Clinical trials: Premedication
Infant, Premature, Intubation, Intratracheal
Fentanyl and Rocuronium for Tracheal Intubation in Newborns
Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen…
- Conditions
- Infant, Premature, Intubation, Intratracheal, Respiratory Distress Syndrome, Newborn, Apnea of Prematurity
- Trial name
- NEORIN (NCT07650552)
- Testing
- Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- UEA - Universidade Do Estado Do Amazonas
Pediatric Anesthesia, Premedication
Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery
This prospective, three-arm study aims to evaluate the effects of different oral premedication regimens on venipuncture tolerance in pediatric patients undergoing ambulatory surgery.
- Trial name
- NCT07410078
- Testing
- Oral Midazolam Premedication, Oral Midazolam plus Ibuprofen Premedication, Oral Midazolam plus Ketamine Premedication
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Respiratory Distress Syndrome
Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)
The aim of the study is to compare the intubation conditions among propofol and remifentanil versus midazolam and remifentanil in premature neonates with respiratory distress syndrome.
- Trial name
- NCT00797160
- Testing
- propofol
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Minas Gerais
Autism Spectrum Disorder, Premedication
EMERGENCE AGITATION After Premedication IN PAEDIATRIC MAGNETIC RESONANCE IMAGING: A RETROSPECTIVE COHORT STUDY
The aim of this study was to assess the anxiolytic and sedative effect of OZALIN® / OZASED® (ADV6209) 0,25mg/Kg in children undergoing magnetic resonance imaging (MRI) under inhalational anesthesia.
- Conditions
- Autism Spectrum Disorder, Premedication, Brain Neoplasms, Brain Pathology
- Trial name
- premidazolam (NCT05946928)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parental/Caregiver Anxiety, Child's Anxiety
A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
The purpose of this investigator-initiated study is to compare the efficacy of oral midazolam and zolpidem for preoperative sedation, anxiety of patient, and caregiver anxiety at the time of separation, and ease of mask…
- Trial name
- PedsPreMed (NCT02096900)
- Testing
- zolpidem, Midazolam
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Loma Linda University
Emergence Delirium
Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.
An optimum recovery profile after AT includes a rapid, smooth awakening without emergence agitation (EA), stable vital signs and oxygenation, reduced postoperative nausea and vomiting (PONV), controlled postoperative pain, and…
- Trial name
- NCT06010927
- Testing
- ketamine/midazolam, Ketofol
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Anxiety
Interactive Tablet Compared to Oral Midazolam as Premedication in Preoperative Anxiety in Children
preoperative anxiety is an undesirable outcome in pediatric surgical patients.It can lead to behavioral trouble such as enuresis, apathy and sleep disorders.
- Trial name
- NCT04049201
- Testing
- elective surgery, Midazolam, Interactive Tablet
- Where
- Tunisia
- Volunteers
- 112 people
- Sponsor
- Hôpital d'enfants Béchir-Hamza
Premedication
Dexmedetomidine Premedication in Children
The aim of this retrospective study was to detect the effectiveness of 1µg/kg oral dexmedetomidine premedication on preoperative cooperation and emergence delirium of the the young children underwent complete dental treatment.
- Trial name
- NCT03174678
- Testing
- Dexmedetomidine, apple juice
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Anesthesia
The Comparison of Different Administration Routes of Pediatric Premedication
The study purpose is to compare the effect of different Administration Routes of Pediatric Premedication (including oral administration, intramuscular injection, rectal perfusion, intranasal).
- Trial name
- NCT02313337
- Testing
- Oral administration, Intramuscular injection, Rectal perfusion
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Adenotonsillectomy, Preoperative Anxiety
Timing Of Midazolam İn Children Undergoing Adenotonsillectomy: Effects On Stress, Cortisol, And Recovery
This study is a prospective, randomized, controlled clinical trial designed to evaluate the optimal timing of midazolam administration in children undergoing adenotonsillectomy.
- Conditions
- Adenotonsillectomy, Preoperative Anxiety, Surgical Stress Response, Postoperative Pain
- Trial name
- Timing-Midazol (NCT07622641)
- Testing
- Midazolam (Oral), Midazolam (Intravenous)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzurum City Hospital
Sedative; Anxiety Disorder
Intranasal Remimazolam for Premedication in Pediatric Patient
Anesthetic inhalation induction could be one of the most stressful experiences for children during the perioperative period, with almost 50% of them showing anxiety.
- Trial name
- NCT04720963
- Testing
- Remimazolam, Distilled water for injection, Dexmedetomidine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Respiratory Distress Syndrome, Newborn
Premedication for Less Invasive Surfactant Administration Study (PRELISA)
The purpose of this study is to conduct a double blinded randomized control trial to determine the safety and efficacy of using IV fentanyl and atropine prior to Less Invasive Surfactant Administration (LISA) procedure in preterm…
- Trial name
- PRELISA (NCT05065424)
- Testing
- IV Atropine and Fentanyl Premedication Arm
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Texas Southwestern Medical Center
Preoperative Sedation
Nebulized vs. Oral Midazolam Sedation in Pediatric Anesthesia: A Randomized Comparative Study
This study is to be carried out to compare nebulized and oral midazolam in achievement of a satisfactory level of sedation, Ramsey Sedation Score (RSS) of 4, within 30 mins of midazolam administration in pediatrics.
- Trial name
- NCT04760041
- Testing
- Midazolam nebulized, Midazolam oral solution
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Surgery
Premedication Gastric Ultrasound
The primary objective of this study is to assess gastric volume in fasted children using ultrasound before and after drinking premedication.
- Trial name
- NCT04130022
- Testing
- Point-of-Care Ultrasound
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kevin Spellman
Gastric Mucosal Lesion
Simethicone and N-acetylcysteine in Upper Endoscopy - Prospective Double-blinded Randomized Controlled Trial
The upper endoscopy is one of the most common methods for the diagnosis and treatment of upper gastrointestinal (GI) tract diseases and provides a unique opportunity to identify early neoplastic lesions.
- Trial name
- NCT02357303
- Testing
- Simethicone, Acetylcysteine
- Where
- Portugal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Separation, Family, Separation Anxiety
Use Of Midazolam In Premedication Of Pediatric Patients
: The aim of the study is to compare the effect of intranasal and oral midazolam administered for premedication to children of preschool age on hemodynamic parameters, sedation and separation from parents.
- Trial name
- NCT07021755
- Testing
- midazolam
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Preoperative Sedation
Intranasal Dexmedetomidine Premedication in Children
BACKGROUND INFORMATION AND RATIONALE Pediatric patients scheduled for dental procedures under general anesthesia can have significant anxiety before the procedure.
- Trial name
- NCT02250703
- Testing
- Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Mississippi Medical Center
Newborn, Preterm
Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation
The purpose of this study is to examine the influence of premedication drugs Atropin, Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac output in term and preterm newborn infants.
- Conditions
- Newborn, Preterm, Intubation
- Trial name
- NCT01427985
- Testing
- Atropine, Fentanyl, Mivacurium
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Ulm
Fever
Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion.
- Trial name
- NCT02430272
- Testing
- Glycopyrrolate
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Inje University