Clinical trials: Prevention & Control
Cystic Fibrosis, Prediabetes
Prevention of Cystic Fibrosis Diabetes
Acute systemic hyperglycemia causes oxidative stress and a pro-inflammatory response. The pro-inflammatory cytokines induced by hyperglycemia are toxic to islet insulin producing cells, and thus worsen glucose intolerance.
- Trial name
- Prevent (NCT00967798)
- Testing
- Sitagliptin
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Neonates Needing Resuscitation at Birth
Personal Protective Equipment for the Prevention of SARS-Cov-2 During Neonatal Resuscitation
There has been an increasing number of SARS-CoV-2 infections in pregnant women and neonates. Interventions including open airway suctioning, positive pressure ventilation, non-invasive respiratory support, tracheal intubation…
- Trial name
- NCT04666233
- Testing
- Neonatal resuscitation with PPE for the prevention of SARS-Cov-2 infection, Neonatal resuscitation without PPE for the prevention of SARS-Cov-2 infection
- Where
- 2 sites in Italy
- Volunteers
- 48 people
- Sponsor
- University Hospital Padova
Dental Caries
Radiographic Progression of Infiltrated Caries Lesions In-vivo
This study is investigating the efficacy of caries lesion infiltration therapy as compared to the current preventative approach for early caries lesions.
- Trial name
- ICON (NCT01496456)
- Testing
- Resin infiltration, Caries management
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Michigan
Infant, Low Birth Weight, Anemia
Erythropoietin Treatment in Extremely Low Birth Weight Infants
Objective: To investigate whether recombinant EPO reduces the need for transfusion in extremely low birth weight (ELBW) infants and to determine the optimal time for treatment.
- Trial name
- EPO (NCT00593801)
- Testing
- epoetin beta
- Where
- Germany
- Volunteers
- 219 people
- Sponsor
- Charite University, Berlin, Germany
Anemia During Pregnancy
The Effect Of Pumpkin Seed Extract Capsules On Nutritional Status and Haemoglobin Level in Pregnant Women.
The goal of this to measure the effect of supplementation of Yellow Pumpkin Seed Extract Capsules in pregnant women on hemoglobin levels and nutritional status of pregnant women.
- Trial name
- NCT05657821
- Testing
- Pumpkin seeds extract capsules
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Rosdiana Syakur
Overweight and Obesity, Eating Disorders
Project Health: Enhancing Effectiveness of an Obesity Prevention Program
This 2-site effectiveness trial will test whether a brief dissonance-based obesity prevention program delivered in single sex groups combined with food response and attention training will produce significantly larger weight gain…
- Trial name
- NCT06067763
- Testing
- Project Health, Response and Attention Training, The Weight of the Nation
- Where
- 2 sites in United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Appendicitis
A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.
A large retrospective study compared wound irrigation with antiseptic solution, with antimicrobial agent, and with normal saline in patients undergoing open appendectomy and concluded an evident superiority of antibiotic wound…
- Trial name
- NCT04332809
- Testing
- saline-gentamicin irrigation, saline irrigation
- Where
- Egypt
- Volunteers
- 208 people
- Sponsor
- Mansoura University
CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection
Neonatal Catheter Lock for Infection Prevention
For newborns admitted to Neonatal Intensive Care Units (NICUs), one of the main risk factors for late-onset sepsis is the presence of a central venous catheter (CVC), which is often essential for the administration of medications…
- Conditions
- CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection, Neonatal Sepsis, Late-Onset
- Trial name
- Neo-CLIP (NCT07585188)
- Testing
- Taurolidine 2% lock, Normal saline lock
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- University of Turin, Italy
Necrotizing Enterocolitis
IBP-9414 for the Prevention of Necrotizing Enterocolitis
Two different dose levels will be evaluated in two different birth weight categories, compared to placebo with regards to safety and tolerability.
- Trial name
- NCT02472769
- Testing
- IBP-9414
- Where
- 15 sites in United States
- Volunteers
- 120 people
- Sponsor
- Infant Bacterial Therapeutics
Respiratory Tract Infections, Influenza
Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu)
Purpose: The study null hypothesis is that vitamin D supplementation will not influence time to acute respiratory tract infection in sheltered accommodation residents.
- Trial name
- ViDiFlu (NCT01069874)
- Testing
- Cholecalciferol (Vitamin D/Vigantol oil), Miglyol oil
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Anxiety, Depression
Applying the Spanish Version of the UP-A as a Universal School-based Anxiety and Depression Prevention Program
The current study proposes to extend transdiagnostic treatment research to adolescents by establishing initial pre to post-treatment and follow-up outcomes associated with the use of the Spanish Version of the Unified Protocol…
- Trial name
- NCT03123991
- Testing
- UP-A adapted as a preventive intervention, Same than experimental group (EG), after EG finishes
- Volunteers
- 157 people
- Sponsor
- Universidad Nacional de Educación a Distancia
Allergic Conjunctivitis
Evaluation of Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens in the Treatment of Allergic Conjunctivitis
The purpose of this study is to evaluate the efficacy and safety of an anti-allergy drug with a contact lens compared to placebo in preventing ocular itching associated with allergic conjunctivitis
- Trial name
- NCT00445874
- Testing
- Ketotifen with a Contact Lens (no generic name)
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Vistakon Pharmaceuticals
Child Behavior, Sedentary Behavior
Strengthening Child Social-Emotional and Lifestyle Health in Families Experiencing Stress
This study evaluates feasibility and preliminary efficacy of a parent-based prevention program to promote social-emotional and lifestyle behavior health among 3- to 9-year-old children in families experiencing major stressors.
- Conditions
- Child Behavior, Sedentary Behavior, Self-regulation, Parenting
- Trial name
- NCT06163703
- Testing
- Family Life Skills Triple P
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Bullying of Child, Child Behavior Disorders
Prevention Workshop to Address Bullying Behaviors in Schools
This study, titled APACHES, is a cluster randomized controlled trial aimed at evaluating the effectiveness of a school-based prevention program, "Tous Épanouis à l'École" (TEAL), conducted by healthcare students as part of their…
- Conditions
- Bullying of Child, Child Behavior Disorders, Social Behavior, Mental Health
- Trial name
- APACHES (NCT06835205)
- Testing
- Tous Épanouis à l'École (TEAL Program), Standard Health Education Sessions
- Where
- France
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Nosocomial Infection, Diarrhea
L Reuteri for the Prevention of Nosocomial Diarrhea
Nosocomial diarrhea is any diarrhea that a patient contracts in a health-care institution. In children, it is commonly caused by enteric pathogens, especially rotavirus.
- Conditions
- Nosocomial Infection, Diarrhea, Gastroenteritis
- Trial name
- PND (NCT01046656)
- Testing
- Lactobacillus reuteri (DSM 17938)
- Where
- Poland
- Volunteers
- 106 people
- Sponsor
- Medical University of Warsaw
Mental Health, Aggressive Childhood Behavior
Mental Health Prevention Among Preschool Children Effectiveness Study
Mental health in Chilean children and families is an urgent public health problem. Prevalence of psychiatric disorders among children between 4 and 11 years old is 27.8%, a higher percentage than was found in adolescents between…
- Conditions
- Mental Health, Aggressive Childhood Behavior, Problem Behavior, Social Behavior
- Trial name
- ICPS Chile (NCT03683056)
- Testing
- I Can Problem Solve (ICPS) Program
- Where
- Chile
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Fundación San Carlos de Maipo
Pneumothorax
Intrapleural Minocycline After Aspiration of Spontaneous Pneumothorax
The estimated recurrence rate of primary spontaneous pneumothorax is 23-50% after the first episode, and the optimal treatment remains unknown.
- Trial name
- NCT00839553
- Testing
- Intrapleural Minocycline application
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Acute Kidney Injury, Renal Tubulopathy
Prevention of Cisplatin-induced Nephrotoxicity
The research design is a prospective, randomized, controlled clinical trial in children to study effect of aminophylline in preserving renal function in oncologic patient received cisplatin either combined with other CMT or used…
- Trial name
- NCT06196853
- Testing
- Aminophylline
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Surgical Site Infection, Surgical Wound Infection
ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions
ROSSINI 2 is a phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor), multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of several in-theatre…
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Surgery--Complications, Surgery
- Trial name
- ROSSINI 2 (NCT03838575)
- Testing
- 2% alcoholic chlorhexidine skin prep (SKIN PREP), Iodophor Antimicrobial Incise Drapes (DRAPE), Gentamicin-impregnated implants/ sponges (SPONGE)
- Where
- 2 sites in United Kingdom
- Volunteers
- 6,610 people
- Sponsor
- University of Birmingham
Dental Caries
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
The objective of this study is to assess the safety and to evaluate the anti-caries efficacy of COL101 (arginine) non-fluoride dentifrices compared to a 0.24% sodium fluoride dentifrice in 10-14 year-old children over a one year…
- Trial name
- NCT04750902
- Testing
- 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 2,025 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
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