Clinical trials: Prophylactic
Depression
A Trial of a Preventive Intervention Program for Chilean Families With Depressed Parents
The overall aim of this pilot study is to evaluate the acceptability and feasibility of an adaptation of Beardslee's 'Preventive Intervention Program (PIP) for Depression' in Chilean families.
- Trial name
- FamilyTalkCL (NCT02593266)
- Testing
- Preventive Intervention Program (PIP) for depression
- Where
- Chile
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Chile
Death, Nosocomial Infection
Prophylactic Probiotics in Premature Infants
This study tries to determine whether the oral administration of a specific probiotic (good bacteria) in premature infants hospitalized in a neonatal intensive care unit may prevent infections and the development of a severe…
- Trial name
- C3P (NCT00727363)
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Colombia
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Colombian Neonatal Research Network
HIV Infections, Pregnancy Complications, Infectious
Prenatal and Postnatal Studies of Interventions for Prevention of Mother-To-Child Transmission
The purpose of this study is to collect and study clinical and laboratory information about a pregnant or new mother and her medical care that will increase our knowledge of the best care for HIV-infected pregnant women and their…
- Trial name
- NCT00028145
- Testing
- Adherence assessment
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 3,090 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Postpartum Depression, Child Development
Prenatal Depression Prevention Effects on Parenting and Young Child Self-Regulation and Functioning
Poor parenting practices and compromised child self-regulation when a child is 2 ½ - 4 ½ years old are foundational in promoting their later healthy development and adaptive functioning.
- Conditions
- Postpartum Depression, Child Development, Parenting, Child Self-Regulation
- Trial name
- EPIC (NCT04296734)
- Testing
- Mothers and Babies
- Where
- United States
- Volunteers
- 960 people
- Sponsor
- Northwestern University
Myeloid Leukemia
A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups
The purpose of this study is to show that a therapeutic platelet transfusion strategy (i.e. platelet transfusion only in case of bleeding) needs minimally a quarter less of transfusions compared to the standard prophylactic…
- Trial name
- NCT00521664
- Testing
- Prophylactic platelet transfusion, Therapeutic platelet transfusion
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technische Universität Dresden
Mutation
C677T Methylenetetrahydrofolate Reductase Mutation
To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation.
- Trial name
- C677T (NCT05864937)
- Testing
- infertily evaluation
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fluorides, Dental Caries
Preventive Effect of Salt Fluoridation
This was a block-randomized, controlled, open-label trial and was executed in two preschools in The Gambia. Fluoridated table salt (250 mg F/kg salt) was administered in daily communal preschool feeding.
- Trial name
- NCT02585882
- Testing
- Fluoride table salt
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
HIV Infections, HIV Seronegativity
A Study of the Effects of Giving Two Anti-HIV Vaccines to Babies of HIV-Positive Mothers
The purpose of this study is to see if giving the ALVAC vCP1452 anti-HIV vaccine alone or with another vaccine called AIDSVAX B/B to babies of HIV-positive mothers is safe.
- Trial name
- NCT00000879
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), MN rgp120/HIV-1 and GNE8 rgp120/HIV-1, ALVAC-HIV MN120TMG (vCP205)
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Neonatal Sepsis, Early-Onset, Very Low Birth Weight Infant
IgM-Enriched Immunoglobulin for Neonatal Sepsis
This study compares giving prophylactic IgM enriched Intravenous Immunoglobulin (IVIG) with placebo in 1 hour after birth, in neonates with risk factors of Early-Onset Neonatal Sepsis (EONS).
- Conditions
- Neonatal Sepsis, Early-Onset, Very Low Birth Weight Infant, Inflammation, Infant, Newborn, Disease
- Trial name
- NCT04041765
- Testing
- IgM-enriched IVIG
- Volunteers
- 70 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Migraine
A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age
The primary objective of the study is to evaluate the effectiveness of fremanezumab as compared to placebo for the preventive treatment of chronic migraine (CM).
- Trial name
- NCT04464707
- Testing
- Fremanezumab
- Where
- 89 sites in United States, Canada and 7 more
- Volunteers
- 292 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Children With Typical Development
OUT to IN: an Outdoor Body-oriented Intervention Program
The goal of this randomized trial is to examine the effects of a body-oriented intervention program on preschoolers' social-emotional competence.
- Trial name
- NCT05756374
- Testing
- OUT to IN
- Where
- Portugal
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Évora
Child Abuse
Preventing Child Abuse in Infants
The purpose of this study is to compare 2 approaches (interventions) to prevent child-abuse (maltreatment) in infants: Psychoeducational Home Visitation (PHV) vs Infant-Parent Psychotherapy (IPP).
- Trial name
- NCT00000382
- Testing
- Infant-Parent Psychotherapy, Child Protective Services, Psychoeducational Home Visitation
- Sponsor
- University of Rochester
Malaria,Falciparum, Anemia
Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania
Background: In high-transmission settings, up to 70% of school-aged children harbour malaria parasites which is mostly asymptomatic, thus, from an epidemiological point of view, they contribute significantly as reservoir to…
- Trial name
- InSMART-school (NCT03640403)
- Testing
- Dihydroartemisinin-piperaquine, Artesunate-amodiaquine
- Where
- Tanzania
- Volunteers
- 1,555 people, healthy volunteers welcome
- Sponsor
- National Institute for Medical Research, Tanzania
Haploidentical Hematopoietic Stem Cell Transplantation
Effect of NAC on the Hematopoietic Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation
The aim of the study is to evaluate the efficacy of the prophylactic administration of N-acetyl-L-cysteine (NAC) in acute leukemia patients with complete remission pre- and post-allotransplant on the occurrence of poor graft…
- Trial name
- NCT03236220
- Testing
- N-acetyl-L-cysteine
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Postoperative Vomiting
Postoperative Vomiting in Children - Is Dextrose an Effective Prophylactic Anti-emetic?
The aim of this study was to investigate the efficacy of intraoperative intravenous dextrose in preventing POV in pediatric population undergoing dental day surgery.
- Trial name
- DEXPO (NCT01912807)
- Testing
- Dextrose (D5NS), Ondansetron (Control)
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of Saskatchewan
Cardiovascular Disease
Preventive Health Practices in Women
The purpose of this study is to evaluate women's level of knowledge and health practices regarding cardiovascular health and identify barriers to appropriate health practice.
- Trial name
- NCT00724399
- Testing
- Survey on womens health Issues.
- Where
- United States
- Volunteers
- 1,418 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Surgery, COVID
Surgery During Covid-19: The Role of Asymptomatic Patients, a Survey
a brief questionnaire to get a clearer picture of the situation regarding surgical patients with special emphasis on asymptomatic Covid-19 patients.
- Conditions
- Surgery, COVID, Asymptomatic Patient, Covid-19
- Trial name
- NCT04344197
- Testing
- global survey
- Where
- Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata
HIV Infections
Extended Follow-Up of Participants in Preventive HIV Vaccine Studies in Uganda
Two previous studies of an HIV preventive vaccine, the STEP study and the Phambili study, were halted because people who received the vaccine were more likely to become infected with HIV.
- Trial name
- NCT01109342
- Where
- Uganda
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sports Injury
Effectiveness and Process Evaluation of the Injury-preventive Program #Utviklingsklar
The majority of injuries among Norwegian youth occur in sports. The purpose of the project is to conduct an effect and process evaluation of the intervention #Utviklingsklar, an injury-preventive club-based intervention in youth…
- Trial name
- NCT06486090
- Testing
- #Utviklingsklar
- Where
- 6 sites in Norway
- Volunteers
- 2,954 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences