Clinical trials: Prophylaxis
Work-related Injury
Effectiveness of a Distance Eduaction Course for Prevention in RSI/WRMD
Repetitive Strain Injuries (RSI) or Work-Related Ostomuscular Disorders (WRMD) are musculoskeletal disorders. Nursing is one of the categories of workers most affected, due to the inherent functions they perform in their daily…
- Trial name
- NCT03385954
- Testing
- Intervention, Control
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hematological Diseases, Thrombocytopenia
Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia
The purpose of this study is to evaluate the efficacy of ex vivo generated megakaryocytic progenitor cells (MPs) in prophylaxis and treatment of thrombocytopenia caused by chemotherapy in patients with acute leukemia (AL).
- Trial name
- NCT02241031
- Testing
- MPs, thrombopoietin (TPO) and interleukin-11
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hemophilia A
A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors
This is a randomized, global, multicenter, open-label, Phase 3 clinical study in participants with severe hemophilia A without inhibitors against Factor VIII (FVIII) who are 12 years or older.
- Trial name
- HAVEN 3 (NCT02847637)
- Testing
- Emicizumab, Factor VIII (FVIII)
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 152 people
- Sponsor
- Hoffmann-La Roche
Celiac Disease in Children
Celiac Disease Prevention With Probiotics
Background/Aim: Celiac disease is a common immune-mediated disorder, and the only currently available treatment is a gluten-free diet.
- Trial name
- CiPP (NCT03176095)
- Testing
- Probiotic
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Lund University
Teen Pregnancy Prevention
Evaluation of Unstained
The goal of this randomized trial is to learn if the Unstained intervention has a positive impact on the sexual health behaviors of sexually active youth between the ages of 14 and 22 years old who are at risk for or involved in…
- Trial name
- NCT06574139
- Testing
- Unstained, Like
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The Policy & Research Group
Blood Transfusion, Cytomegalovirus Infections
Transfusion-Transmitted Cytomegalovirus Prevention in Neonates
To evaluate the capacity of intravenously administered cytomegalovirus (CMV)-immune globin (CMVIG) to immunize high risk premature infants against CMV infections.
- Trial name
- NCT00000584
- Testing
- immunoglobulins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity
Randomized, Controlled, Open, Comparative Intervention Study for Obesity Prevention in Children
Randomized, controlled, open, comparative intervention study in 270 children at risk for obesity.Patients will be randomly allocated into one of two behavior intervention groups or control group in ratio of 1:1:1.The study will…
- Trial name
- 4055obesityprv (NCT00438555)
- Testing
- Parents and children group, Parent's group
- Where
- Israel
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
HIV, Hematologic Malignancies
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...
Background: People living with HIV(PLWH) are at a higher risk for cancers that may be curable with a bone marrow transplant. HIV infection itself is no longer a reason to not get a transplant, for patients who otherwise have a…
- Trial name
- NCT05470491
- Testing
- RIC, GVHD prophylaxis, allo HCT
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Dermoid Cyst, Choristomas
Role of Alcohol in Prevention of Recurrence of the Accidentally Opened Angular Dermoid Cyst
Purpose to evaluate the effect of alcohol used in accidentally opened dermoid cyst in prevention of inflammation and recurrence Patient and method: Itt is a comparative interventional study ,performed on 60 patients with external…
- Trial name
- NCT06816316
- Testing
- external angular dermoid cysts surgical removal
- Where
- 3 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
TBI
Evaluation of Spot Light: A Concussion Injury Management App for Youth Sports
Sports-related traumatic brain injuries (TBIs), including mTBIs-commonly referred to as concussions-are a serious public health concern.
- Trial name
- SpotLight (NCT02249533)
- Testing
- Spot Light Concussion App
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Lara McKenzie
Urinary Tract Infection, Recurrent Urinary Tract Infection
Effects of Antibiotic Prophylaxis on Recurrent UTI in Children
Approximately, 3% of males and 8% of females will develop a urinary tract infection (UTI) during childhood, and most of these will be effectively treated by short-term antibiotic therapy.
- Trial name
- NCT02357758
- Testing
- Antibiotic Prophylaxis
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obesity, Child, Only
Healthy Caregivers-Healthy Children
The purpose of the study is to further develop and examine the Health Caregivers Healthy Children (HC2) program, which encourages obesity prevention through promoting healthy eating and physical activity.
- Trial name
- HC3 (NCT05106426)
- Testing
- Healthy Caregivers- Healthy children, Jump Start
- Where
- United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cardiovascular Diseases
Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD
To investigate whether a long-term strategy to lower LDL cholesterol with atorvastatin as much as possible will improve prognosis in CHD patients compared with a strategy reflecting current best clinical practice with simvastatin.
- Trial name
- IDEAL (NCT00159835)
- Testing
- atorvastatin, simvastatin
- Where
- 194 sites in Denmark, Finland and 4 more
- Volunteers
- 8,600 people
- Sponsor
- Pfizer
Hereditary Angioedema, Pediatric
Berotralstat Treatment in Children With Hereditary Angioedema
The purpose of this study is to evaluate the pharmacokinetics (PK), safety and effectiveness of berotralstat to determine the appropriate weight-based dose for pediatric participants 2 to < 12 years of age for prophylactic…
- Trial name
- APeX-P (NCT05453968)
- Testing
- Berotralstat
- Where
- 15 sites in Austria, Canada and 8 more
- Volunteers
- 29 people
- Sponsor
- BioCryst Pharmaceuticals
Hodgkin Lymphoma in Remission, Leukemia in Remission
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment.
- Conditions
- Hodgkin Lymphoma in Remission, Leukemia in Remission, Lymphoblastic Lymphoma, Osteosarcoma
- Trial name
- NCT01790152
- Testing
- Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 79 sites in United States, Australia and 2 more
- Volunteers
- 420 people
- Sponsor
- Children's Oncology Group
Adolescent Behavior
Drug Use Prevention Among Girls Through a Mother-Daughter Intervention
This study will develop and test drug use prevention strategies for low-income, minority girls. Gender-specific substance use rates, risk and protective factors, and health outcomes highlight the need for interventions aimed at…
- Trial name
- NCT00310258
- Testing
- Drug use prevention intervention
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Public Health
Impact/Interest of a Collective Prevention Intervention in Sexual and Emotional Health
Main objective To measure the effects of a group prevention intervention on the sexual and affective knowledge of high school students in the Basse-Normandie region.
- Trial name
- Impex (NCT06400758)
- Testing
- questionary
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Pole Sante Grace de Dieu
Addiction Opiate
Comparison Between Different Psychotherapy Interventions Regarding Their Effect on Substance Craving
the study aim is to compare betwenn the effect of mindfulness based relapse prevention and other evidence based psychotherapy interventions regaring substance craving.
- Trial name
- NCT05256485
- Testing
- cognitive behavioral therapy,mindfulness based relapse prevention,twelve-step therapy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sara Harby
Post-Traumatic Seizure Disorder, Head Injuries
Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures
OBJECTIVES: I. Determine whether treating head injured patients with valproate sodium will reduce the risk of developing seizures as a result of the head injury. II.
- Trial name
- NCT00004817
- Testing
- phenytoin, valproate sodium
- Volunteers
- 385 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Glioma of Brain, Craniopharyngioma
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors
Children with brain tumors who have had radiation therapy are at risk for problems with attention, memory, and problem solving. Such problems may cause difficulty in school and daily life.
- Conditions
- Glioma of Brain, Craniopharyngioma, Ependymoma, Germ Cell Tumor
- Trial name
- NCT03194906
- Testing
- Memantine, Cognitive Assessment
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- St. Jude Children's Research Hospital
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