Clinical trials: Preterm Infant Health
Early Interventions, Preterm Infants
Effects of Early Behavioral and Transaction Interventions on Preterm Infants' and Parents' Biopsychosocial Well-being
This randomized controlled trial will use a longitudinal repeated-measures design to examine the effects of two interventions, behavioral support interventions and a parent-infant transactional program, on parents' stress, PPD…
- Conditions
- Early Interventions, Preterm Infants, Parent-Child Relations
- Trial name
- NCT03013023
- Testing
- BS, Routine care, PITP
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Parental Infant Bonding, Cardio-respiratory Stability in Preterm NICU Infants
Effects of Reading to Preterm Infants on Baby and Parents' Well Being
Reading to children is believed to be beneficial to cognitive and mental development.This study will examine the response of premature Neonatal Intensive Care Unit (NICU) infants to bedside reading by measuring changes in heart…
- Trial name
- NCT02518997
- Testing
- Parental Reading Aloud
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Georgetown University
Premature Infant, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial)
This study is being done to see if outcomes for both a premature infant's parents and the infant born prematurely who have spent time in the neonatal intensive care unit (NICU) can be improved through parent cognitive behavioral…
- Conditions
- Premature Infant, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Development, Child, Parent-Child Relations
- Trial name
- PreVNT (NCT03906435)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Metabolic Bone Disease, Osteopenia
A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic Method
The goal of this project is to develop a new noninvasive ultrasound based technique, called vibro-acoustic analysis (VAA), for evaluation of infant bone health with particular application in assessment of bone health in premature…
- Conditions
- Metabolic Bone Disease, Osteopenia, Neonatal Rickets
- Trial name
- NCT04752098
- Testing
- Vibro-acoustic analysis (VAA), based on ultrasound radiation force
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Mayo Clinic
Prenatal Care
Group Antenatal Care: The Power of Peers for Increasing Skilled Birth Attendance in Achham, Nepal
In rural Nepal, the major drivers of underutilization of skilled birth attendance are poverty, poor social support and inadequate birth planning.
- Trial name
- NCT02330887
- Testing
- Group Antenatal Care, Individual Antenatal Care
- Where
- Nepal
- Volunteers
- 2,184 people, healthy volunteers welcome
- Sponsor
- Possible
Premature Birth
Follow-Up of VLBW Infants With Chronic Lung Disease: Respiratory Health and Neurodevelopment
Although previous studies showed that preterm infants resolving from neonatal respiratory disease are more likely to exhibit respiratory illness, developmental disorders, impaired growth and cognitive limitations compared with…
- Trial name
- NCT00358891
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- National Taiwan University Hospital
Behavioral Assessment of Children, Early Intervention
PaREnting ProgrAm to Enhance PREterm Infants' Health and Development (PREPARE Trial)
Preterm infants are at high risk of developmental delay or disabilities and they do benefit from early intervention programs. Many programs aiming at improving preterm infants' developmental outcome have been proposed with mixed…
- Trial name
- PREPARE (NCT04783220)
- Testing
- Comprehensive structured parent intervention
- Where
- Lebanon
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Premature Birth
Feeding and Transition to Home for Preterms at Social Risk
Premature infants are at high risk of suboptimal health and development. This randomized clinical trial evaluated the impact of a developmentally based intervention, H-HOPE (Hospital-home transition: optimizing prematures'…
- Trial name
- H-HOPE (NCT02041923)
- Testing
- H-HOPE, Attention Control
- Where
- 2 sites in United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Wheezing
A Phase 3 Trial of the Effect of Motavizumab Prophylaxis on Reduction of Serious Early Childhood Wheezing in Infants
The primary objective of this study is to assess the efficacy of motavizumab compared to placebo when administered monthly to preterm infants during their first RSV season for the reduction of the incidence of serious early…
- Trial name
- NCT00628303
- Testing
- Motavizumab
- Volunteers
- healthy volunteers welcome
- Sponsor
- MedImmune LLC
Music Therapy
The Effects of Recorded Receptive Music Therapy on Oral Nutrition and the Well-being of the Italian Premature Baby
The investigators have thought with a dedicated research group, to deepen the use of receptive music therapy so that it can improve the non-nutritive sucking of premature babies through listening to lullabies sung by parents and…
- Trial name
- NCT04759170
- Testing
- Music therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Preterm Infant Health, Preterm Infant Development
Preterm Infants: Light Effects on Health and Development
Preterm babies cared for in the intensive care nursery are exposed to amounts of light that are very different from the exposures to an unborn baby or the newborn term baby.
- Trial name
- NCT02146287
- Testing
- Cycled Light
- Volunteers
- 121 people
- Sponsor
- Duke University
Preterm Birth
E-health-supported Diagnostic and Intervention in Preterm Born Children and Their Families
The app-based diagnostic and support approach with a focus on mental and somatic symptoms is intended to strengthen the resilience of premature born children and families and to identify risk and resilience factors.The overall…
- Trial name
- NeoUp2 (NCT06939192)
- Testing
- Intervention Group (APP), Treatment as usual-Group (TAU)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Premature Birth, Respiratory Disease
Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants
Approximately 8% of all births occur between 30-36 weeks of gestation ('moderate-late' prematurity). Respiratory tract infections (RTI) and wheezing illnesses disproportionally affect preterm infants resulting in a 1.5-2 fold…
- Conditions
- Premature Birth, Respiratory Disease, Respiratory Tract Infections, Preterm Birth
- Trial name
- LONG LOVE (NCT05618769)
- Testing
- LONG LOVE Framework
- Where
- Netherlands
- Volunteers
- 330 people
- Sponsor
- Franciscus Gasthuis
Preterm Birth
Interdisciplinary E-health Based Follow-up of Preterm Born Children
The aim of the study is to assess mental and somatic symptoms of preterm born children at the ages of 2, 5 and 10 by a multidisciplinary team and to evaluate an app that screens for these symptoms.
- Trial name
- NeoUp (NCT06345664)
- Testing
- Diagnostics and intervention recommendations
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Neonates or Premature Babies, Parent
Impact of Implementing Reach Out and Read in the Neonatal Intensive Care Unit
This is a pre/post quasi-interventional study with two arms. First, a baseline cohort of parent-infant dyads admitted to the Neonatal Intensive Care Unit (NICU) were enrolled and surveyed at three timepoints (admission…
- Conditions
- Neonates or Premature Babies, Parent, Reading, NICU Infants
- Trial name
- NCT07511075
- Testing
- Shared reading program
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Catherine Caruso
Pregnancy Complications, Preterm Labor
Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda
The purpose of this study is to determine whether a combination of evidence-based strategies can improve intrapartum and newborn care in facilities to reduce mortality among preterm infants.
- Conditions
- Pregnancy Complications, Preterm Labor, PreTerm Birth, Stillbirth
- Trial name
- PTBi-KE-UG (NCT03112018)
- Testing
- data strengthening, modified Safe childbirth checklist - control, modified Safe childbirth checklist - enhanced
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 102,988 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Premature Infant, Premature Babies
Intervention for Neurodevelopmental Support in Preterm Infants Using Responsive Parenting and E-health
Research problem and specific questions More than 1000 very preterm infants (\< 32 weeks) are born every year in Sweden.
- Trial name
- INSPIRE (NCT06688695)
- Testing
- Neurodevelopmental support
- Where
- 7 sites in Sweden
- Volunteers
- 176 people
- Sponsor
- Umeå University
Infection, Enterocolitis, Necrotizing
Oropharyngeal Administration of Mother's Colostrum for Premature Infants (NS-72393-360)
Extremely premature (BW<1250g) infants are at high risk for morbidity and mortality. Own mother's colostrum (OMC) and milk (OMM) protect against neonatal morbidity and are rich in immune factors which may provide…
- Conditions
- Infection, Enterocolitis, Necrotizing, Ventilator-associated Pneumonia
- Trial name
- NCT02116699
- Testing
- oropharyngeal mother's milk, oropharyngeal sterile water
- Where
- 5 sites in United States
- Volunteers
- 260 people
- Sponsor
- Endeavor Health
Premature Birth
A Cluster Randomized Controlled Trial of FICare At 18 Months
In Alberta, one in every twelve babies is born preterm. Compared with their full term counterparts, preterm infants who survive are at higher risk for respiratory problems, jaundice, infections, feeding problems, behavioural…
- Trial name
- NCT03337659
- Testing
- Family Integrated Care
- Where
- Canada
- Volunteers
- 297 people
- Sponsor
- University of Calgary