Clinical trials: Preterm
Preterm Infants
Single-Session Physiotherapy Versus Massage in Premature Infants
This study investigates the effects of a single-session physiotherapy intervention compared to massage in premature infants hospitalized in the neonatal intensive care unit.
- Trial name
- SPIM-Preterm (NCT07207161)
- Testing
- Infant Massage, Physiotherapy (Moyer-Mileur Protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Prematurity, Neonatal Encephalopathy
Evaluating the NeoTree in Malawi and Zimbabwe
Neonatal mortality remains unacceptably high. Globally, the majority of mothers now deliver in health facilities in low resource settings where quality of newborn care is poor.
- Conditions
- Prematurity, Neonatal Encephalopathy, Neonatal Sepsis, Neonatal Death
- Trial name
- NCT05127070
- Testing
- Neotree
- Where
- 5 sites in Malawi, Zimbabwe
- Volunteers
- 19,000 people
- Sponsor
- University College, London
Respiratory Syncytial Virus (RSV)
A Study to Assess the Safety and Effectiveness of Palivizumab Administered to Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus
This is a Phase 3b, prospective, multicenter, open-label, non-controlled study to assess the safety and effectiveness of immunoprophylaxis with the intramuscular (IM) administration of the liquid formulation of palivizumab for…
- Trial name
- Synagis Russia (NCT02968173)
- Testing
- Palivizumab
- Volunteers
- 50 people
- Sponsor
- AbbVie
Ventilator Lung; Newborn
Comparing Intubation Rates in the Delivery Room by Interface
Although the majority of premature neonates < 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined.
- Trial name
- NCT05609773
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Illinois College of Medicine at Peoria
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Respiratory Distress Syndrome (RDS), Neonatal Diseases and Abnormalities
Nasal High Frequency in Preterm Neonates
One of the most commonly used non-invasive methods is nasal continuous positive airway pressure (nCPAP). Although high frequency ventilation (HFV) has been applied in many neonatal intensive care units, nasal high frequency…
- Trial name
- NCT06687083
- Testing
- nasal high frequency oscillatory ventilation mode, nasal continuous positive pressure ventilation mode
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Invasive Mechanical Ventilation, Extubation
The External Diaphragm Pacemaker Assisted Extubation in Premature Infants With Invasive Mechanical Ventilation
With the development of perinatal medicine, more and more newborns with respiratory failure can be treated due to the use of respiratory support technology.
- Trial name
- NCT06404294
- Testing
- External Diaphragm Pacemaker treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Pulmonary Hypertension, Bronchopulmonary Dysplasia
The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia
Pulmonary hypertension may develop in premature newborn infants due to impaired lung development. The diagnosis of this disease can actually be made with interventional methods.
- Trial name
- NCT05082272
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Newborn Morbidity, Respiratory Failure
Comparing Two Different Modes of Ventilation in Pretem Neonates Bilevel VG and PRVC
Intubated preterm infants between 800-1200 grams and under 32 weeks of gestational age will start with PRVC ventilation mode, basal blood gases and work of breathing will measured.
- Conditions
- Newborn Morbidity, Respiratory Failure, Bronchopulmonary Dysplasia, Mechanical Ventilation Complication
- Trial name
- NCT04191239
- Testing
- GE ventilator with two different modes
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Skin Microbiome
Microbiome Survey of Preterm Infants
The skin and intestinal tracts of humans are covered with microbes, and the gene products of these microbes are collectively known as the human microbiome.
- Trial name
- NCT01942577
- Testing
- NoSting
- Where
- United States
- Sponsor
- Duke University
Pain
Randomised Trial of Eutectic Mixture of Local Anaesthetics Cream and Oral Sucrose Solution for Venepuncture
This randomized bicentric trial will investigate the efficacy of topical EMLA cream with oral sucrose solution compared to oral sucrose solution alone before venepuncture in preterm infants.
- Trial name
- VIEP (NCT00470080)
- Testing
- venepuncture
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth
Does Fetal Fibronectin and Ultrasound Cervical Length Help in the Evaluation of Women With Suspected Preterm Labor?
The objective of this study is to investigate the effect of the use of both sonographic cervical length (CL) and fetal fibronectin (FFN) on the length of outpatient triage and preterm labor interventions in symptomatic women with…
- Trial name
- NCT00371046
- Testing
- Transvaginal ultrasound cervical length, Cervicovaginal fetal fibronectin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Patent Ductus Arteriosus in Premature Infants
Chest Shielding in Premature Infants During Phototherapy
This is a feasibility study where Infants will be randomized to either chest shielding with aluminum foil or chest shielding without aluminum foil while undergoing phototherapy for premature infants.
- Trial name
- SLIGHT (NCT02552927)
- Testing
- Chest shield with aluminum foil (CALF), SHIELD
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Premature Delivery
Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island
Prematurity is the leading cause of mortality and perinatal morbidity. Despite the many preventive measures and use of tocolytic therapy, the incidence of premature births has not decreased in recent decades.
- Trial name
- PARTOSURE-OI (NCT02904070)
- Testing
- Vaginal swabbing
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Prematurity
Preterm Neonates Brain Ultrasound With CEUS and Elastography
The aim of the study is to investigate levels of brain perfusion and elasticity in preterm neonates when they reach the estimated due date and to compare the data with magnetic resonance imaging at term.
- Trial name
- NCT05694611
- Testing
- Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride
- Where
- Finland
- Sponsor
- Turku University Hospital
Motor Skills Disorders, Premature Birth
Premie DCD Imaging Intervention Study
This study will leverage a current longitudinal study of brain development in preterm children. In the Miller/Grunau Trajectories study, preterm children are returning for follow-up at 8-9 years.
- Trial name
- NCT04483401
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Parenteral Nutrition, Necrotizing Enterocolitis
Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children
Manganese (Mn) is an essential metal required for normal growth and development. However, exposure to high Mn levels can be toxic to the brain.
- Conditions
- Parenteral Nutrition, Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392730
- Testing
- Remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Preterm Prelabor Rupture of Membranes, PPROM
Extended Azithromycin Treatment in Prelabor Rupture of Membranes
The purpose of this study is to learn whether adding extra doses of azithromycin to the standard antibiotic treatment for preterm prelabor rupture of membranes may improve pregnancy outcomes for patients between 22 weeks and 28…
- Trial name
- NCT07669207
- Testing
- Azithromycin (Azithro), Standard Azithromycin Dosing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexa Henderson
Mid Trimester Cervical Shortening
A Randomized Trial of Cerclage Versus 17 α-Hydroxyprogesterone Caproate for Treatment of a Short Cervix
We hypothesized that weekly intramuscular injections of 17 hydroxyprogesterone caproate(17P) will reduce the number spontaneous preterm births prior to 35 weeks gestation when compared to cerclage therapy.
- Trial name
- NCT00694967
- Testing
- McDonald cerclage placement, 17 hydroxyprogesterone caproate
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Lehigh Valley Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.