Clinical trials: Progression
Fabry Disease
A Study of the Safety and Efficacy of Fabrazyme (Agalsidase Beta) as Compared to Placebo in Patients With Advanced Fabry Disease
People with Fabry disease have an alteration in their genetic material (DNA) which causes a deficiency of the a-galactosidase A enzyme.
- Trial name
- NCT00074984
- Testing
- Fabrazyme (agalsidase beta)
- Where
- 26 sites in United States, Canada and 4 more
- Volunteers
- 82 people
- Sponsor
- Genzyme, a Sanofi Company
Myopia, Progressive, Children, Only
Eleven Years of Menicon Z Night Contact Lens Wear in Reducing Myopia Progression in Children
To compare axial length growth of white European myopic children wearing Menicon Z Night orthokeratology contact lenses to a control group of distance, single-vision glasses and contact lenses over an 11-year period.
- Trial name
- MCOS11 (NCT04806711)
- Testing
- Menicon Z Night, Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Menicon Co., Ltd.
Scoliosis
Study of the Surgical Treatment of Early Onset Scoliosis Using a Non-invasive Growing Rod
It is current practice for children who have surgery for early onset scoliosis (EOS) to be treated with insertion of extendable implants known as growth rod systems.
- Trial name
- NCT01362881
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- Ellipse Technologies, Inc.
Pseudomonas Aeruginosa
Molecular Detection Of Efflux Pump and Virulence Factors Genes in Pseudomonas Aeruginosa
Pseudomonas aeruginosa (PA) is a ubiquitous aerobic, non-fermentative Gram-negative rod that is widely associated with nosocomial pneumonia and can lead to severe illness with poor outcomes, particularly in critically ill people…
- Trial name
- Pseudomonas (NCT05642767)
- Testing
- culture on cetrimide agar, Staining with Gram stain, Antibiotic sensitivity testing
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Sohag University
Dental Caries
Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial
Dental caries is a highly prevalent disease in children. Contemporary caries management emphasizes minimally invasive approaches that aim to arrest or reverse non-cavitated lesions rather than remove tooth structure.
- Trial name
- REMİN-PRİMARY (NCT07431463)
- Testing
- P11-4 + NaF Varnish, Silver diamine fluoride, NaF Varnish Alone
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Izmir Katip Celebi University
Myopia
Impact of Electronic Devices on Myopia Development and Progression
The aim of the stuy is to investigate the effects of the adoption of a curriculum with electronic devices for teaching materials and textbooks in Hong Kong schoolchildren on their changes in refractive error and visual function.
- Trial name
- NCT02150421
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
REM Sleep Behavior Disorder
Establish a National Registry of REM Sleep Behavior Disorder
In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.
- Trial name
- NCT03671798
- Where
- Hong Kong
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Low Back Pain, Spondylosis
Back in the Game: An Immediate Functional Progression Program in Athletes With a Spondylolysis.
Half of all adolescents report experiencing low back pain (LBP), and adolescents who are active in sport report an even higher rate.
- Trial name
- NCT03237104
- Testing
- Immediate PT
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Nationwide Children's Hospital
Description of Disease Course, Disease Fenotype, Medication, Safety, Analysis for Possible Associations
Registry of Pediatric Patients Diagnosed With Crohn's Disease in Belgium
A registry of pediatric patients (under 18 yrs of age) diagnosed with Crohn's disease was created in Belgium. Over a 2 year period 257 patients are included. These patients will be follow up prospectively during 5 years.
- Trial name
- Belcro (NCT01241058)
- Where
- Belgium
- Volunteers
- 257 people
- Sponsor
- Gigi Veereman
Myopia
Myopia Progression Trial With Novel Myopia Control Design Spectacle Lenses
This is a mono-center, randomized, double-masked, cross-over study to evaluate rate of myopia progression with novel designed myopia control lens (test) compared to SVL (control).
- Trial name
- NCT04048148
- Testing
- Novel designed myopia control spectacle lenses
- Where
- Vietnam
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Brien Holden Vision Institute
Myopia Progression
Factors Influencing Physiological Hyperopia in Children
The trend of myopia in children and its low age is a major social and public health problem in China. More seriously, retinopathy associated with high myopia has become the number one cause of irreversible blinding eye disease in…
- Trial name
- NCT06498947
- Testing
- This study was observational with no intervention.
- Where
- China
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Viral Pneumonia, COVID
Imaging Feature of SARS-CoV2 Infection
The novel coronavirus SARS-CoV2 clinically presents with pneumonia, characterised by fever, cough, dyspnea. The severity of the disease varies widely with evidence of mild disease in the majority of confirmed cases, severe…
- Trial name
- COVID19IF (NCT04394026)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Francesco De Cobelli
Autosomal Dominant Polycystic Kidney Disease
Role of ROS and cAMP-PKA Biomarkers in ADPKD
The primary objective is to determine the prognostic value of markers of ROS and cAMP-PKA signaling to assess disease severity and progression in patients with ADPKD.
- Trial name
- NCT07217158
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Bladder Cancer, Bladder Cancer Recurrence
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study
Bladder cancer is common tumor in which recurrence and/or progression in patients undergoing TUR has been reported to range between 30% and 80% in patients with NMIBC TCC.
- Trial name
- NCT07657299
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Breast Cancer
Treatment After Progression of Fulvestrant Among Metastatic Breast Cancer Patients
What Comes After Fulvestrant? A Real World Multicenter Retrospective Study-Treatment After Progression of Fulvestrant Among Metastatic Breast Cancer Patients in China.
- Trial name
- NCT03541863
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Fudan University
Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Childhood, Recurrent
Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy
The aim of this study is to assess the safety and efficacy of AloCELYVIR, which consist in bone marrow-derived allogenic mesenchymal stem cells infected with an oncolytic Adenovirus, ICOVIR-5.
- Trial name
- AloCELYVIR (NCT04758533)
- Testing
- AloCELYVIR
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Neuronal Ceroid Lipofuscinosis, Batten Disease
Natural History and Longitudinal Clinical Assessments in NCL / Batten Disease, the International DEM-CHILD Database
This is an observational study that aims at assessing the natural history of NCL diseases as part of the international DEM-CHILD Database. 1.
- Conditions
- Neuronal Ceroid Lipofuscinosis, Batten Disease, CLN1 Disease, CLN2 Disease
- Trial name
- NCT04613089
- Testing
- Natural History
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Myopia, Myopia Progression
Mobility Performance in Daily Activities Among Children Wearing Spectacle Lenses
The aim of this study is evaluate and compare the mobility performance of children in daily activities while wearing single vision spectacle lenses (control) versus myopia control spectacle lenses (test).
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- NCT07229352
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia
Myopia Intervention in Children and Adolescents and Establishment of a Precise Intervention Model
Investigators are going to conduct a multi-centered randomized clinical trial that myopic children are randomly allocated into three groups: 0.01% atropine， 0.04% atropine and orthokeratology in order to evaluate the efficacy and…
- Trial name
- NCT05357326
- Testing
- Atropine Sulfate 0.01% Eye Drop, Orthokeratology, Atropine Sulfate 0.04% Eye Drop
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
HIV Disease Progression
Acceptability, Feasibility and Effectiveness of Online Peer Support Group for ART Adherence Among Youth
In Uganda, Youth living with HIV/AIDS (YLHIVA) enrolled in HIV treatment experience suboptimal treatment adherence and have lower viral load suppression (VLS) rates compared to younger children or adults.
- Trial name
- NCT05688709
- Testing
- WhatsApp peer support group
- Where
- 3 sites in Uganda
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda