Clinical trials: Procedural Pain in Newborns
Infant Development, Pain, Procedural
Parental Touch Trial (Petal)
This is a two centre two-arm randomised controlled interventional trial. We aim to determine whether parental touch prior to a painful clinical procedure provides effective analgesia in neonates.
- Conditions
- Infant Development, Pain, Procedural, Parents
- Trial name
- Petal (NCT04901611)
- Testing
- Parental touch
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Paediatric Neuroimaging Research Group
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Procedural Pain, Heel Prick
ShotBlocker and Warm Gel Pack During Neonatal Heel Prick (HEAL)
This study evaluated the effects of ShotBlocker and a warm gel pack on pain, comfort, and physiological parameters during heel prick testing in healthy term newborns.
- Conditions
- Procedural Pain, Heel Prick, Newborn
- Trial name
- HEAL (NCT07686627)
- Testing
- ShotBlocker, Warm Gel Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Marmara University
Procedural Pain
Skin Blood Flow Changes Using Laser Doppler Imager for Assessment of Pain and Analgesia in Newborn Infants
The purpose of this study is to assess whether an instrument, the Laser Doppler Imager, is able to measure the effect of pain related changes in skin blood flow in newborn infants.
- Trial name
- NCT00694174
- Testing
- sucrose 24% oral solution, sterile water
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Children's Hospital of Michigan
Procedural Pain, Preterm Infants
Effectiveness of Gentle Touch Technique on Pain Level During Painful Procedures in Preterm Infants
Preterm infants in neonatal intensive care units frequently undergo painful procedures that may affect their physiological stability, including pain level and respiratory parameters.
- Trial name
- NCT07470398
- Testing
- Gentle Touch Technique
- Where
- 3 sites in Iraq
- Volunteers
- 60 people
- Sponsor
- Karbala University
Prevention of Procedural Pain, Reduction of Procedural Pain
Non-pharmacological Interventions for Procedural Pain in Premature Neonates
A. Specific Aims Premature infants admitted to the neonatal intensive care unit (NICU) require up to several hundred procedures during their hospitalization.
- Conditions
- Prevention of Procedural Pain, Reduction of Procedural Pain, Biochemical Effects of Oral Dextrose
- Trial name
- NCT02214589
- Testing
- Oral glucose, facilitated tucking, NNS, Oral glucose and NNS, Facilitated tucking and NNS
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Loma Linda University
Neonatal Pain, Procedural Pain
Effect of ShotBlocker and Warm Gel Pack on Heel Stick Pain in Newborns
Newborns routinely undergo heel stick procedures for blood screening tests shortly after birth. Although the procedure is brief, it can cause pain, stress, and physiological changes.
- Trial name
- WARM-SHOT (NCT07921628)
- Testing
- ShotBlocker, Warm Gel Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Istinye University
Procedural Pain
Analgesic Effect of Breastmilk for Procedural Pain in Preterm Infants
Hypothesis: Breastmilk has a more powerful analgesic effect than oral sucrose to avoid procedural pain in preterm neonates. The objective is to test this hypothesis in a randomized, controlled study using a standardized and…
- Trial name
- BMoS (NCT00908401)
- Testing
- Breastmilk, Oral Sucrose
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Procedural Pain, Congenital Heart Disease
Procedural Pain Management by Multimodal Sedation Analgesia Combining Hypnosis in Children With Congenital Heart Disease
The aim of this prospective randomized controlled trial is to evaluate therapeutic hypnosis as a co-analgesia in thoracic drain removal in children with congenital heart disease.
- Conditions
- Procedural Pain, Congenital Heart Disease, Heart Surgery, Hypnosis
- Trial name
- PEACE-HYPNO (NCT06373627)
- Testing
- Hypnosis, Conventional medications used for sedation-analgesia, Medications used in addition to hypnosis
- Volunteers
- 104 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Procedural Pain
Intranasal Versus Intravenous Fentanyl For Procedural Analgesia in Preterm Neonates
Pain in neonatal life has profound long-term developmental impacts, so pain control is crucial. The intranasal (IN) route is a minimally invasive method for rapidly delivering fentanyl to provide short-term analgesia and sedation…
- Trial name
- NCT07190625
- Testing
- fentanyl intravenous, Fentanyl intranasal using atomizer, fentanyl intranasal direct
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Pain, Procedural Pain
The Effect of Pain Management Education on The Mothers in Newborn
The aim of this study was to determine the effect of non-pharmacological pain management education given to mothers on the use of non-pharmacological methods and anxiety levels of mothers during routine heel blood collection…
- Conditions
- Pain, Procedural Pain, Infant ALL
- Trial name
- NCT05173662
- Testing
- Providing education and brochures on non-pharmacological methods that can be applied during the heel blood collection process
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Pain
Sucrose Practices for Pain in Neonates
Recent studies show that babies in hospital undergo an average of 4 to 5 painful procedures, such as heel lances, every day. Sucrose (sugar water) has been shown to be effective for reducing pain during invasive procedures and is…
- Trial name
- SPiN (NCT02134873)
- Testing
- sucrose
- Where
- Canada
- Volunteers
- 291 people
- Sponsor
- The Hospital for Sick Children
Procedural Pain
Paternal vs Maternal Holding-Cuddling for Procedural Pain in Healthy Term Neonates
This study investigated the effect of maternal holding-cuddling (MHC) and paternal holding-cuddling (PHC) on heel prick pain and crying duration in healthy term neonates
- Trial name
- NCT06111534
- Testing
- Holding
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Post Procedural Pain Management in Neonates
Comparison of Minimal Effective Dose of Sucrose for Pain Relief in Neonates After Minor Procedure
Type of Study: Randomized Controlled Trial Aim: To compare the effectiveness of two doses of sucrose solution for pain relief in neonates after minor procedures.
- Trial name
- NCT06446323
- Testing
- 0.2 ml dose of sucrose
- Where
- Pakistan
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Pain, Procedural Pain
Utilization of Oral Sucrose to Decrease Pain in Infants During Immunizations
The study explores the potential benefits of a sugar water solution for decreasing pain in infants during routine immunizations.
- Trial name
- NCT00150189
- Testing
- Sucrose
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Hemodialysis, Virtual Reality
Effect of Virtual Reality on Cannulation-Related Procedural Pain, Distress and Comfort Level in Hemodialysis Patients
This study aimed to determine the effects of virtual reality on procedural pain, distress and comfort levels during cannulation in hemodialysis patients.
- Trial name
- Hemodialysis (NCT07281144)
- Testing
- Virtual Reality
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Procedural Pain
Analgesic Effect of Low Level Laser for Procedural Pain in Newborn Infants
Neonates undergo several painful procedures and these pain experiences can alter clinical outcome and behavior. The investigators aim to investigate the analgesic effect of low level laser for procedural pain during heel lancing…
- Trial name
- NCT03268148
- Testing
- LaserPen
- Where
- Taiwan
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Pain
NeoFent-I Study; Fentanyl Treatment in Newborn Infants; a Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Study
The study will assess the efficacy of fentanyl using a pharmacokinetic/pharmacodynamic (PK/PD) model where the concentration of the drug is related to effect curve (pain score change in response to standardized procedural pain).
- Trial name
- NCT03897452
- Testing
- Fentanyl (5 microgram/ml) prediluted ampoules
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Lund University
Pain
Breast Milk vs Sucrose in Relieving Procedural Pain in Preterm Neonates During Blood Draw by Automated Heel Lance
Skin breaking procedure through an automated heel lancet for blood draws is a common painful procedure in the Neonatal Intensive care unit (NICU). Recurrent pain in preterm neonates is associated with long-term complications.
- Trial name
- NCT04898881
- Testing
- Breast Human Milk, 24 % Sucrose
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Wayne State University
Pain, Procedural, Pain, Acute
Effect of Reflexology on Pain Management in Newborns
Introduction: Approximately 10-14 painful procedures per day are performed in preterm and term infants during the hospital stay in the first week.
- Conditions
- Pain, Procedural, Pain, Acute, Analgesia
- Trial name
- NCT05235893
- Testing
- Reflexology, Sucrose %24, Kangaroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Marmara University