Clinical trials: Premedication
Strabismus, Reflex, Oculocardiac
Hydroxyzine Dihydrochloride Premedication is a Necessity for Strabismus Surgery
Oculocardiac reflex (OCR) is usually happening in pediatric strabismus surgery and observed just when the surgent pulls the ocular muscles.
- Conditions
- Strabismus, Reflex, Oculocardiac, Hydroxyzine, Bradycardia Sinus
- Trial name
- NCT03806270
- Testing
- Midazolam, Hydroxyzine Dihydrochloride
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Yeditepe University
Pediatric Anesthesia, Preoperative Anxiety
Intranasal Dexmedetomidine vs Oral Midazolam for Premedication in Pediatric Surgery
This study aims to compare the effects of intranasal dexmedetomidine and oral midazolam as premedication in pediatric patients undergoing elective inguinal and urological surgery under general anesthesia.
- Conditions
- Pediatric Anesthesia, Preoperative Anxiety, Emergence Agitation
- Trial name
- NCT07565116
- Testing
- Dexmedetomidine, Midazolam
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Lactium, Premedication
Lactium Premedication to Prevent Emergence Agitation
This biased coin sequential allocation, dose finding study will be conducted to determine the effective dose of oral lactium in 90% of children (ED90) for prevention of emergence agitation during recovery from adenotonsillectomy.
- Conditions
- Lactium, Premedication, Emergence Agitation, Adenotonsillectomy
- Trial name
- NCT07894484
- Testing
- Lactium
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Separation Anxiety
Effects on Recovery of Children of Intravenous Formulation of Fentanyl Citrate and Midazolam Orally for Premedication
To study and compare the efficacy of intravenous formula of fentanyl citrate and midazolam administered orally for premedication in paediatric surgical patients.
- Trial name
- NCT05500599
- Testing
- Fentanyl Citrate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Asthma
Pharmacological Modulations of Allergen-Specific Immunotherapy
There is mounting evidence that successful allergen immunotherapy (SIT) functions through the induction of different subset of Treg including Foxp3 positive cells, therefore additional strategies to enhance this property are…
- Trial name
- NCT00504946
- Testing
- prednisone, lactose, prednisone, colecalciferol, lactose, lactose
- Where
- Poland
- Volunteers
- 85 people
- Sponsor
- Medical University of Lodz
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Tonsillitis, Tonsillectomy
Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy
The purpose of this pilot study: 1) to examine the use of gabapentin in reducing pain in the first 48 hours postoperatively including the total amount of narcotics mg/kg given 2) to record the time to first analgesic…
- Trial name
- NCT03625011
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Juvenile Idiopathic Arthritis
The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis
Far too many kids and families live in dread over the weekly nausea and vomiting caused by methotrexate - a medicine that controls joint swelling in Juvenile Arthritis patients.
- Trial name
- OPT-JIA (NCT04169828)
- Testing
- Methotrexate, Ondansetron, Folic/folinic acid
- Where
- 11 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University of British Columbia
Emergence Delirium
Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children
Study where children will receive one premedication, either intranasal dexmedetomidine or oral midazolam, to reduce agitation on emergence of anesthesia.
- Trial name
- NCT03171740
- Testing
- Dexmedetomidine, Midazolam oral solution, Oral saline
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Brasilia University Hospital
Anesthesia
The Premedication Properties of Oral Melatonin in Pediatrics Undergoing Therapeutic Cardiac Catheterization
The evaluation of oral melatonin efficacy as premedicant agent in pediatrics undergoing elective cardiac interventions is the primary outcomes of our trail.
- Trial name
- NCT06031961
- Testing
- melatonin
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Preoperative Anxiety
Effect of Premedication Type on Preoperative Anxiety in Children
Compare the effects of pharmacological and nonpharmacological premedications on preoperative anxiety and mask acceptance after adenotonsillectomy
- Trial name
- EPPA (NCT03530670)
- Testing
- oral midazolam, Film http://www.animaturk.com/animasyon/suko-ameliyat-oluyor., Playing smartphone game
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Dental Surgeries
Comparison of Nebulized Fentanyl, Midazolam and Dexmedetomidine as a Premedication in Pediatric Dental Surgeries
The preoperative time can be traumatic for young children undergoing surgery. Pediatric anesthesiologists act strongly to decrease distress for children in the operating room (OR) and to provide a smooth induction of anesthesia.
- Trial name
- NCT04226885
- Testing
- fentanyl, midazolam, dexmedetomidine
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Inhalational Anesthetics Adverse Reaction, Delirium on Emergence
Effects of Dexmedetomidine Premedication on Emergence Agitation After Strabismus Surgery in Children
Sevoflurane is frequently used for pediatric anesthesia because it has low pungency and rapid onset and offset of action.The reported incidence of emergence agitation (EA) following sevoflurane anesthesia varies from 10-80%.
- Conditions
- Inhalational Anesthetics Adverse Reaction, Delirium on Emergence, Strabismus Following Ocular Surgery
- Trial name
- NCT01895023
- Testing
- Dexmedetomidine, Midazolam, Saline
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Yao Yusheng
Preoperative Sedation
Intranasal Dexmedetomidine Premedication in Children
BACKGROUND INFORMATION AND RATIONALE Pediatric patients scheduled for dental procedures under general anesthesia can have significant anxiety before the procedure.
- Trial name
- NCT02250703
- Testing
- Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Mississippi Medical Center
Emergence Delirium, Anesthesia, Child
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
- Conditions
- Emergence Delirium, Anesthesia, Child, Anxiety, Midazolam Premedication
- Trial name
- NCT07336095
- Testing
- Melatonin group, Midazolam group, Control group
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, Local
Effectiveness of Buccal Infiltration During Vital Pulpotomy After Administering Two Analgesic Premedications
This Randomized study was designed to assess and compare the effect of two analgesic premedications (Ibuprofen BP 100 mg/5 ml and Paracetamol 200 mg/5ml.) on the anesthetic efficacy of buccal infiltration in vital pulpotomy of…
- Trial name
- NCT03423329
- Testing
- Brufen, Cital
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Emergence Delirium
Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.
An optimum recovery profile after AT includes a rapid, smooth awakening without emergence agitation (EA), stable vital signs and oxygenation, reduced postoperative nausea and vomiting (PONV), controlled postoperative pain, and…
- Trial name
- NCT06010927
- Testing
- ketamine/midazolam, Ketofol
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Anesthesia
Effect of Oral Dexmedetomidine, Ketamine, Or Midazolam as Preioperative Medications.
Anxiety preceding surgery results in hemodynamic instability, metabolic side effects, increased post-operative pain, and agitation during emergence.
- Trial name
- NCT05874245
- Testing
- oral Dexmedetomidine, oral ketamine, oral Midazolam
- Where
- Egypt
- Volunteers
- 222 people
- Sponsor
- Menoufia University
Preanesthetic Medication
The Use of ADV6209 for Premedication in Pediatric Anesthesia
To evaluate the effect of ADV6209, a new oral Midazolam formulation, on preoperative anxiety and sedation levels in paediatric anaesthesia Primary Objective: Sedation score (mYPAS) 30 min after administration of the premedication…
- Trial name
- NCT03931057
- Testing
- ADV6209 (=gamma-cyclodextrin-Midazolam), Midazolam
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Pediatric Anesthesia, Premedication
Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery
This prospective, three-arm study aims to evaluate the effects of different oral premedication regimens on venipuncture tolerance in pediatric patients undergoing ambulatory surgery.
- Trial name
- NCT07410078
- Testing
- Oral Midazolam Premedication, Oral Midazolam plus Ibuprofen Premedication, Oral Midazolam plus Ketamine Premedication
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital