Clinical trials: Prevention of Pregnancy
Preterm Delivery
Prevention of Preterm Delivery in Twin Pregnancies by 17 Alpha-hydroxyprogesterone Caproate
Preterm birth remains a major cause of perinatal morbidity and mortality in developing as well as in developed countries. Despite major clinical research efforts aimed at reducing the incidence of preterm births in the United…
- Trial name
- NCT00141908
- Testing
- 17-alpha Hydroxyprogesterone Caproate, Castor oil
- Where
- Lebanon
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Very Preterm Infants (<32 Weeks of Gestation)
Administration of Extracellular Vesicles From Donor Human Milk in Preterm Infants
The AdVEMPrem study is exploring whether tiny particles called extracellular vesicles (EVs), which are naturally found in human milk, can help protect very premature babies from serious gut problems such as necrotizing…
- Trial name
- AdVEMPrem (NCT07402083)
- Testing
- Donor human milk extracellular vesicles (DHM-EVs)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Urinary Tract Infections
Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a Previous Urinary Tract Infection
Our hypothesis is that long-term antimicrobial prophylaxis does not reduce the recurrence of infection and the risk of appearance of kidney scars in children with a documented previous upper UTI.
- Trial name
- NCT00156546
- Testing
- antibiotic to reduce the recurrence of infection
- Where
- 16 sites in Italy
- Volunteers
- 660 people
- Sponsor
- University of Padova
HIV Infections, Sexually Transmitted Diseases
MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania
The MEMA kwa Vijana Project is a community randomised trial which aims to assess the impact of a targeted intervention on adolescent sexual and reproductive health in Mwanza Region, Tanzania.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Pregnancy, Sexual Behavior
- Trial name
- NCT00248469
- Testing
- In-school Sexual Health Education, Youth-friendly health services, Youth condom promotion & distribution
- Where
- Tanzania
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hepatitis B, Vertical Transmission of Infectious Disease
The COMBAT HBV Feasibility Trial
This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC).
- Trial name
- COMBAT-HBV (NCT05705427)
- Testing
- Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 317 people
- Sponsor
- University of North Carolina, Chapel Hill
Cancer
Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation
RATIONALE: Antivirals such as valacyclovir act against viruses and may be effective in preventing cytomegalovirus. It is not yet known if valacyclovir is effective in preventing cytomegalovirus in patients undergoing stem cell…
- Trial name
- NCT00045292
- Testing
- acyclovir, acyclovir sodium, valacyclovir
- Where
- 6 sites in United States
- Sponsor
- Fred Hutchinson Cancer Center
Kidney Diseases, Urologic Diseases
Folic Acid for Prevention of Contrast Induced Nephropathy
The purpose of this study is to determine whether periprocedural administration of folic acid is effective in the prevention of contrast induced nephropathy in patients undergoing coronary CTA/angiography/angioplasty.
- Trial name
- FAPCIN (NCT02444013)
- Testing
- Folic acid
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Teen Pregnancy Prevention
Evaluation of Are You Ready?
The goal of this randomized trial is to learn if the Are You Ready? (AYR) intervention has a positive impact on the sexual and mental health behaviors of sexually active youth between the ages of 14 and 22 years old who are at…
- Trial name
- AYR (NCT06580080)
- Testing
- Are You Ready? (AYR), Social Media Awareness Shorts (SMAS)
- Where
- United States
- Volunteers
- 1,850 people, healthy volunteers welcome
- Sponsor
- The Policy & Research Group
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer
RATIONALE: Pyridoxine (vitamin B6) may prevent or lessen hand-foot syndrome caused by chemotherapy. It is not yet known whether pyridoxine is more effective than a placebo in preventing hand-foot syndrome.
- Conditions
- Breast Cancer, Drug/Agent Toxicity by Tissue/Organ, Endometrial Cancer, Fallopian Tube Cancer
- Trial name
- NCT00245050
- Testing
- pyridoxine hydrochloride, doxorubicin HCL liposome
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Case Comprehensive Cancer Center
Malaria, Sexually Transmitted Diseases
Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth
The purpose of this study is to examine whether treatment of pregnant Malawian women with repeated doses of sulfadoxine-pyrimethamine and azithromycin antibiotics will prevent preterm deliveries and result in other health…
- Conditions
- Malaria, Sexually Transmitted Diseases, Preterm Birth, Pregnancy
- Trial name
- NCT00131235
- Testing
- Sulfadoxine-pyrimethamine treatment twice during pregnancy, Sulfadoxine-pyrimethamine at 4-week intervals, Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice
- Where
- Malawi
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Tampere University
Epithelial Ovarian Cancer
Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of Therapy in Women Undergoing Staging and Intraperitoneal Chemotherapy for Advanced Ovarian Cancer
The purpose of this research is to determine if a film to prevent adhesions will improve the area of distribution of a contrast dye (representative of chemotherapy) in the abdominal cavity (belly) of women who have undergone…
- Trial name
- NCT01095367
- Testing
- Seprafilm™
- Where
- 2 sites in United States, Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Sexual Behavior
Replication of Evidence-based Programs
The purpose of this school-level randomized intervention trial is to evaluate the It's Your Game…Keep It Real program, an evidence-based teen pregnancy, HIV, and STI prevention program, among 2,000 students from 20 middle schools…
- Trial name
- NCT03533192
- Testing
- It's Your Game...Keep it Real
- Volunteers
- 2,588 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Teen Pregnancy
Evaluation of a Need to Know (N2K): A New Sex Education Program for High School Students
This trial evaluated the impact of N2K, a three-year quasi-experimental study to delay sexual initiation and increase condom and contraception use among high school students.
- Trial name
- N2K (NCT02539602)
- Testing
- The Need to Know students received the N2K curriculum as described previously
- Volunteers
- 1,616 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Nephrotic Syndrome
Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome
Idiopathic nephrotic syndrome is generally responsive to steroid therapy, but some patients need other immunosuppressants to reduce steroid dependency.
- Trial name
- NCT01895894
- Testing
- Mycophenolate mofetil
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Neurogenic Bladder, Catheter-Related Infections
Antiseptic-coated Intermittent Urinary Catheter
Study design is a prospective, randomised, double-blind, and interventional. Primary aim of the study is to investigate efficacy of antiseptic-coated intermittent hydrophilic urinary catheters in prevention and reduction of…
- Trial name
- GuardianCath (NCT02697162)
- Testing
- Antiseptic-coated catheter, Hydrophilic catheter, Octenidine chloride
- Where
- Croatia
- Sponsor
- Children's Hospital Zagreb
Preterm Birth, Obstetric Labor, Premature
Prevention of Preterm Labor in Patients With a Previous Episode of Threatened Preterm Labor With Progesterone
The purpose of this study is to determine if the use of 250 mg of intramuscular progesterone biweekly can reduce the incidence of preterm labor in patients with an episode of threatened preterm labor during the current pregnancy.
- Trial name
- NCT01317225
- Testing
- 17 α hydroxyprogesterone caproate
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
HIV Infections, Pregnancy
A Study of Nevirapine to Prevent HIV Transmission From Mothers to Their Infants
The purpose of this study is to see if giving the anti-HIV drug nevirapine (NVP) to HIV-positive pregnant women and their infants can help reduce the chance that a mother will give HIV to her baby during delivery.
- Trial name
- NCT00001135
- Testing
- Nevirapine
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 2,009 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnancy in Adolescence
Evaluation of the Positive Prevention PLUS Program
This study aims to determine if the Positive Prevention PLUS teen pregnancy prevention program has an impact on abstinence, birth control use, and likelihood of becoming pregnant.
- Trial name
- PP+ (NCT02540278)
- Testing
- Positive Prevention PLUS
- Where
- United States
- Volunteers
- 4,267 people, healthy volunteers welcome
- Sponsor
- California State University, San Bernardino
Preterm Birth, Pregnancy
Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)
Women pregnant with twins or triplets are at high risk of preterm birth, yet no intervention or approach has served to reduce this risk.
- Conditions
- Preterm Birth, Pregnancy, Multifetal
- Trial name
- NCT00099164
- Testing
- 17 alpha-hydroxyprogesterone caproate (17P)
- Where
- 14 sites in United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Respiratory Syncytial Virus Infection, Premature Birth
Palivizumab for Prevention of Severe Respiratory Syncytial Virus Infection in Russian Children
100 Russian children of 2 years of age and less in high-risk populations (preterm, and/or with heart and lung problems) will receive palivizumab (Synagis) 15 mg/kg intramuscularly as prophylaxis to severe respiratory syncytial…
- Conditions
- Respiratory Syncytial Virus Infection, Premature Birth, Bronchopulmonary Dysplasia, Congenital Heart Disease
- Trial name
- NCT01006629
- Testing
- palivizumab
- Where
- 19 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Abbott