Clinical trials: Prophylaxis
Substance Use
A Family-Centered Ojibwe Substance Abuse Prevention
This study will complete a multisite randomized controlled trial (RCT) of a family-centered alcohol and drug prevention program for Anishinabe (Ojibwe) pre-adolescents in 3rd or 4th grade (Fall 2017) or who are age 8-10 years on…
- Trial name
- BZDDD (NCT02700035)
- Testing
- Bii-Zin-Da-De-Dah (Listening to One Another)
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Tobacco Smoking Behavior
Teens Against Tobacco Use: A Model for Universal Tobacco Prevention and Youth Advocacy
This study evaluates the efficacy of Teens Against Tobacco Use anti-tobacco presentations on tobacco use susceptibility in 4th-8th grade.
- Trial name
- TATU (NCT02443025)
- Testing
- Teens Against Tobacco Use
- Where
- United States
- Volunteers
- 2,414 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Spontaneous Bacterial Peritonitis
Norfloxacin With Itopride Versus Norfloxacin in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis
Norfloxacin versus Norfloxacin with Itopride in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis
- Trial name
- NCT04161768
- Testing
- Norfloxacin, Itopride
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Depressive Symptoms, Allostatic Load
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States.
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- R&T (NCT07554326)
- Testing
- Rise Together: Community Engagement Intervention, Adulting 101: Life Skills
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Preterm Birth, Pregnancy Trimester, Second
Progesterone for Prevention of Preterm Birth in Women With Short Cervix: Randomized Controlled Trial
The aim of our study is to evaluate the effect of use of prophylactic vaginal progesterone on the incidence of severe preterm delivery, defined as delivery before 33+6 weeks in women with a short cervical length of 15mm.
- Trial name
- NCT00422526
- Testing
- Micronised progesterone (Utrogestan)
- Where
- 8 sites in Brazil, Chile and 2 more
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Smoking
Evaluation of a School-based Smoking Prevention and Cessation Programme in Negeri Sembilan
School-based smoking cessation programmes stretched longer than a year had 12% reduction in preventing smoking uptake. With regards to smoking intervention programme among adolescents, there is a lack of evidences regarding its…
- Trial name
- NCT04378725
- Testing
- School-based smoking prevention and cessation program (The KOTAK program)
- Where
- Malaysia
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Coping, Stress Disorders, Post-Traumatic
D-Stress Baltimore: School-based Mindfulness Instruction
Effective strategies to ameliorate the negative effects of stressful urban living are greatly needed. D-Stress Baltimore (DSB) is an evidence-based mindfulness-based instructional program of stress-reduction techniques, found to…
- Conditions
- Coping, Stress Disorders, Post-Traumatic, Mental Health Wellness 1
- Trial name
- NCT02493218
- Testing
- Mindfulness Instruction, Health Education
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Blood Pressure
Preventing the Rise in Blood Pressure With Age Using Reduced-sodium Salt
The study is a small-scale, short-term unblinded feasibility study to explore the acceptability and feasibility of implementing a reduced-sodium iodised salt intervention in Nigeria.
- Trial name
- RAISED (NCT05912426)
- Testing
- Reduced-sodium potassium-enriched salt
- Where
- 2 sites in Nigeria
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- The George Institute
Childhood Obesity
YMCA-Physical Activity and Nutrition
There is an epidemic rise in the number of overweight and obese children. Overweight and obesity in children tracks into adulthood and carries elevated risk of chronic diseases such as seen with the metabolic syndrome (i.e.…
- Trial name
- YMCA-PAN (NCT01107678)
- Testing
- Healthy Snacks and Organized Physical Activity
- Where
- United States
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Healthy Participants
Prevention of Hazardous Use of Alcohol with Danish High School Students (Our Choice)
The trial 'Our Choice' examines the effect of two prevention interventions targeting school, parent, and student levels at Danish high schools.
- Trial name
- NCT06018389
- Testing
- Structural only, Structural+Group MI
- Where
- Denmark
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Parkinson Disease (PD)
Enhanced Tai Chi for Parkinson's Disease (Enhanced Tai Chi PD)
This pilot study evaluates whether a structured, Parkinson's disease-specific Tai Chi programme ("Enhanced Tai Chi") can improve motor and non-motor symptoms in people with Parkinson's disease (PD).
- Trial name
- ETC-PD (NCT07297368)
- Testing
- Enhanced Tai Chi (Enhanced-Tai-Chi-PD), Usual Treatment (Standard Clinical Care)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia
This phase III trial compares the effect of xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML).
- Trial name
- NCT07022678
- Testing
- Best Practice, Biospecimen Collection, Cytarabine
- Where
- 39 sites in United States
- Volunteers
- 556 people
- Sponsor
- Children's Oncology Group
Postoperative Vomiting
Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis
The purpose of this study is to evaluate the benefit of addition of droperidol to prophylaxis with ondansetron and dexamethasone in children with high risk of postoperative vomiting (POV).
- Trial name
- VPOP2 (NCT01739985)
- Testing
- Dexamethasone + ondansetron + Droperidol
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overweight, Obesity
School Nurse-directed Secondary Obesity Prevention for Elementary School Children
Primary Aim: To test the efficacy of an elementary school-based, school nurse-led weight management program to reduce excess weight gain among children, 8 to 12 years old who are overweight and at risk of overweight by increasing…
- Trial name
- NCT02029976
- Testing
- SNAPSHOT (Student, Nurses and Parents Seeking Healthy Options Together), Mailed monthly newsletters
- Where
- 3 sites in United States
- Volunteers
- 264 people
- Sponsor
- Temple University
Chemotherapy-Induced Nausea and Vomiting
Efficacy and Safety of Palonosetron Intravenous in Prevention of Chemotherapy Induced Nausea and Vomiting in Pediatric Patients
The primary objective is to evaluate the efficacy of two different doses of IV palonosetron in the prevention of chemotherapy induced nausea and vomiting in MEC and HEC patients through 120 hours after start of chemotherapy in…
- Trial name
- NCT01442376
- Testing
- Palonosetron, Ondansetron
- Where
- 67 sites in United States, Argentina and 14 more
- Volunteers
- 502 people
- Sponsor
- Helsinn Healthcare SA
Aggressive B-Cell Non-Hodgkin Lymphoma
A Study on Fractionated Rituximab to Avoid Lysis Syndrome in Aggressive B-Lymphoma
Tumour lysis syndrome (TLS) occurs as a consequence of the rapid destruction of malignant cells, spontaneously and/or in response to cytotoxic agents and immunotherapies.
- Trial name
- FRILLY (NCT05840289)
- Testing
- fractionated first dose rituximab
- Where
- Switzerland
- Volunteers
- 94 people
- Sponsor
- University Hospital, Geneva
Substance Use
Health and Resilience Projects: Foundations
The Health and Resilience Project (HARP): Foundations is investigating the efficacy of the Strong African American Families (SAAF) intervention in promoting the health and well being of African American adolescents.
- Trial name
- HARP-F (NCT05253235)
- Testing
- SAAF, Receipt of parenting book
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Child Abuse
A Dissemination Trial of the Positive Parenting Program to Reduce Child Maltreatment in South Carolina
This is a population-based evaluation of the effectiveness of the Triple-P-Positive Parenting Program. Triple-P is a system of parenting programs with multiple levels that aims to provide parents with parenting skills and support.
- Trial name
- NCT00164606
- Testing
- Positive Parenting Program (Triple-P)
- Where
- United States
- Volunteers
- 14,690 people
- Sponsor
- Centers for Disease Control and Prevention
Hepatitis B
Stop Hep B @ Birth
Single arm, prospective open-label study of a care model consisting of two components: Component I aims to achieve high coverage of interventions to prevent maternal-to-child transmission of hepatitis B virus: antenatal…
- Trial name
- NCT04998838
- Testing
- Tenofovir Disoproxil Fumarate 300 mg daily; HBV birth dose vaccine; hepatitis B immune globulin (HBIG), Regular Myanmar treatment
- Where
- Burma
- Volunteers
- 110 people
- Sponsor
- Myanmar Liver Foundation
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