Clinical trials: Progression
HIV Infections
A Study of Disease Progression and Anti-HIV Treatments
To determine the influence of virus load, CD4 count, biologic phenotype, and presence of symptomatic disease on the response of HIV-infected patients to a new therapeutic regimen.
- Trial name
- NCT00001068
- Testing
- Lamivudine
- Where
- 41 sites in United States, Puerto Rico and 1 more
- Volunteers
- 210 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Desmoid
Radiomics Compared With Conventional Response Criteria for Predicting Progression of Desmoid Tumor After Cryoablation
Desmoid tumors (DT) are uncommon tumors that arise from musculoaponeurotic structures. Despite benign, they can cause pain and disability due to their tendency to be locally aggressive.
- Trial name
- Cryomics (NCT06224283)
- Testing
- Cryoablation
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Istituto Ortopedico Rizzoli
Type 1 Diabetes Mellitus
Rituximab in New Onset Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas.
- Trial name
- TN05 (NCT00279305)
- Testing
- Anti-CD20 (rituximab)
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 87 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Puberty Changes
Indicators and Evaluation of Efficacy of Yin-nourishing and Fire-reducing Chinese Medicine for Girls With Rapid Progression of Early Puberty
1. Evaluate whether AMH and SHBG have differential expression before and after the diagnosis of rapid and slow progression types of early puberty and whether this difference has a predictive effect on the rapid progression type.
- Trial name
- NCT06820931
- Testing
- Xuandi Ziyin Mixture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Children's Hospital of Fudan University
Work-Related Stress
Informal Caregivers at Work - Phase 2
Mental health problems are rising among children and adolescents. This may not only impact the child's level of daily functioning but also close family members.
- Trial name
- PPJob-II (NCT06441461)
- Testing
- Primary informal caregiver at work.
- Where
- Denmark
- Volunteers
- 4,386,647 people
- Sponsor
- Team Working Life Denmark
Diabetes Mellitus, Diabetes Mellitus Progression
Rare and Atypical Diabetes Network
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders
- Trial name
- RADIANT (NCT05544266)
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of South Florida
Myopia
Myopia Progression and the Effect of 7-Methylxanthine
7-methylxanthine has been shown to increase the concentration and thickness of collagen fibrils in rabbit sclera. Deficient collagen in the sclera may be the cause of progression of childhood myopia.
- Trial name
- NCT00263471
- Testing
- 7-methylxanthine
- Volunteers
- 90 people
- Sponsor
- Trier Research Laboratories
Rhinitis, Asthma
Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma
This is a prospective observational study , to clarity the characteristics of airway inflammation, airway reactivity and airway resistance in rhinitic children with or without asthma and to explore the possible predictors in the…
- Conditions
- Rhinitis, Asthma, Inflammation, Hypersensitivity
- Trial name
- NCT02360072
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Myopia
Evaluate the Safety and Efficacy of Two Types of Circular Column Modulated Lenses for Delaying the Progression of Myopia
Clinical trial to evaluate the safety and effectiveness of two kinds of ring band cylindrical lens in delaying the progression of myopia
- Trial name
- NCT05288335
- Testing
- Circular cylindrical mirror modulated frame glasses (compact), Circular cylindrical mirror modulated frame glasses (strong defocus), single vision frame glasses
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Attention-deficit Hyperactivity Disorder
A Study to Examine the Progression of Attention-Deficit Hyperactivity Disorder (ADHD) Drug Treatment and to Analyze Associated Factors
The purpose of this observational study is to explore the efficacy of methylphenidate hydrochloride in children and adolescents diagnosed with attention-deficit hyperactivity disorder (ADHD) by Kiddie-scheduled for affective…
- Trial name
- NCT01624649
- Testing
- Methylphenidate hydrochloride, Atomoxetine
- Where
- 9 sites in South Korea
- Volunteers
- 289 people
- Sponsor
- Janssen Korea, Ltd., Korea
Myopia, Myopia Progression
Evaluation of Performance of MiYOSMART Photochromic and Clear Spectacle Lenses in Myopic Children
This clinical study aims to evaluate the non-inferiority of the photochromic DIMS spectacles lenses performance (PDIMS) compared to clear DIMS spectacles lenses (DIMS) in myopia management.
- Trial name
- PDIMS (NCT06717035)
- Testing
- EYE001
- Where
- Singapore
- Volunteers
- 202 people
- Sponsor
- Singapore National Eye Centre
Regional Blood Flow
Choroidal Blood Flow and Progression of Age-Related Macular Degeneration in the Fellow Eye in Patients With Unilateral Choroidal Neovascularisation
Age-related macular degeneration (AMD) is the chief cause of severe and irreversible loss of vision in developed countries. The prevalence of AMD increases dramatically with age.
- Trial name
- NCT00808197
- Testing
- ocular blood flow measurement
- Where
- Austria
- Volunteers
- 41 people
- Sponsor
- Medical University of Vienna
Glaucoma, Filtering Surgery
Long-Term IOP Fluctuation and VF Progression After Triple Procedure
Long-term intraocular pressure (IOP) fluctuation may be significantly associated with the progression of glaucomatous visual field loss, even in patients kept always low IOP after triple procedure, an effective approach for…
- Conditions
- Glaucoma, Filtering Surgery, Intraocular Pressure
- Trial name
- NCT00428740
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Viral Pneumonia, COVID
Imaging Feature of SARS-CoV2 Infection
The novel coronavirus SARS-CoV2 clinically presents with pneumonia, characterised by fever, cough, dyspnea. The severity of the disease varies widely with evidence of mild disease in the majority of confirmed cases, severe…
- Trial name
- COVID19IF (NCT04394026)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Francesco De Cobelli
Myopia
A Clinical Trial to Evaluate the Efficacy and Safety of Defocusing Lenses in Delaying Myopia Progression
The objective of this clinical trial was to evaluate the efficacy and safety of defocusing lenses for delaying myopia progression in children and adolescents.
- Trial name
- NCT06411717
- Testing
- Microstructure lens A, Microstructure lens B, Control group
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Suzhou Care-Real Medical Technology Co., Ltd.
Atopic Dermatitis, Psoriasis
Disease Trajectories and Anti-cytokine Response Signatures in Atopic Dermatitis and Psoriasis
The clinical study investigates the long-term course of disease in patients with chronic inflammatory skin diseases (atopic eczema and psoriasis) and the impact of tarheted therapies on the clinical and molecular level.
- Conditions
- Atopic Dermatitis, Psoriasis, Healthy
- Trial name
- DiTrAP (NCT03361215)
- Testing
- Biosampling for molecular analysis
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Neuroendocrine Carcinoma of Lung, Neuroendocrine Carcinoma of Thymus
CompArative Analysis Between, Thymic, pulmonaRy and Pancreatic Well Differentiated High Grade Neuroendocrine Tumors
The study involves the enrollment of 34 patients diagnosed with advanced thymic, pulmonary and duodeno-pancreatic well-differentiated high grade neuroendocrine tumors (Ki-67 > 20%).
- Trial name
- LINEAR (NCT07429851)
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- European Institute of Oncology
Myopia, Children
Study of Atropine Therapeutic Effect on Myopic Progression
This study is to evaluate the therapeutic effect and safety of LPTAT in children with myopia.
- Trial name
- STAMP (NCT05529056)
- Testing
- Atropine Sulfate 01, Atropine Sulfate 02, Atropine Sulfate 03
- Where
- 15 sites in South Korea
- Volunteers
- 472 people
- Sponsor
- LitePharmTech Co., Ltd.
Myopia, Progressive
Choroidal Response to Novel Spectacle Lens to Control Myopia Progression
Diurnal variations in the thickness of the choroid have been reported in the literature, and, more recently, the role of the choroid has been studied with respect to its role in myopia (near-sightedness) progression.
- Trial name
- CHERRY (NCT03818880)
- Testing
- Novel spectacle lens design
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Parkinson Disease
Assessing Tele-Health Outcomes in Multiyear Extensions of PD Trials
An observational study to characterize and compare long-term clinical outcomes data collected remotely through periodic tele-visits, interactive smartphone app sessions, and web-based surveys in individuals with Parkinson's…
- Trial name
- AT-HOME PD (NCT03538262)
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Massachusetts General Hospital