Clinical trials: Preterm
Preterm Birth, Early Intervention
Movement Imitation Therapy for Preterm Babies (MIT-PB) - A Pilot Study
Background: Very preterm babies are at high risk for developmental disorders. Prechtl's General Movements (GMs) Assessment is a valuable and reliable tool in infants until three months corrected age for predicting their further…
- Conditions
- Preterm Birth, Early Intervention, General Movements
- Trial name
- NCT07449312
- Testing
- Movement Imitation Therapy for Preterm Babies (MIT-PB), Usual care Physiotherapy
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Respiratory Distress Syndrome, Newborn
Aerosolized Surfactant in Neonatal RDS
Respiratory distress syndrome (RDS), caused by surfactant deficiency, is the leading cause of mortality and morbidity in preterm infants.
- Trial name
- AS-02 (NCT02294630)
- Testing
- Surfactant
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Sood, Beena G., MD, MS
Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome in Premature Infant
Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment - Validation Study
The aim is to re-validate a FTIR spectroscopy test for measuring lung maturity/Respiratory Distress Syndrome (RDS) before conducting a RCT using this test to guide surfactant treatment of preterm infants.
- Trial name
- FAST2 (NCT05615428)
- Testing
- LS-ratio
- Where
- 3 sites in Denmark
- Volunteers
- 68 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Failure
A Pilot Study of Synchronized and Non-invasive Ventilation ("NeuroPAP") in Preterm Newborns
There is currently a consensus that non-invasive ventilation (NIV) in preterm infants is preferred over intubation. There are two ways of delivering NIV in preterm infants, nasal continuous positive airway pressure (CPAP) or…
- Trial name
- NeuroPAP (NCT02480205)
- Testing
- NeuroBox to deliver the NeuroPAP
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Bronchopulmonary Dysplasia
Implementation of a Consensus-Based Discharge Protocol for Preterm Infants With Lung Disease
The researchers have worked to create consensus recommendations among national efforts to help with the transition and coordination of care for preterm infants with lung disease around discharge from the neonatal intensive care…
- Trial name
- NCT05285345
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Preterm Birth, Injuries
Nurse-Family Partnership Impact Evaluation in South Carolina
This study evaluates the effects of the Nurse Family Partnership (NFP), an established home-visiting program, using a scientifically rigorous individual-level randomized controlled trial.
- Conditions
- Preterm Birth, Injuries, Maternal Behavior
- Trial name
- NFP (NCT03360539)
- Testing
- Nurse-Family Partnership
- Where
- 9 sites in United States
- Volunteers
- 5,670 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Preterm, Iron Metabolism
Iron Metabolism in Small Pre Term Newborns
Iron is an essential micronutrient that plays an important role in cellular functions of all microorganisms. Both iron deficiency and iron excess during the early weeks of life can have severe effects on neurodevelopment that may…
- Conditions
- Preterm, Iron Metabolism, Iron Overload
- Trial name
- NCT01443195
- Testing
- Iron preparation
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Preterm Infant, Delivery Room
Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth
The aim of this prospective observational study (pilot study) is to test if synchronized noninvasive positive pressure ventilation (S-NIPPV) is feasible and works appropriately during transition from intrauterine to extrauterine…
- Conditions
- Preterm Infant, Delivery Room, Respiratory Support, Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)
- Trial name
- SenSyNoPP (NCT05399914)
- Testing
- S-NIPPV
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Preterm Neonate Analgesia
Melatonin As an Analgesic in Preterm Neonate
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms, antioxidant and anti-inflammatory effects, accumulating…
- Trial name
- NCT05971485
- Testing
- Melatonin 10 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Preterm Infant, Growth Acceleration
Effect on Early Somatic Growth of a Daily Kinesthetic Stimulation on Preterm Infants
Kangaroo position (KP), the essential component of the Kangaroo Mother Care (KMC) method, has been increasingly implemented, given the benefits of early skin-to-skin contact on the cerebral maturation of preterm infants.
- Conditions
- Preterm Infant, Growth Acceleration, Neurobehavioral Manifestations
- Trial name
- KISONKAP (NCT03574350)
- Testing
- KS in Kangaroo Position, KS in incubator
- Where
- Colombia
- Volunteers
- 66 people
- Sponsor
- Nathalie Charpak
Anti-infecting Agents, Local
Efficacy Study Comparing 2% Chlorhexidine in 70% Isopropyl Alcohol Versus 2% Aqueous Chlorhexidine
The purpose of this study is to compare the efficacy of two different antiseptic solutions (2%chlorhexidine in 70% alcohol with 2% aqueous chlorhexidine)when used in a standardized controlled manner in cleansing the skin of…
- Trial name
- NCT01270776
- Testing
- 2% aqueous chlorhexidine, 2% Chlorhexidine 70% isopropyl alcohol
- Where
- Canada
- Volunteers
- 462 people
- Sponsor
- Mount Sinai Hospital, Canada
Premature Neonate
Assessment of Ketamine and Propofol Sedation During LISA Method (Less Invasive Surfactant Administration)
Respiratory distress syndrome (RDS) caused by surfactant deficiency remains one of the major reasons of morbi-mortality in preterm infants and affects 85% of preterm babies born less than 32 week gestational age (wGA).
- Trial name
- ANALISA (NCT03705468)
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Montpellier
Bronchopulmonary Dysplasia
The Impact of Lung Recruitment Maneuver in 24-32 Weekers, and the Incidence of Bronchopulmonary Dysplasia
hypothesis : 1. The incident of dysplasia bronchopulmonary and/or death in 24-32 weekers babies on assist-control volume guarantee ventilation are lower in lung recruitment maneuver (LRM) group compare to control. 2.
- Trial name
- NCT04555889
- Testing
- lung recruitment maneuver (LRM) with DrageerVN500
- Volunteers
- 110 people
- Sponsor
- Dr. R. Adhi Teguh Perma Iskandar, Sp.A(K)
Trans Epidermal Water Loss
Effect of Twice Daily Application of Coconut Oil in Reducing Water Loss From Skin of Premature Babies in First Week of Life
The skin of newborn infants is immature and ineffective as a barrier. Preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness.
- Trial name
- TEWL (NCT01758068)
- Testing
- Coconut Oil Application
- Volunteers
- 74 people
- Sponsor
- Lady Hardinge Medical College
Child Development Disorders, Preterm Infant
Reliability of Hammersmith Examination in Prediction of Neurological Outcomes (REHAPENO)
In this study workers are trying to test the correlation between Hammersmith Infant Neurological Examination and MRI brain/cranial ultrasound with early prediction of neurological developmental outcome of preterm neonates.
- Conditions
- Child Development Disorders, Preterm Infant, Cerebral Palsy
- Trial name
- REHAPENO (NCT03580252)
- Testing
- Correlation analyses for the outcomes
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Abha International Private Hospital
Social Withdrawal of Childhood or Adolescence, Preterm Infant
The Effect of a Neonatologist's Standardized Guidance Intervention on Preterm Infants With Relational Withdrawal.
The objective of this project is to determine the effect of the verbal intervention on the decrease in sustained social withdrawal in late and moderately late preterm infants.
- Trial name
- NCT03212547
- Testing
- Verbal Intervention
- Where
- 2 sites in Chile
- Volunteers
- 110 people
- Sponsor
- Clinica Alemana de Santiago
Cholestasis, Psychomotor Disorders, Developmental
Preventing Cholestasis Using SMOFLipid®
Preterm infants of extreme low birth weight (ELBW, < 1000 gram birth weight) cannot immediately be nourished with mother´s or formula milk and are typically dependent on parenteral nutrition (PN) for a prolonged period of time.
- Trial name
- NCT01585935
- Testing
- SMOFLIPID, INTRALIPID
- Where
- Austria
- Volunteers
- 230 people
- Sponsor
- Medical University of Vienna
The Peak Oxygen Consumption (VO2max) Was Measured and Served as the Primary Endpoint of the Study
Influence of Prematurity and Its Respiratory Sequel on Exercise Testing in Childhood
Prospective study comparing hemodynamic and respiratory changes and exercise capacity during Cardio-Pulmonary-Exercise-Testing (CPET) in 4 groups of infants; Three different groups of premature infants and term controls
- Trial name
- NCT04833647
- Testing
- Cardio-Pulmonary-Exercise-Testing (CPET)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bronchopulmonary Dysplasia
Intratracheal Umbilical Cord-derived Mesenchymal Stem Cell for the Treatment of Bronchopulmonary Dysplasia (BPD)
Umbilical Cord-derived Mesenchymal stem cell has been proven effective in the experimental bronchopulmonary dysplasia (BPD).A multi-center study was designed to evaluate the safety and efficacy of the cellular therapy in…
- Trial name
- IUMTB (NCT03645525)
- Testing
- Human Umbilical Cord-derived Mesenchymal stem cell
- Where
- 3 sites in China
- Sponsor
- Children's Hospital of Fudan University
Bronchopulmonary Dysplasia
Pulmonary MRI of Ex-preterm Children With and Without BPD To Understand Risk of Emphysematous Changes
Health Issue: Bronchopulmonary dysplasia (BPD), a chronic lung disease, is the most common complication of being born premature. Damage to the still developing lung stops the normal formation of the alveoli.
- Trial name
- PICTURE (NCT02921308)
- Where
- 4 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Children's Hospital of Eastern Ontario
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