Clinical trials: Prophylactic
Anemia
Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire
The proposed project is aimed at testing two interventions, namely a highly bioavailable iron compound and a combination of SP plus amodiaquine for intermittent preventive treatment (IPT) of malaria, to reduce anaemia in very…
- Trial name
- NCT01634945
- Testing
- SP/amodiaquine, FeFum fortified porridge, SP/Amodiaquine + FeFum fortified porridge
- Where
- Côte d’Ivoire
- Volunteers
- 629 people
- Sponsor
- Swiss Federal Institute of Technology
Violence
A Randomized Controlled Trial of Miles de Manos (Thousands of Hands)
Violence is one of the leading causes of death for young people and has widespread costs for individuals, families and communities.
- Trial name
- MdM (NCT05932056)
- Testing
- Miles de Manos (Thousands of Hands)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Texas at Austin
Breast Cancer
Does a Preoperative Prophylactic Antibiotic Reduce Surgical Site Infection Following Wire-localized Lumpectomy
Background: Data on the benefits of preoperative prophylactic antibiotics for breast surgery are conflicting and there is no guideline for their use for wire-localized lumpectomy.
- Trial name
- NCT04818931
- Testing
- Cefazolin Injection
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- CHU de Quebec-Universite Laval
Genetic Predisposition to Disease, Hereditary Diseases
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks.
- Trial name
- NCT05161169
- Testing
- Genome Sequencing
- Where
- 3 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pediatric Obesity, Preventive Medicine
Patient-Clinic-Community Integration to Prevent Obesity Among Rural Preschool Children
The goal of this research study is to compare two enhancements to well-child visits at Geisinger designed to promote family-centered counseling for the prevention of obesity in a high-risk population of rural, lower income…
- Conditions
- Pediatric Obesity, Preventive Medicine, Mentoring, Food Supply
- Trial name
- ENCIRCLE (NCT04406441)
- Testing
- Patient Reported Outcome Well Child Visit, Patient Reported Outcome Well Child Visit + Food Care
- Where
- United States
- Volunteers
- 2,040 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Child Rearing, Adolescent Development
Follow-up of Families in Early Preventive Intervention
This project supports the post-third-grade assessment of 693 children and their families who were enrolled in a randomized trial of a program of prenatal and infancy home visitation by nurses that was epidemiologically and…
- Conditions
- Child Rearing, Adolescent Development, Reproductive Behavior, Risk Reduction Behavior
- Trial name
- MemphisYear9 (NCT00438516)
- Testing
- nurse home visitation
- Where
- United States
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Malaria
Efficacy of Amodiaquine-artesunate in Children Aged 6-59 Months With Uncomplicated P. Falciparum Malaria
We will be studying the clinical efficacy of amodiaquine-artesunate currently being studied in an intermittent preventive therapy in infants (IPTi)trial in the same area in order to correlate preventive efficacy seen in IPTi with…
- Trial name
- IPTi DRWG (NCT00425763)
- Testing
- AQAS
- Where
- Kenya
- Volunteers
- 110 people
- Sponsor
- Centers for Disease Control and Prevention
Well Child Preventive Care
Can Parental Activation Over the Internet Improve Pediatric Preventive Care?
This study is a randomized controlled trial of an evidence based, patient specific web site's ability to improve preventive practices in pediatric care.
- Trial name
- NCT00101855
- Testing
- An evidence based tailored web site
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Hemophilia A
A Trial Investigating Safety and Efficacy of Treatment With BAY94-9027 in Severe Hemophilia A
Haemophilia A is an inherited disorder in which one of the proteins, Factor VIII, needed to form blood clots is missing or not present in sufficient levels.
- Trial name
- PROTECT-VIII (NCT01580293)
- Testing
- BAY94-9027
- Where
- 59 sites in United States, Austria and 18 more
- Volunteers
- 145 people
- Sponsor
- Bayer
Upper Respiratory Tract Infection
Probiotic S. Salivarius K12 for the Prevention of Upper Respiratory Tract Infection in Nursery-age Children
The purpose of this retrospective study is to assess the treatment benefits of probiotic Streptococcus salivarius K12 for the prevention of recurrent bacterial and viral infections of the pharynx, tonsils and ears in children…
- Trial name
- PUNK (NCT05840926)
- Testing
- Probiotic Streptococcus salivarius K12, No probiotic supplementation
- Where
- Pakistan
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Postpartum Health, Breastfeeding
Navigating New Motherhood 2
The primary aim of this study is to determine whether implementation of a postpartum patient navigation program improves health outcomes among low-income women.
- Conditions
- Postpartum Health, Breastfeeding, Contraception, Preventive Care / Anticipatory Guidance
- Trial name
- NNM2 (NCT03922334)
- Testing
- Patient Navigation Program
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hereditary Angioedema
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
The study objective was to evaluate the safety and efficacy of prophylactic use of C1INH-nf for the prevention of acute HAE attacks.
- Trial name
- CHANGE 3 (NCT00462709)
- Testing
- C1 esterase inhibitor [human] (C1INH-nf)
- Where
- 48 sites in United States
- Volunteers
- 146 people
- Sponsor
- Shire
Myeloid Leukemia
A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups
The purpose of this study is to show that a therapeutic platelet transfusion strategy (i.e. platelet transfusion only in case of bleeding) needs minimally a quarter less of transfusions compared to the standard prophylactic…
- Trial name
- NCT00521664
- Testing
- Prophylactic platelet transfusion, Therapeutic platelet transfusion
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technische Universität Dresden
Mother to Child HIV Transmission
HIV Diagnosis and Treatment at Birth for Newborn With High Risk HIV Exposure
Principal objective Assess the operational efficacy of a strategy combining early diagnosis and preventive antiretroviral treatment systematically reinforced from the birth* among infants at high risk of infection with HIV** .
- Trial name
- DIAVINA (NCT03642704)
- Testing
- Reinforced preventive ARV therapy
- Where
- Guinea
- Volunteers
- 56 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Patent Ductus Arteriosus in Preterm Infants, Patent Ductus Arteriosus After Premature Birth
Prophylactic IV Paracetamol in Extremely Premature Infants
Purpose of the research Everyone is born with an opening between the chambers of the heart, called a ductus arteriosus. In most people, it closes on its own, but in infants born at less than 30 weeks or less than 1250 grams…
- Conditions
- Patent Ductus Arteriosus in Preterm Infants, Patent Ductus Arteriosus After Premature Birth, Patent Ductus Arteriosus (PDA), Patent Ductus Arteriosus in Premature Infants
- Trial name
- NCT07067177
- Testing
- Paracetamol (drug)
- Where
- 3 sites in Palestinian Territories
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Quds University
Malaria in Pregnancy
Intermittent Preventive Treatment With Dihydroartemisinin-piperaquine in Papua, Indonesia
Malaria in pregnancy is a major cause of maternal and neonatal death in Papua, Indonesia. A recent trial in Papua showed that monthly intermittent preventive treatment (IPTp) with the long-acting artemisinin-based combination…
- Trial name
- STOPMiP-2 (NCT05294406)
- Testing
- Intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine
- Where
- Indonesia
- Volunteers
- 2,128 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Covid19
COVID 19 Preventive Measures Among Mansoura Nursing Students
This study aims to identify nursing students knowledge gaps, risk perceptions and adherence to COVID 19 preventive measures during written exam period and In addition due to the possibility of being infected with COVID-19 during…
- Trial name
- NCT04473547
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Mansoura University
Infection, Oxygen Saturation
Comparison of Oxygen Saturation Measurements Using Different Glove Colors in Children
The aim of this study was to determine the effect of different colored gloves on oxygen saturation in pediatric patients whose oxygen saturation was measured by pulse oximetry in pediatric emergency department.
- Conditions
- Infection, Oxygen Saturation, Children
- Trial name
- NCT06626763
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Hereditary Angioedema
CSL312 (Garadacimab) in the Prevention of Hereditary Angioedema Attacks
This is a multicenter, double-blind, randomized, placebo-controlled, parallel-arm study to investigate the efficacy and safety of subcutaneous administration of CSL312 (garadacimab) in the prophylactic treatment of hereditary…
- Trial name
- NCT04656418
- Testing
- CSL312
- Where
- 28 sites in United States, Canada and 5 more
- Volunteers
- 64 people
- Sponsor
- CSL Behring
Caesarean
Prophylactic Ceftizoxime (Cefizox) for Elective Cesarean Delivery
Ceftizoxime (Cefizox) will reduce post Cesarean delivery febrile morbidity.
- Trial name
- NCT01347593
- Testing
- ceftizoxime
- Where
- Sudan
- Volunteers
- 220 people
- Sponsor
- University of Khartoum