Clinical trials: Prevention & Control
Migraine Disorders, Headache Disorders
Therapy for Migraine Prevention in Children 6-11 Years of Age
The aim of this study is to evaluate the effect of SPN-538 for the prophylaxis of migraine in pediatric patients 6 to 11 years old.
- Trial name
- NCT04050293
- Testing
- SPN-538
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Tuberculosis, Pulmonary
Digital Health Intervention to Improve TPT Uptake
Despite the evidence of the prevention and control measures of tuberculosis (TB), it still has an impact on the health, social, and economic aspects of the population.
- Trial name
- DHiTPT (NCT07313995)
- Testing
- Digital health intervention
- Where
- 14 sites in Ethiopia
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Arba Minch University
Central Line Bloodstream Infections
The Effectiveness of Silver Alginate (Algidex) Patch in the Prevention of Central Line Infections in Very Low Birth Weight Infants
The purpose of this study is to determine whether silver alginate (Algidex) patch is effective in the prevention of central line infections in very low birth weight infants.
- Trial name
- NCT00964093
- Testing
- Silver Alginate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Post Traumatic Stress Disorder
Cognitive-Behavioural Therapy as a Preventive Treatment for Post Traumatic Stress Disorder
This study will examine the use of modified prolonged exposure therapy in trauma patients recently exposed to trauma in an emergency room to prevent the onset of post-traumatic stress disorder.
- Trial name
- NCT03116165
- Testing
- Modified prolonged exposure therapy, Attention control
- Where
- Sweden
- Volunteers
- 352 people
- Sponsor
- Karolinska Institutet
Ventricular Septal Defect, Atrioventricular Septal Defect
A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects.
- Conditions
- Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
- Trial name
- NCT05253209
- Testing
- L-citrulline, Plasmalyte A
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Landing Biomechanics, Jumping Performance
Effectiveness of Core Training on the Biomechanics of Jump Landing in Amateur Female Basketball Players
The goal of this clinical trial is to evaluate the effectiveness of a core training intervention on jump-landing biomechanics in female amateur basketball players.
- Conditions
- Landing Biomechanics, Jumping Performance, Trunk Stability
- Trial name
- NCT06633237
- Testing
- Core training program in female amateur basketball players
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Depression
Vortioxetine to Prevent Return of Symptoms in Children With Depression
The purpose of this study is to find out if vortioxetine is better than placebo (sugar pills) in preventing depression in children who improved when treated with vortioxetine.
- Trial name
- NCT05014919
- Testing
- Vortioxetine
- Where
- 17 sites in United States, Colombia and 5 more
- Volunteers
- 35 people
- Sponsor
- H. Lundbeck A/S
HIV, Sexually Transmitted Infections
Randomized Control Trial of Family-Based HIV Prevention for Latinos
The proposed project will test an HIV prevention intervention for Latino parent-adolescents dyads. This randomized controlled trial will: 1.
- Trial name
- LatinoSTYLE (NCT01635335)
- Testing
- Latino STYLE
- Where
- United States
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Myopia, Mental Health
A Study of the Impact of Digital Intervention on Parents/primary Caregivers' Myopia Prevention and Control Health Literacy on Preschoolers' Myopia and Physical and Mental Health
The study is a Randomized controlled trial based on digital interventions, involving pre-school children and their parents or major caregivers.
- Conditions
- Myopia, Mental Health, Obesity
- Trial name
- NCT06620250
- Testing
- Digital Prevention and control of myopia
- Volunteers
- 882 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
Research Objective: Primary outcome -To compare efficacy Intrauterine vs Sublingual MISOPROSTOL in addition to Oxytocin in reducing blood loss of post-cesarean section in high risk women Secondary outcome -To study…
- Trial name
- NCT04560218
- Testing
- sublingual Misoprostol, Intrauterine Misoprostol
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Dental Caries
Comparative Evaluation of Hydrophilic and Hydrophobic Sealants in Partially Erupted First Molars
This randomized controlled clinical trial aims to evaluate and compare the retention, caries prevention, microleakage, and fluoride release of three types of pit and fissure sealants-hydrophilic, nanofilled hydrophobic, and…
- Trial name
- NCT07052526
- Testing
- Prevention, Prevention of caries, Prevention therapy
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Accidental Falls
Trial to Reduce Falls Incidence Rate in Frail Elderly
Background: Approximately 750,000 elderly Dutch people fall at least once a year, which often results in physical injuries and a fear of falling, with high costs and far-reaching consequences on functionality, physical activity…
- Trial name
- CP (NCT00512655)
- Testing
- Fall prevention course
- Where
- 3 sites in Netherlands
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Respiratory Distress Syndrome, Newborn, Premature Birth
SURFAXIN® Treatment for Prevention of Bronchopulmonary Dysplasia (BPD) in Very Low Birth Weight (VLBW) Infants.
SURFAXIN® (lucinactant) treatment will be examined in very low birth weight infants to prevent development of chronic lung disease, commonly known as bronchopulmonary dysplasia (BPD), in premature infants who have required…
- Conditions
- Respiratory Distress Syndrome, Newborn, Premature Birth, Bronchopulmonary Dysplasia
- Trial name
- NCT00215540
- Testing
- Lucinactant 175 mg/kg, Lucinactant 90 mg/kg
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Windtree Therapeutics
Autism Spectrum Disorder, Obesity
Mobile Health Intervention for Children With Autism
This study is a randomized clinical trial conducted in China from January 2023 to July 2025. It aims to test whether a mobile health program delivered via WeChat, with or without additional human support, can help improve body…
- Conditions
- Autism Spectrum Disorder, Obesity, Pediatric Overweight
- Trial name
- WeChat-Autism (NCT07514910)
- Testing
- Standard Lifestyle Recommendations, WeChat-Based Mobile Health Intervention, Coach-Facilitated Tele-Group Sessions
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Hunan Normal University
Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder
Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
A subgroup of patients with childhood-onset obsessive-compulsive disorder (OCD) and/or tic disorders has been identified who share a common clinical course characterized by dramatic onset and symptom exacerbations following group…
- Conditions
- Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder, Streptococcal Infection, Tic Disorder
- Trial name
- NCT00001359
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
HIV/AIDS and Infections, Sexually Transmitted Diseases
Puerto Rico Cuidalos Parent-adolescent Program
Latino adolescents are at high risk for HIV/AIDS, other sexually transmitted infections (STIs), and unintended pregnancies. Puerto Rican adolescents, in particular, experience disparities in these areas, yet few adolescent and…
- Conditions
- HIV/AIDS and Infections, Sexually Transmitted Diseases, Pregnancy Prevention
- Trial name
- NCT03063385
- Testing
- Parental Communication intervention, Health promotion control condition
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Infections
Reducing HIV in Adolescents
The purpose of this study is to assess the impact of a cash-incentivised prevention intervention on reducing HIV incidence rates in high-school learners in rural KwaZulu-Natal.
- Trial name
- RHIVA (NCT01187979)
- Testing
- Cash incentives, Life skills curriculum
- Where
- South Africa
- Volunteers
- 3,217 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
Intellectual Disability, Mild to Moderate, Sexual Abuse
Behavioural Skills Training (BST) for Teaching Sexual Abuse Prevention Skills for Children With Intellectual Disabilities
The main goal of the study was to see if Behavioural Skills Training (BST) could improve knowledge about sexual abuse and the ability to resist it among children with intellectual disabilities.
- Trial name
- BST (NCT06732479)
- Testing
- Behavioural Skill Training Programme
- Volunteers
- 120 people
- Sponsor
- University of Canberra
Chemotherapy-induced Nausea and Vomiting
Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)
The purpose of this study was to determine the appropriate dosing regimen of fosaprepitant, when administered with ondansetron (with or without dexamethasone), for the prevention of CINV in children from birth to <17 years of…
- Trial name
- NCT01697579
- Testing
- Fosaprepitant, Ondansetron, 5-hydroxytryptamine 3 antagonist
- Volunteers
- 240 people
- Sponsor
- Merck Sharp & Dohme LLC
Domestic Violence, Mental Health Impairment
Trial of a Multi-pronged Intervention to Address Prevention of Violence in Zambia
This study evaluates the effectiveness of a multi-pronged intervention in reducing and preventing violence against women and children compared to a treatment as usual control group among families living in Lusaka, Zambia.
- Conditions
- Domestic Violence, Mental Health Impairment, Child Abuse, Alcoholism
- Trial name
- NCT02790827
- Testing
- CETA, Treatment as usual
- Where
- Zambia
- Volunteers
- 626 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
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