Clinical trials: Primary Headache Disorders
Migraine Disorders
A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents
Migraine is a neurological disease characterized by severe and recurrent headaches. Children and adolescents with migraine often present to the emergency department (ED) with acute attacks, where migraine accounts for up to ~30%…
- Trial name
- NCT05102591
- Testing
- Ketorolac, Metoclopramide, Active Remote Electrical Neuromodulation Device
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Migraine
Zonisamide Versus Topiramate in Migraine
Investigators aim to compare the effect of zonisamide versus topiramate in migraine by assessing the absolute reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days…
- Trial name
- NCT06347497
- Testing
- Zonisamide 50 MG, Topiramate 50 MG
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Kafrelsheikh University
Migraine Disorders
Special Drug Use Investigation for AMERGE® Tablet (Long-term)
To investigate the long-term safety and efficacy of AMERGE (naratriptan hydrochloride) on Japanese patients with migraine headache in clinical setting
- Trial name
- NCT01332383
- Testing
- Naratriptan
- Volunteers
- 300 people
- Sponsor
- GlaxoSmithKline
Migraine, Tension Type Headache
The Efficacy of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Working Community
This study is a controlled, cluster randomised, interventional trial to evaluate the effectiveness of a workplace cognitive and physical program (Intervention), in reducing the frequency of head and neck pain in an extensive…
- Conditions
- Migraine, Tension Type Headache, Cervical Pain
- Trial name
- NCT00551980
- Testing
- Cognitive, Relaxation, Exercise Therapy
- Where
- Italy
- Volunteers
- 2,895 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Children, Only, Headache, Migraine
The Prognosis of Migraine and Tension-Type Headache in Children and Adolescents
Children and adolescents that visited the pediatric neurology clinic at the Bnai Zion medical center do to migraine or TTH headache between the years 2007-2010 were reevaluated.
- Conditions
- Children, Only, Headache, Migraine, Headache, Tension
- Trial name
- NCT04623203
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Bnai Zion Medical Center
Migraine, Patent Foramen Ovale
Patent Foramen Ovale Closure in Migraine
The goal of this observational study is to retrospectively observe the effect of PFO closure and medication on migraine. The main questions it aims to answer are: Whether PFO closure is more effective in the treatment of migraine…
- Trial name
- NCT06192173
- Testing
- Percutaneous PFO closure
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Haiyan Wang
Colic, Infantile, Migraine
Infants Colics : Towards a Migrainous Origin ?
According to recent studies, we want to find evidences that infant colics could be a episodic symptom associated to migraine as cyclic vomiting syndrome or abdominal migraine are.
- Conditions
- Colic, Infantile, Migraine, Migraine Equivalents
- Trial name
- COLIGRAINE (NCT03155360)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Migraine, Endometriosis
Endometriosis and Migraine
This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls.
- Trial name
- EMC (NCT06785129)
- Testing
- Thermal stimuli, Pressure stimuli, Pain ratings
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Migraine
A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine
The purpose of this study is to learn about the effect of a study medicine called rimegepant in adolescents who have frequent migraine attacks. Rimegepant is a tablet that disintegrates when you put it on or under your tongue.
- Trial name
- NCT06616194
- Testing
- Rimegepant
- Where
- 102 sites in United States, Canada and 10 more
- Volunteers
- 636 people
- Sponsor
- Pfizer
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Migraine Headaches
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Trial name
- NCT04211454
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Migraine, Tension-Type Headache
Carotid Sinus Massage in Trendelenburg Position for Headache Relief
Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types.
- Trial name
- NCT06745648
- Testing
- Arm A - Carotid Sinus Massage + Trendelenburg (CSM+T)
- Where
- Argentina
- Volunteers
- 18 people
- Sponsor
- Hospital Municipal Pedro T. Orellana
Tension-Type Headache, Unspecified, Intractable
Tension-Type Headache Gene Expression and Methylation
Tension-type headache (TTH) refers to pain radiating from the forehead to the back of the head as a bilateral band. It often occurs without warning and spreads to the neck muscles.
- Trial name
- TTH (NCT06562855)
- Testing
- Peripheral blood sampling
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- University of Gaziantep
Migraine
Nerivio Efficacy Under High-Frequency Use
This is a Post-marketing study investigating the impact of frequant usage with Nerivio on the safety profile of Remote Electrical Neuromodulation (REN) for the treatment of migraine.
- Trial name
- NCT07336056
- Testing
- Nerivio (REN device)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Theranica
Migraine Disorders, Obesity
A Pilot Study of Migraine and Appetite Behaviour in Children
The purpose of this study is to determine whether there is an association between migraine in children and certain patterns of appetite or eating behaviour that may lead to later obesity.
- Trial name
- NCT00930852
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Cyclic Vomiting Syndrome, Abdominal Migraine
Auricular Neurostimulation for Cyclic Vomiting Syndrome
This study evaluates the efficacy of auricular neurostimulation via an non-invasive percutaneous electrical nerve field stimulator in children and adults with cyclic vomiting syndrome.
- Trial name
- NCT03434652
- Testing
- Percutaneous neurostimulation
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Medical College of Wisconsin
Migraine, Near Death Experience
Near Death Experience (NDE) and Migraine
Migraine is a common disabling primary headache disorder. Epidemiological studies have documented its high prevalence and high socio-economic and personal impacts. Migraine affects more than 20% of the French population.
- Trial name
- NCT02854930
- Testing
- questioning
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Migraine Disorders
Drug Use Investigation for AMERGE (Naratriptan Hydrochloride) Tablet
The study is designed to investigate the information on safety and efficacy of naratriptan tablets on Japanese subjects with migraine headache during Japanese post-marketing surveillance period.
- Trial name
- NCT01376193
- Testing
- Naratriptan
- Volunteers
- 500 people
- Sponsor
- GlaxoSmithKline
Primary Headaches (Includes Migraines, Tension, Cluster Headaches), Hydration
Hydration in Children and Adolescents With Primary Headaches
The aim of this study is to investigate the role of hydration and fluid intake in children and adolescents with primary headaches.
- Conditions
- Primary Headaches (Includes Migraines, Tension, Cluster Headaches), Hydration, Adolescent, Children
- Trial name
- H20KIDS (NCT06816849)
- Testing
- Recommended water intake
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Migraine Headache
Cupping and Serkangabin Versus Conventional Migraine Treatment
Migraine is the most common recurrent headache. Current therapy of migraine headache consists of multiple drug groups for control of attack and prophylaxis against recurrent attacks.
- Trial name
- NCT01476930
- Testing
- cupping and serkangabin syrup, conventional migraine drug treatment
- Where
- Iran
- Volunteers
- 391 people
- Sponsor
- Birjand University of Medical Sciences