Clinical trials: Prophylaxis
HIV/AIDS, HSV-2 Infection
The Impact of VCT and Condom Distribution as HIV Prevention Strategies Among Youth in Kenya
The vast majority of new HIV infections occur in sub-Saharan Africa, where nearly 2 million people become infected with HIV/AIDS every year.
- Trial name
- NCT03868644
- Testing
- Voluntary Counseling and Testing for HIV (VCT), Condoms
- Volunteers
- 10,646 people
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Cytomegalovirus Retinitis, HIV Infections
The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV
To evaluate the safety and efficacy of oral ganciclovir for prophylaxis against cytomegalovirus (CMV) retinal and gastrointestinal mucosal disease in HIV-infected patients with severe immunosuppression.
- Conditions
- Cytomegalovirus Retinitis, HIV Infections, Gastrointestinal Diseases
- Trial name
- NCT00001034
- Testing
- Ganciclovir
- Where
- 17 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Childhood Obesity, Overweight and Obesity
Childhood Obesity - Prevention of Diabetes Through Changed Eating Patterns
The main purpose of the present study is to perform a 10 weeks dietary intervention study with a follow-up for 52 weeks in children from 7-14 years of age with overweight or obesity.
- Conditions
- Childhood Obesity, Overweight and Obesity, Adolescent Obesity, Adolescent Overweight
- Trial name
- COPE (NCT04522921)
- Testing
- Diet with a higher amount of protein (25E% per day), Increased follow-up contact after the 10-week intervention, Diet with a lower amount of protein (15E% per day)
- Where
- 2 sites in Denmark
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hemophilia A
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors
This multicenter, open-label study will evaluate the safety, efficacy and pharmacokinetics of prophylactic emicizumab treatment in participants previously treated with episodic or prophylactic bypassing agents.
- Trial name
- HAVEN 1 (NCT02622321)
- Testing
- Emicizumab, rFVIIa, aPCC
- Where
- 44 sites in United States, Australia and 12 more
- Volunteers
- 113 people
- Sponsor
- Hoffmann-La Roche
Cyberbullying, Grooming
Wise Interventions in the Digital Society
This study evaluates the effectiveness of a Wise intervention based on self-affirmation (SA) and Implicit Theories of Personality (ITP) in Spanish adolescents and young people.
- Conditions
- Cyberbullying, Grooming, Risk Behavior
- Trial name
- NCT04497506
- Testing
- Wise Intervention (Self-affirmation and Incremental theory of personality), Standard preventive intervention
- Where
- Spain
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- University of Deusto
Congenital Bleeding Disorder, Haemophilia A With Inhibitors
Efficacy of NovoSeven® in Bleeding Prophylaxis in Hemophilia
This trial is conducted in Africa, Asia, Europe, South America, and the United States of America (USA). The purpose of this study is to evaluate the effectiveness of secondary prophylactic treatment with NovoSeven® in haemophilia…
- Conditions
- Congenital Bleeding Disorder, Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
- Trial name
- NCT00108758
- Testing
- activated recombinant human factor VII
- Where
- 37 sites in United States, Argentina and 10 more
- Volunteers
- 23 people
- Sponsor
- Novo Nordisk A/S
Pneumonia, Pneumocystis Carinii, HIV Infections
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4 lymphocytes per mm3.
- Trial name
- NCT00002043
- Testing
- Dapsone
- Where
- United States
- Sponsor
- Jacobus Pharmaceutical
Behavior, Adolescent, Childhood Obesity
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
The aim of this study is to look at changes in diabetes-related risk factors in Black adolescent girls who are at risk for type 2 diabetes and their primary female caregiver after both participating in a 12-week in-person…
- Conditions
- Behavior, Adolescent, Childhood Obesity, Diabetes Mellitus, Type 2, Pediatric Obesity
- Trial name
- BGW In-Person (NCT06557317)
- Testing
- Black Girls for Wellness In-Person
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cornell University
Gliosis, Child Obesity
Building Research for Intervention Development in Gliosis and Eating Habits
The goal of this study is to 1) use magnetic resonance imaging (MRI) to evaluate the effect of nutritious foods on inflammation in the human hypothalamus of children and 2) assess the feasibility and acceptability of nutritious…
- Conditions
- Gliosis, Child Obesity, Eating
- Trial name
- BRIDGE (NCT06870578)
- Testing
- Diet modification
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Washington
Atopic Dermatitis, Type 1 Hypersensitivity
Allergic Disease Onset Prevention Study
This is a Phase 1b/2, randomized, double-blind, multi-center study to evaluate the safety, tolerability, and preliminary clinical efficacy of STMC-103H in neonates and infants at risk for developing allergic disease (Type 1…
- Trial name
- adored (NCT05003804)
- Testing
- STMC-103H
- Where
- 31 sites in United States, Australia and 1 more
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Siolta Therapeutics, Inc.
Myopia
Early Intervention for High Risk Premyopic Children
The purpose of this research project is to add evidence of pharmacological (0.025% atropine) and optical (Defocus Integrated Multiple Segments Triple Enhanced Design spectacle lenses ) approaches for myopia prevention among…
- Trial name
- NCT07863713
- Testing
- 0.025% atropine eye drops, DIMS TED
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Teen Pregnancy, Pregnancy in Adolescence
Future Foundation 2.0 Personal Responsibility Education Innovative Strategies (PREIS) Program
This study uses a randomized controlled trial (RCT) design to evaluate the impacts of the Future Foundation (FF) 2.0 Personal Responsibility Education Innovative Strategies (PREIS) program on reducing students' sexual activity…
- Conditions
- Teen Pregnancy, Pregnancy in Adolescence, Teen Pregnancy Prevention, Pregnancy Prevention
- Trial name
- NCT03729726
- Testing
- Future Foundation 2.0 PREIS Program
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Metis Associates, Inc.
Influenza, Respiratory Viral Infection
Test-and-treat for Influenza in Homeless Shelters
This study is a stepped-wedge cluster-randomized trial of on-site rapid testing and treatment for influenza in homeless shelters within the Seattle area to determine whether this strategy reduced the incidence of influenza in the…
- Trial name
- NCT04141917
- Testing
- Point-of-care molecular testing and treatment of influenza
- Where
- 9 sites in United States
- Volunteers
- 1,618 people
- Sponsor
- University of Washington
Suicide Ideation
Psychological Capital and Suicide Ideation
This study examined whether developing Psychological Capital (PsyCap) could help reduce suicidal thoughts among high school students in Guyana.
- Trial name
- NCT07839117
- Testing
- Psychological Capital (PsyCap) Development Intervention
- Where
- Guyana
- Volunteers
- 3,231 people, healthy volunteers welcome
- Sponsor
- Bellevue University
Malaria, HIV Infections
HIV Protease Inhibitors for the Prevention of Malaria in Ugandan Children
HIV and malaria are major causes of morbidity and mortality in Sub-Saharan Africa and children bear the greatest brunt of both diseases. No single existing intervention is likely to control malaria in Africa.
- Trial name
- PROMOTE-PEDS (NCT00978068)
- Testing
- Lopinavir/Ritonavir (LPV/r), Nevirapine (NVP), Efavirenz (EFV)
- Where
- Uganda
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria (Plasmodium Falciparum), Malaria Incidence
Insecticide-Treated Baby Wraps for the Prevention of Malaria
The objective is to test the protective effect of permethrin-treated and etofenprox-treated lesus against malaria in young children
- Trial name
- NCT07773350
- Testing
- Permethrin-treated lesu, Etofenprox-treated lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Caries,Dental
Fluoride Caries-control Effectiveness/Feasibility in Children
The aim of this study is to compare the effectiveness and feasibility of using silver diamine fluoride solution (SDF) vs. sodium fluoride varnish (NaF) for caries management in children from Bogotá (and its suburban areas) and…
- Trial name
- NCT06690008
- Testing
- Experimental group
- Where
- 2 sites in Colombia
- Volunteers
- 814 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Liver Cirrhosis
Probiotics for the Prevention of Major Complications of Cirrhosis
The purpose of this study is to determine whether probiotics are effective in the prevention of the complications of liver cirrhosis.
- Trial name
- NCT00312910
- Testing
- Probiotics-Bio-plus
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
HIV Prevention
Safety and Acceptability Study of PrePex Device When Removing the Foreskin Shortly After Placement of Device
To assess the safety and acceptability of the non-surgical PrePex device among healthy adult male participants scheduled for voluntary medical male circumcision when removing the foreskin shortly after device placement.
- Trial name
- NCT03132285
- Testing
- PrePex
- Where
- 2 sites in Zambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Zambia
Dengue
Insecticidal School Uniforms for Dengue Prevention in Thailand
This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years.
- Trial name
- DengueTools (NCT01563640)
- Testing
- permethrin insecticide, washing
- Where
- Thailand
- Volunteers
- 1,825 people, healthy volunteers welcome
- Sponsor
- Umeå University
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