380A or Levonorgestrel LNG 52 IUS after medical management of first trimester incomplete abortion
- Where
- Uganda
- Volunteers
- 2,076 people
- Sponsor
- Makerere University
Migraine Disorders
Sumatriptan and Naratriptan Pregnancy Registry
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age.
- Trial name
- NCT01059604
- Testing
- Sumatriptan, Naratriptan, Sumatriptan-naproxen combination
- Volunteers
- 868 people
- Sponsor
- GlaxoSmithKline
Iron Deficiency
Pregnancy Outcome in Women With an Iron Deficiency in the First Trimester
The primary aim of this retrospective, monocentric study with two parallel groups is to investigate pregnancy outcome in women with iron deficiency in the first trimester.
- Trial name
- NCT05262634
- Testing
- Data collection (laboratory and obstetric results)
- Where
- Switzerland
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Medical; Abortion, Fetus
Comparison of Rate of Complete Abortion Between Letrozole Plus Misoprostol vs Misoprostol Alone
Comparison of rate of complete abortion between Letrozole plus Misoprostol versus Misoprostol alone in first trimester pregnancy
- Trial name
- NCT05940233
- Testing
- Letrozole
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Fetus Disorder
AutoFUSE or First-Trimester Ultrasound Scan
The goal of this clinical trial is to validate the clinical application capabilities of AutoFUSE. The main questions it aims to answer are: Does AutoFUSE reduce the time required to obtain standard planes in first-trimester…
- Trial name
- NCT07601191
- Testing
- AutoFUSE system, Traditional ultrasound scan
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Nuchal Translucency
What Happens to First Trimester Nuchal Translucency
First trimester nuchal translucency is a call point for genetic abnormalities and birth defects. Nuchal translucency varies with LCC and therefore with gestational age as described by Chung et al who created a 99th percentile…
- Trial name
- NCT04541966
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Montpellier
Contraception
IUD Insertion Post First Trimester Abortion
The goal of this study is to provide better information about contraception to women having an abortion so that they are less likely to have another unintended unwanted pregnancy.
- Trial name
- NCT01174225
- Testing
- Flexi T 380(+) IUD, Nova T IUD
- Where
- Canada
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pre-eclampsia, Intra-uterine Growth Restriction
Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers
The objective of this study is to test the efficacy of low-dose aspirin (160 mg/day), given bedtime and started early during pregnancy (≤ 15 +6 weeks of gestation) in nulliparous pregnant women selected as "high-risk" by the…
- Trial name
- PERASTUN (NCT01729468)
- Testing
- Aspirin
- Where
- 17 sites in France, Martinique
- Volunteers
- 1,106 people
- Sponsor
- University Hospital, Tours
Termination
Comparitive Study of Two Misoprostol Regimen in Early Pregnancy Termination
The aim of this study is to compare two misoprostol regimen in pregnancy termination.
- Trial name
- NCT01508143
- Testing
- Misoprostol 400 micrograms, Misoprostol 800 micrograms
- Where
- Iran
- Volunteers
- 41 people
- Sponsor
- Hormozgan University of Medical Sciences