Clinical trials: Prophylactic
Post-Measles Pneumonia, Measles
Prophylactic Antibiotics in Measles
Objective It is the objective to test whether the use of prophylactic antibiotics in measles infection will reduce the incidence of post-measles pneumonia and/or admissions to hospital with 50%.
- Trial name
- NCT00168532
- Testing
- Sulfamethoxazole-Trimethoprim
- Where
- Guinea-Bissau
- Volunteers
- 218 people
- Sponsor
- Bandim Health Project
Schizophrenias, Psychoses
Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia
The purpose of this study is to determine whether preventative treatment with sarcosine can reduce symptoms and delay/avoid disease progression in individuals defined as being in a prodromal stage of schizophrenia.
- Conditions
- Schizophrenias, Psychoses, Psychotic Disorders, Schizophrenic Disorders
- Trial name
- NCT00276263
- Testing
- Sarcosine (N-methylglycine)
- Where
- 2 sites in Israel
- Sponsor
- Herzog Hospital
Healthy
HIV-1 Vaccine Test in Uninfected Adult Volunteers
This study will test the safety of an experimental vaccine against HIV and examine whether it induces an immune response to HIV. A vaccine is a substance given to try to create resistance or immunity to a disease or infection.
- Trial name
- NCT00045838
- Testing
- VCR-HIVDNA006-00-VP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Laryngeal Cancer
Comparison of 2 Cefazolin Prophylactic Protocol in Laryngectomy Patients
Patients who need major head \& neck surgery are at risk of post operative wound infection. In spite of role of antibiotics in prophylaxis of clean contaminated head and neck surgery has been well documented, controversy exists…
- Trial name
- NCT00467948
- Testing
- cefazolin
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
HIV Positive, Herpes Simplex, Genital
Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes
To determine the efficacy of Famvir 500mg bd as suppressive antiviral therapy for acute genital Herpes simplex virus (HSV) outbreaks in HIV subjects.
- Trial name
- NCT01154543
- Volunteers
- 42 people
- Sponsor
- Holdsworth House Medical Practice
Prostate Cancer, Erectile Dysfunction
Study of Sildenafil Citrate During and After Radiotherapy/Hormone Therapy for Erectile Function Versus Radiotherapy/Hormone Therapy for Prostate Cancer
Radiation sometimes affects the ability for a person to have a normal erection. Complete loss of erections after radiation treatment can happen in 40-50% of treated patients.
- Trial name
- NCT00142506
- Testing
- sildenafil citrate and questionaires
- Where
- 5 sites in United States
- Volunteers
- 290 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Dental Caries
Fluoride Varnish For Childsmile Nursery School Attenders
The study will compare the effectiveness of Duraphat® fluoride varnish in preventing any further dental decay among 3-4 year old children in nursery schools.
- Trial name
- PT@3 (NCT01674933)
- Testing
- Duraphat® Fluoride Varnish, treatment as usual
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,610 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Covid19
COVID 19 Preventive Measures Among Mansoura Nursing Students
This study aims to identify nursing students knowledge gaps, risk perceptions and adherence to COVID 19 preventive measures during written exam period and In addition due to the possibility of being infected with COVID-19 during…
- Trial name
- NCT04473547
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Mansoura University
Cellulitis/Erysipelas of the Leg
RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg
To assess whether a period of prophylactic penicillin after an episode of cellulitis of the leg reduces the risk of repeat episodes. Participants are randomised to receive 12 months of prophylaxis (penicillin VK 250mg b.d.
- Trial name
- PATCH1 (NCT00552799)
- Testing
- Penicillin VK
- Where
- 25 sites in Ireland, United Kingdom
- Volunteers
- 274 people
- Sponsor
- University of Nottingham
Internet Use Disorders
Intervening in Problematic Internet Use
The present study examines the efficacy of a brief intervention for problematic Internet use based on Motivational Interviewing (MI) and Cognitive Behavioral Therapy (CBT) in a sample of students screened proactively in…
- Trial name
- iPIN (NCT03646448)
- Testing
- Motivational Interviewing
- Where
- Germany
- Volunteers
- 470 people
- Sponsor
- University of Luebeck
Cow Milk Allergy
Microbiota as Potential Target for Food Allergy
Food allergy (FA) derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for enteric microflora in oral tolerance development.
- Trial name
- MATFA (NCT02087930)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Federico II University
Dental Caries
Preventive Effect of a Probiotic Tablet on Oral Health in Preschool Children
The aim of the prospective project is to investigate effect of daily probiotic supplements on dental caries development in preschool children living in a low socioeconomic immigrant area in souithern Sweden.
- Trial name
- NCT01720771
- Testing
- probiotic tablet, sugar pill
- Where
- Sweden
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Dermatitis, Atopic
Efficacy Study of Topical Twice Weekly Fluticasone Treatment to Reduce Relapse in Atopic Dermatitis in Children
The relapsing nature of atopic dermatitis (AD) presents a challenge for its long-term treatment. Efficacy and safety of corticosteroids have been proven in the acute treatment of AD, but not its efficacy and security to reduce or…
- Trial name
- NCT01772056
- Testing
- Fluticasone, cream
- Where
- 4 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Elena Rubio Gomis
Infant, Newborn, Diseases, Prematurity
Prophylactic Surfactant by Thin Endotracheal Catheter for Preterm Infants At Birth: the ProTeCt Trial
The goal of this clinical trial is to learn whether giving surfactant through a thin endotracheal catheter to extremely premature babies shortly after birth reduces the number of them who are ventilated in the first 3 days of…
- Conditions
- Infant, Newborn, Diseases, Prematurity, Prematurity; Extreme, Respiratory Distress Syndrome in Premature Infant
- Trial name
- proTeCt (NCT06557551)
- Testing
- Thin catheter surfactant
- Where
- Ireland
- Volunteers
- 164 people
- Sponsor
- University College Dublin
Chronic Disease, Arthritis
Deep Dive Randomized Control Trial
Compare two care management support program models on medical costs and utilization.
- Conditions
- Chronic Disease, Arthritis, Uterine Diseases, Spinal Diseases
- Trial name
- NCT00793260
- Testing
- Enhanced Support, Usual-Support
- Where
- United States
- Volunteers
- 174,120 people, healthy volunteers welcome
- Sponsor
- Health Dialog
Heart Block, CIED Related Infection
Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation
Effect of single dose \& intrapocket prophylactic antibiotic to cardiac implantable electronic device-related infection \& biomarkers
- Conditions
- Heart Block, CIED Related Infection, CIED-related Infections, Antibiotic Prophylaxis
- Trial name
- BI-PACED (NCT06448624)
- Testing
- Ampicillin sulbactam 3 days
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Diponegoro
Malaria
Pharmacokinetics of Sulfadoxine-pyrimethamine Plus Amodiaquine for Intermittent Preventive Treatment in Children (IPTc)
The aim of the study is to determine the pharmacokinetic profile of sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ) when used for seasonal Intermittent Preventive Treatment (IPT) to prevent malaria in children aged 3 to 59…
- Trial name
- NCT01328990
- Testing
- sulfadoxine-pyrimethamine plus amodiaquine
- Where
- Senegal
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Dental Caries, Dental Plaque
RCT on Effectiveness of Oral Health Preventive Programmes in School Children in Uganda
Dental caries represents a challenge for Oral Health Services in several African Countries, like Uganda. Few studies have been reported the burden of oral health, its prevention and non-operative treatment among school children…
- Conditions
- Dental Caries, Dental Plaque, Dental Diseases, Dental Caries in Children
- Trial name
- NCT06081868
- Testing
- Use of toothbrush/toothpaste/fluoride varnish, Education on nutrition/oral hygiene
- Where
- Switzerland
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- University of Bern
Lung Cancer
Brain Irradiation in Treating Patients With Limited-Stage Small Cell Lung Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which radiation therapy regimen is more effective in preventing brain metastases in patients with limited-stage small cell lung…
- Trial name
- NCT00057746
- Testing
- Prophylactic cranial irradiation, 2.5 Gy fx, Prophylactic cranial irradiation, 2.0 Gy fx, Prophylactic cranial irradiation, 1.5 Gy fx
- Where
- 222 sites in United States, Canada
- Volunteers
- 265 people
- Sponsor
- Radiation Therapy Oncology Group
Malaria
Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso
The aim of the study is to determine whether piperaquine plus dihydroartemisinin (DHA-PQ) is as effective, and better tolerated, than sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ), when used for seasonal Intermittent…
- Trial name
- NCT00941785
- Testing
- DHA-PQ, SP-AQ
- Where
- Burkina Faso
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine