Clinical trials: Prophylactic
Vaccine, Human Papiloma Virus Vaccine
State Immunization Information Systems to Improve HPV Vaccination Rates
The overarching goal of this study is to evaluate the effectiveness, cost-effectiveness and sustainability of utilizing statewide Immunization Information Systems (IIS) to conduct centralized reminder/recall (R/R) to improve…
- Conditions
- Vaccine, Human Papiloma Virus Vaccine, HPV Vaccine, Immunization
- Trial name
- NCT02993965
- Testing
- Vaccine Reminder/Recall
- Where
- United States
- Volunteers
- 77,716 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Malaria, Falciparum
Preventing Malaria During Pregnancy in Epidemic-prone Areas.
The purpose of this study is to compare the efficacy and cost-effectiveness of three alternative strategies for the prevention of malaria during pregnancy in an epidemic-prone area of low transmission in the East African…
- Trial name
- NCT00142207
- Testing
- Intermittent preventive treatment:sulphadoxine-pyrimethamine, Insecticide-treated mosquito bed net
- Where
- Uganda
- Volunteers
- 4,775 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Low Cardiac Output Syndrome
Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in Infants
Pediatric patients, especially infants undergoing open heart surgery have a predictable fall in cardiac index 6 to 18 hours after surgery, the so-called low cardiac output syndrome (LCOS).
- Trial name
- Levomil (NCT00549107)
- Testing
- Levosimendan, Milrinone
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Negative Pressure Wound Therapy, Cesarean Section; Infection
The Invia Motion at Cesarean Study
To assess patient centered outcomes of the Medela INVIA Motion prophylactic NPWT system at cesarean delivery.
- Trial name
- NCT04365452
- Testing
- Invia Motion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Emergence Delirium
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Fifty children undergoing heart catheterization without local anesthesia in the skin will be randomly divided into two groups. Group DM (Dexmedetomidine + Midazolam) and Group KM (Ketamine + Midazolam)
- Trial name
- NCT07427446
- Testing
- Dexmedetomidine and Midazolam, Ketamine and Midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Patient-centered Care
Impact of a Wellness Portal on The Delivery of Patient-Centered Preventive Care
Building upon our experience with a very sophisticated preventive services prompt and reminder system, the Preventive Services Reminder System (PSRS), the investigators propose to conduct a systematic three-year study with the…
- Trial name
- NCT01520662
- Testing
- Implementation of a secure web-based patient Wellness Portal
- Where
- United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Pertussis, Meningitis
Pertussis and Meningitis C Concomitant Vaccination in Adolescents
The trial includes groups receiving various combinations of meningitis C and pertussis containing vaccines, to be administered concomitantly in adolescents due their school leaving booster vaccinations (as per UK routine…
- Conditions
- Pertussis, Meningitis, Preventive Immunization; Meningitis, Immunization
- Trial name
- Mutliboost (NCT02526394)
- Testing
- Meningococcal vaccine, Pertussis containing vaccine
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Public Health England
Allergy
Microbiota and Allergy
Food allergy derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for gut microbiota in oral tolerance development.
- Trial name
- MATFA I (NCT04750980)
- Testing
- food allergy, respiratory allergy, healthy controls
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Federico II University
Immunization Reminder System
Accountable Care Organizations/ Public Health Collaborative
This study focuses on implementing and evaluating an evidence-based collaborative method of increasing immunization rates among preschool children, adolescents and adults within an Accountable Care Organization-Public Health…
- Trial name
- ACO/PH (NCT02133391)
- Testing
- Centralized Reminder/Recall (R/R), Practice-based Reminder/Recall
- Where
- United States
- Volunteers
- 78,354 people
- Sponsor
- University of Colorado, Denver
Atrial Fibrillation, Thromboembolism
Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence
Stroke is a major cause of morbidity in western society, and an infrequent complication of cardiac surgery. The majority of thromboembolic strokes arise from the left atrium, in particular the left atrial appendage.
- Conditions
- Atrial Fibrillation, Thromboembolism, Cerebrovascular Accident
- Trial name
- NCT00486915
- Testing
- Left Atrial Appendage Ligation
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre
Anxiety Disorders and Symptoms Depressive Symptoms, Risk Factors (Rejection, Bullying/Cyberbullying, Addictions, Healthy Lifestyle Habits, Exam Stress Management, Ecoanxiety, Expressed Emotion)
Selective Prevention Transdiagnostic Intervention for At-risk Adolescents With Booster Sessions. (PROCARE+ 2.0)
Emotional disorders such as anxiety and depression are significantly underdiagnosed and undertreated, even though they are some of the most prevalent mental health conditions, especially among young individuals.
- Trial name
- NCT06185049
- Testing
- PROCARE+ (Core intervention with add-on modules) and two booster sessions., PROCARE+ (Core intervention with add-on modules) and one booster session, PROCARE+ (Core intervention with add-on modules) without booster sessions.
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Jaén
Tuberculosis
Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults
The study is a randomized, double-blind, placebo-controlled, multicenter, clinical trial to assess the prophylactic efficacy, safety, and immunogenicity of the investigational M72/AS01E-4 Mtb vaccine when administered…
- Trial name
- NCT06062238
- Testing
- M72/AS01E-4 Mycobacterium tuberculosis investigational vaccine
- Where
- 54 sites in Indonesia, Kenya and 3 more
- Volunteers
- 20,080 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Mucopolysaccharidosis (MPS), Hunter Syndrome
A Study of ELAPRASE in Treatment-naïve Participants With Hunter Syndrome (Mucopolysaccharidosis [MPS] II)
The main aim of this study is to evaluate the ability of a prophylactic immune tolerizing regimen (ITR) to prevent or reduce the development of high titer anti-idursulfase antibodies in treatment-naïve participants with Hunter…
- Trial name
- NCT05494593
- Testing
- ELAPRASE, Rituximab, Methotrexate
- Where
- 8 sites in United States
- Sponsor
- Takeda
Dengue Hemorrhagic Fever, Awareness
Evaluating Public Awareness and Preventive Actions for Dengue Fever in Sudan Amidst Ongoing Crises
This study evaluates the awareness of dengue fever and preventive measures among Sudanese people during the war. It assesses knowledge, awareness, implementation of prevention, access to healthcare, community involvement, and the…
- Trial name
- NCT07205848
- Testing
- No intervention
- Where
- Sudan
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Research and Publication office
Calculi, Renal, PCNL
Preoperative Prophylactic Fosfomycin Trometamol Versus 5-day Levofloxacin in Prevention of Postpercutaneous Nephrolithotomy Infectious Complications and Sepsis.
A randomized controlled trial comparing the use of preoperative prophylactic single dose fosfomycin trometamol versus levofloxacin in prevention of post-PCNL infectious complications and sepsis.
- Conditions
- Calculi, Renal, PCNL, Infectious Complications
- Trial name
- NCT07355907
- Testing
- PCNL
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Tanta University
Asthma
Asthma in Families Facing Out-of-pocket Requirements Due to COVID-19
In addition to its impact on health, the COVID-19 pandemic led to increased unemployment and loss of employer-sponsored insurance coverage.
- Trial name
- AFFORD COVID (NCT04613739)
- Testing
- insurance navigation
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Harvard Pilgrim Health Care
Upper Respiratory Tract Infection
Probiotic S. Salivarius K12 for the Prevention of Upper Respiratory Tract Infection in Nursery-age Children
The purpose of this retrospective study is to assess the treatment benefits of probiotic Streptococcus salivarius K12 for the prevention of recurrent bacterial and viral infections of the pharynx, tonsils and ears in children…
- Trial name
- PUNK (NCT05840926)
- Testing
- Probiotic Streptococcus salivarius K12, No probiotic supplementation
- Where
- Pakistan
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Haemophilia
Effectiveness of the uPatient Platform in Prophylactic Treatment in Hemophilia
Research project whose main objective is to evaluate the use of a technology platform (uPatient) to register the prophylactic treatment of patients with hemophilia treated in different Hematology and Hemotherapy services of…
- Trial name
- uPatient (NCT02581735)
- Testing
- Patients with haemophilia
- Volunteers
- 40 people
- Sponsor
- Real Fundación Victoria Eugenia
Postpartum Hemorrhage
Effect of Prophylactic Administration of Oxytocin in Uniject™ on Postpartum Hemorrhage at Home Births in Ghana
This study is designed to test the hypothesis that the intramuscular administration of 10 IU of oxytocin in Uniject™ during the third stage of labor by a Community Health Officer (CHO) at home births in Ghana will reduce the risk…
- Trial name
- NCT01108289
- Testing
- Oxytocin in Uniject
- Where
- Ghana
- Volunteers
- 1,586 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Thrombotic Thrombocytopenic Purpura (TTP)
A Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic thrombocytopenic purpura (or TTP for short) is a condition where blood clots form in small blood vessels throughout the body.
- Trial name
- NCT03393975
- Testing
- TAK-755, Standard of care
- Where
- 33 sites in United States, Austria and 7 more
- Volunteers
- 52 people
- Sponsor
- Baxalta now part of Shire