Clinical trials: Procedural Sedation
Procedural Anxiety, Procedural Pain
Oral Surgery Virtual Reality Glasses Study
The goal of this randomized trial is to investigate if using virtual reality (VR) glasses for patients who require non-emergent oral surgery procedures under intravenous (IV) sedation improves their overall experience compared to…
- Trial name
- NCT06723158
- Testing
- Virtual reality (VR) glasses with relaxation module
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston University
Pediatric Cancer, Analgesia
Intranasal Versus Intravenous Drug in Painful Procedure for Outpatient Oncologic Participants
Pain is a vital sign that depends on personal experience involving different factors such as previous sensory and emotional experience, age, spiritual and cultural aspects, that makes it harder to evaluate, especially in young…
- Conditions
- Pediatric Cancer, Analgesia, Procedural Pain
- Trial name
- NAIVe (NCT04621110)
- Testing
- intranasal dexmedetomidine, intranasal fentanyl, intravenous ketamine (ketalar®)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Bone Fractures
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children
This study will examine the effectiveness of intranasal (IN) ketamine compared to standard intravenous (IV) ketamine administration for simple reductions of orthopaedic injuries in the paediatric population.
- Trial name
- NCT02402868
- Testing
- Ketamine and saline
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dental Anxiety
Nebulized Midazolam, Dexmedetomidine, and Their Combination in Sedation of Preschoolers Undergoing Dental Treatment
The aim of the study is to evaluate the effect of nebulized Midazolam, Dexmedetomidine, and their combination as procedural, moderate sedative agents in preschoolers undergoing dental treatment.
- Trial name
- NCT03827408
- Testing
- Midazolam group (MDZ), Dexmedetomidine group (DEX), Combination of Midazolam and Dexmedetomidine (MDZ/DEX)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Nourhan M.Aly
Shoulder Dislocation, Joint Dislocation
Ultrasound-Guided Low-Volume Brachial Plexus Block in the Supraclavicular Region for Shoulder Reduction in the Emergency Department
Acute shoulder dislocation is a common and painful condition in the emergency department (ED). Procedural sedation is widely used to facilitate reduction but is associated with potential risks and resource use.
- Trial name
- LOW-ST-SD (NCT07544485)
- Testing
- Ultrasound-guided brachial plexus block
- Where
- Switzerland
- Volunteers
- 206 people
- Sponsor
- Merian Iselin Klinik
Conscious Sedation
Procedural Sedation And Analgesia in Children in the Emergency Department: The Role of Adjunct Therapies
The role of Adjunct therapies such as Child Life therapy and Music listening during Procedural Sedation and Analgesia(PSA) for children during painful procedures has not been studied in the Emergency Department (ED).
- Trial name
- NCT02518919
- Testing
- Child life intervention, Music listening
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Children's Hospital of Michigan
Pain
Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation
This protocol describes a double-blind, placebo-controlled trial intended to demonstrate the effectiveness of lidocaine at reducing pain associated wiht propofol infusion for short-term deep sedation in children.
- Trial name
- NCT00786916
- Testing
- normal saline, lidocaine
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
Sedation
Dexmedetomidine Versus Pentobarbital for Pediatric Procedural Sedation
The investigators believe dexmedetomidine will provide superior sedation with reduced side effects and reduced time to discharge compared with pentobarbital.
- Trial name
- NCT00878345
- Testing
- dexmedetomidine sedation protocol, pentobarbital sedation protocol
- Where
- United States
- Sponsor
- Washington University School of Medicine
Forearm Fracture
Hematoma Block as an Adjunct to Procedural Sedation for Forearm Fracture Reduction
The purpose of our study is to determine if the use of a hematoma block together with intravenous sedation and analgesia is an effective means of managing forearm fractures in the Emergency Department.
- Trial name
- NCT00763880
- Testing
- Lidocaine, Saline
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Procedural Sedation and Analgesia
PRedictors Of Maladaptive Behaviors in Children Undergoing Procedural SEDation
Procedural sedation for children outside of the operating room is a common practice in emergency departments, outpatient clinics, radiology suites, and dental offices for painful and anxiety-provoking procedures.
- Trial name
- PRoSEED (NCT07495826)
- Where
- 2 sites in Canada
- Volunteers
- 2,145 people
- Sponsor
- London Health Sciences Centre Research Institute
Procedural Anxiety
Virtual Reality as a Substitute to Pharmacological Sedation During PICC Placement in Pediatric Patients
In pediatric patients Peripherally Inserted Central Catheters (PICC) insertion requires pharmacological sedation provided by an anesthesiologist, which poses a certain degree of risks.
- Trial name
- ViVA (NCT05275621)
- Testing
- Virtual Reality, PICC positioning
- Where
- 6 sites in Italy
- Volunteers
- 120 people
- Sponsor
- ASST Fatebenefratelli Sacco
MRI Sedation
Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans
This is a randomized, double-blind, dose-ranging study of the efficacy and safety of dexmedetomidine (DEX) when used with propofol as needed, for procedural sedation of pediatric subjects ≥1 month to <17 years of age undergoing…
- Trial name
- NCT04237792
- Testing
- dexmedetomidine, propofol
- Where
- 23 sites in United States, Japan
- Volunteers
- 128 people
- Sponsor
- Pfizer
Procedural Sedation and Analgesia During Bone Marrow Aspiration and Biopsy
Dexmedetomidine Versus Midazolam Added to Ketamine in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy
Group I :The patients will receive midazolam intravenously (i.v.) in a dose of 0.05 mg/kg diluted by 50ml saline over 10 minutes using syringe pump plus 1 mg/kg ketamine (iv).
- Trial name
- NCT03647579
- Testing
- midazolam intravenous infusion of 0.05 mg/kg plus 1 mg/kg ketamine, Dexmedetomidine intravenous infusion of 2mic/kg plus 1 mg/kg ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sedation
Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation
In Korea, oral chloral hydrate is still widely used for pediatric procedural sedation. The primary objective of the study is to evaluate the effect of intranasal dexmedetomidine (2mcg/kg) and ketamine (3mg/kg) on the success rate…
- Trial name
- NCT04822064
- Testing
- Intranasal dexmedetomidine and ketamine, Oral chloral hydrate
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Procedural Pain
Pharmacogenetics of Ketamine in Children
The need to treat the children with painful diagnostic-therapeutic procedures has increased in the last years. There is evidence from a wide scientific literature that drugs available in the setting of procedural sedation and…
- Trial name
- NCT05796232
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Burlo Garofolo
Sedation Complication
A Dedicated Sedation Team for Paediatric Procedural Sedation
At a tertiary care university hospital a specialized interdisciplinary team of paediatric anaesthesiologists and paediatric intensivists was established for providing analgosedation for diagnostic and therapeutic procedures.
- Trial name
- NCT04760249
- Volunteers
- 784 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sedation
Intranasal Ketamine Versus Intramuscular Ketamine for Procedural Sedation in Pediatric Patients
The purpose of this study is to determine if intranasal ketamine is equally as effective and safe as intramuscular ketamine for procedural sedation in pediatric patients.
- Trial name
- NCT01170247
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Emergency Department Procedural Sedation, Fracture Reduction
Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia
When patients come to the Emergency Department with injuries and infections they often need to have painful procedures performed that are essential to allowing them to recover.
- Conditions
- Emergency Department Procedural Sedation, Fracture Reduction, Abscess Incision and Drainage, Electrical Cardioversion
- Trial name
- NCT01211158
- Testing
- Ketofol, Propofol alone
- Where
- Canada
- Volunteers
- 284 people
- Sponsor
- Lions Gate Hospital
Sedation
Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children
In Korea, oral chloral hydrate is still widely used for pediatric procedural sedation. The primary objective of the study is to evaluate the effect of intranasal dexmedetomidine (2mcg/kg) and ketamine (3mg/kg) on the…
- Trial name
- NCT04820205
- Testing
- Intranasal dexmedetomidine and ketamine, Oral chloral hydrate
- Where
- South Korea
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anesthesia, Sedation
EEG Signal Correlates During Anesthesia and Sedation in Adults and Children
This prospective, multicenter, non-interventional observational study investigates the correlates between electroencephalographic (EEG) signals and pharmacological/clinical parameters during general anesthesia and procedural…
- Conditions
- Anesthesia, Sedation, Consciousness Monitors
- Trial name
- SPECTRALADUPED (NCT07460414)
- Where
- 2 sites in France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris