Clinical trials: Proof of Concept
Myopia
Red Light Childhood Myopia Proof-of-concept
In this project the research team will begin to find out whether shining a red LED light at the eyes can slow down the worsening of short-sightedness in children.
- Trial name
- NCT06771258
- Testing
- Red Light (PDT)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Depression
Exercise + Self-Compassion Intervention for Depression
An alarming number of students report depressive symptoms that make it difficult to function academically. Previous research has indicated that exercise can be effective in treating mild-moderate depression.
- Trial name
- NCT04572035
- Testing
- Behavioural Coaching, Self-compassion psychoeducation, Exercise
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Inherited Epidermolysis Bullosa
A Double-blind, Intra-individual Comparison, POC Trial of AC-203 in EB Patients
Inherited epidermolysis bullosa (EB) is a genetic skin disorder characterized by skin fragility and recurrent blister formation.
- Trial name
- NCT03468322
- Testing
- AC-203, Vehicle
- Where
- 2 sites in Taiwan
- Volunteers
- 9 people
- Sponsor
- TWi Biotechnology, Inc.
Critical Illness, Safety Issues
TraceBook: the Clinical Proof of Concept on the Intensive Care.
The effectiveness of current checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual…
- Trial name
- TraceBook (NCT03599856)
- Testing
- TraceBook
- Where
- Netherlands
- Volunteers
- 408 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Parkinson Disease, Mild Cognitive Impairment
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Memory Impairment
- Trial name
- TRIP (NCT04643327)
- Testing
- Levetiracetam
- Where
- Australia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Type I Gaucher Disease
Clinical Trial of Ambroxol in Patients With Type I Gaucher Disease
Ambroxol is expected to improve the signs and symptoms of patients with Type I Gaucher Disease.
- Trial name
- NCT01463215
- Testing
- Ambroxol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Exsar Corporation
Primary Study Outcome: Sodium Clearance in Dialysis, Solute Removal
Proof of Concept of Adapted PD in Children (PC-AAPD)
The purpose of this study is to validate the concept of adapted automated PD a modified Peritoneal Equilibration Test (PET), will be performed in children on chronic PD.
- Conditions
- Primary Study Outcome: Sodium Clearance in Dialysis, Solute Removal, Ultrafiltration
- Trial name
- PC-AAPD (NCT02748733)
- Testing
- Adapted double mini PET, Standard double mini PET
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
Visceral Leishmaniasis
Trial to Determine Efficacy of Fexinidazole in Visceral Leihmaniasis Patients in Sudan
This study is designed to determine the efficacy of Fexinidazole as an oral treatment in Visceral Leishmanisasis sudanese adults patients.
- Trial name
- NCT01980199
- Testing
- Fexinidazole
- Where
- Sudan
- Volunteers
- 14 people
- Sponsor
- Drugs for Neglected Diseases