Clinical trials: Prophylactic
Hemophilia A Patient
Efanesoctocog Prophylaxis Or The Optimization Of Treatment: Real-World Experience Of Taylorizing Clotting Therapy In Hemophilia A
Prophylactic management of severe Hemophilia A (HA) without inhibitors has historically relied on frequent intravenous infusions of standard or EHL FVIII concentrates or on subcutaneous emicizumab administered weekly to monthly…
- Trial name
- E-PROTECT (NCT07830693)
- Testing
- Study questionnaires, Clinical/pharmacological data collection
- Where
- 8 sites in France
- Volunteers
- 553 people
- Sponsor
- Nantes University Hospital
Malaria, Falciparum, Anemia
The Community Effectiveness of IPTi in Southern Tanzania
The safety and efficacy of Intermittent Preventive Treatment for malaria and anaemia control in Infants (IPTi) have already been documented in Southern Tanzania, affording an opportunity to gain operational experience in…
- Trial name
- NCT00152204
- Testing
- Sulfadoxine-pyrimethamine used for IPTi, IPTi
- Where
- Tanzania
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Child, Parents
The VIA Family 2.0 - a Family Based Intervention for Families with Parental Mental Illness
VIA Family 2.0 - a Family Based Intervention for families with parental mental illness Background: Children born to parents with mental illness have consistently been shown to have increased risks for a range of negative life…
- Conditions
- Child, Parents, Mental Disorder, Child of Impaired Parents
- Trial name
- NCT06312410
- Testing
- VIA Family 2.0
- Where
- Denmark
- Volunteers
- 1,452 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Autistic Disorder, Dental Caries
Effectiveness of Sealants and Fluoride Varnish in Caries Prevention in Children With Autism Spectrum Disorders
The aim of the study is to compare application of sealants together with fluoride varnishes versus only fluoride varnishes in preventing caries lesions development in the occlusal surface of first permanent molars of children…
- Conditions
- Autistic Disorder, Dental Caries, Pit and Fissure Caries
- Trial name
- NCT05146479
- Testing
- Fluoride varnish and pit and fissure sealants onto first permanent molars
- Where
- Italy
- Volunteers
- 232 people
- Sponsor
- University of Milan
Malaria in Pregnancy
Evaluating the Effects of Community Delivery of Malaria Intermittent Preventive Treatment on Pregnant Women and Babies
This study evaluates the effectiveness of community delivery of sulfadoxine-pyrimetamine (SP) for intermittent preventive treatment of malaria in pregnancy (IPTp) in increasing the coverage of IPTp among pregnant women in…
- Trial name
- TIPTOP (NCT03600844)
- Testing
- Community distribution of SP for IPTp
- Where
- 12 sites in Democratic Republic of the Congo, Madagascar and 2 more
- Volunteers
- 10,602 people, healthy volunteers welcome
- Sponsor
- Jhpiego
Cerebrovascular Accident, Transient Ischemic Attack
The Post Stroke Preventive Trial (PREVENT). A RCT Nested in a Cohort Study
Patients with a diagnosis of stroke or TIA, who are already included in the RIALTO-cohort study are asked to participate in a RCT after discharge from hospital.
- Conditions
- Cerebrovascular Accident, Transient Ischemic Attack, Myocardial Infarction
- Trial name
- PREVENT (NCT00253097)
- Testing
- Intervention
- Where
- 2 sites in Denmark
- Volunteers
- 353 people
- Sponsor
- Hvidovre University Hospital
Cardiovascular Disease
Preventive Health Practices in Women
The purpose of this study is to evaluate women's level of knowledge and health practices regarding cardiovascular health and identify barriers to appropriate health practice.
- Trial name
- NCT00724399
- Testing
- Survey on womens health Issues.
- Where
- United States
- Volunteers
- 1,418 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Apnea
Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity
Investigators hypothesized that the timing of caffeine administration in either prophylaxis or treatment of apnea of prematurity will affect the apnea response to caffeine
- Trial name
- NCT02677584
- Testing
- Prophylactic caffeine citrate, Therapeutic caffeine citrate
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Mansoura University Children Hospital
Emotional Distress, Functional Impairment
Evaluation of Three School-based Mental Health Preventive Interventions in France
To meet adolescents' needs regarding mental health vulnerability, this study aims to propose and evaluate three original school-based preventive interventions delivered to French 13y-adolescents, with respect to their effects on…
- Conditions
- Emotional Distress, Functional Impairment, Psychosocial Problem, Wellbeing
- Trial name
- NCT06059092
- Testing
- Adapt Module, Engage Module, Interact Module
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Nimes
Emergence Delirium
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Fifty children undergoing heart catheterization without local anesthesia in the skin will be randomly divided into two groups. Group DM (Dexmedetomidine + Midazolam) and Group KM (Ketamine + Midazolam)
- Trial name
- NCT07427446
- Testing
- Dexmedetomidine and Midazolam, Ketamine and Midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Diabetes
Novel Type 2 Diabetes Mellitus Preventive Therapies
Over the past two decades, type 2 diabetes mellitus (T2DM) has emerged from relative obscurity to become one of the most serious complications of obesity in Hispanic obese populations, especially among those with a family history…
- Trial name
- NCT02351323
- Testing
- Glutamine (Pharmacological doses), Lifestyle change
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Medical Center
Low Cardiac Output Syndrome, Cardiac Surgical Procedures
Prophylactic Use of Milrinone After Congenital Heart Surgery in Infants
This randomized, multi-center, double-blinded, placebo-controlled study is designed to evaluate the efficacy and safety of milrinone compared with placebo in participants after corrective surgery for congenital heart disease.
- Conditions
- Low Cardiac Output Syndrome, Cardiac Surgical Procedures, Infant
- Trial name
- NCT03823781
- Testing
- Milrinone, Normal saline
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Shanghai Children's Medical Center
Myalgia
Diosmin for Treatment of Delayed-onset Muscle Soreness (DOMS)
The potential benefits of exercise for the treatment of chronic inflammatory diseases and pain have been well documented in the scientific literature.
- Trial name
- UEL (NCT06125002)
- Testing
- Diosmin750
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sergio Marques Borghi
Non Hodgkin's Lymphoma, Hepatitis B
Prophylactic Use of Entecavir for Non-Hodgkin's Lymphoma Patients With Resolved Hepatitis B
Hepatitis B (HBV) reactivation and hepatitis flare induced by cytotoxic chemotherapy is common in cancer patients who have chronic HBV infection.
- Trial name
- HBVNHL (NCT00926757)
- Testing
- Entecavir prophylaxis, Therapeutic entecavir
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Preventive Care, Medication Management
Conversational IT for Better, Safer Pediatric Primary Care
Interactive telephony technologies offer a potentially highly effective, patient-centered communication modality by guiding parents at home through interactive discussions that can gather information and actively reinforce…
- Trial name
- PHP (NCT01188629)
- Testing
- Safety Training, Personal Health Partner and Counseling (PHP+C)
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- Boston Medical Center
Autism Spectrum Disorder
An SRT Model for Early Access to ASD Intervention
This project will implement and evaluate an innovative healthcare service delivery model designed to promote earlier access to specialized intervention for toddlers with ASD.
- Trial name
- NCT02409303
- Testing
- Screen-Refer-Treat Intervention
- Where
- United States
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Washington
Preventive Health Services (PREV HEALTH SERV)
A Vaccine Communication Training Intervention for Pediatric Inpatient Clinicians
This study will examine a novel stakeholder-informed intervention to identify vaccine-eligible children and promote evidence-based clinician vaccine communication with families with the goal of increasing vaccine uptake during…
- Trial name
- PIVOT-IN (NCT07552857)
- Testing
- PIVOT-IN, Standardized Vaccine Eligibility Screening
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital
Hereditary Angioedema Types I and II
A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema
The aim of this study is to assess the efficacy of C1-esterase inhibitor in preventing hereditary angioedema attacks when it is administered under the skin of subjects with hereditary angioedema.
- Trial name
- NCT01912456
- Testing
- Low-volume C1-esterase inhibitor, Higher-volume C1-esterase inhibitor
- Where
- 39 sites in United States, Australia and 8 more
- Volunteers
- 90 people
- Sponsor
- CSL Behring
Cardiovascular Disease
Does Prophylactic Coronary Artery Revascularization for High Risk Patients Reduce Long-term Risk of Mortality
Although a number of sophisticated diagnostic tests have been shown to be helpful in identifying patients at high risk for perioperative cardiac complications, no study has addressed the most important question: Should…
- Trial name
- CARP (NCT00032370)
- Testing
- Vascular surgery with best medical treatment, Coronary artery bypass grafting (CABG), Percutaneous transluminal coronary angioplasty (PTCA)
- Where
- 18 sites in United States
- Volunteers
- 510 people
- Sponsor
- US Department of Veterans Affairs
Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder
Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
A subgroup of patients with childhood-onset obsessive-compulsive disorder (OCD) and/or tic disorders has been identified who share a common clinical course characterized by dramatic onset and symptom exacerbations following group…
- Conditions
- Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder, Streptococcal Infection, Tic Disorder
- Trial name
- NCT00001359
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)