Clinical trials: Prophylaxis
Central Line-associated Bloodstream Infection (CLABSI)
Port Protectors for Prevention of CLABSIs in Respiratory Semi-intensive Care Unit
Central Line-Associated BloodStream Infections (CLABSIs) are responsible for many deaths in the United States annually. Several collaboratives have demonstrated the preventability of these infections.
- Trial name
- NCT03486093
- Testing
- Training and retraining to GAVECELT "bundle" recommendations plus port protector, Training and retraining to GAVECELT "bundle" recommendations
- Volunteers
- 132 people
- Sponsor
- Catholic University of the Sacred Heart
Sports Injury, Prevention
Evaluation of Invisible Preparation Behaviors of Middle and High School Students in Sports Facilities (PRICELESS)
The investigators define the Invisible Preparation (IP) as the set of health behaviors that young athletes implement, on their own, to optimize their health and performances.
- Conditions
- Sports Injury, Prevention, Training, Hydration
- Trial name
- PRICELESS (NCT06361771)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Depression
An Internet-based Program for Prevention and Early Intervention of Adolescent Depression
Major depression is a highly prevalent and severe mental disease. Interventions based on information and communication technologies (ICTs) generate innovative opportunities to prevent and to intervene early the depression in…
- Trial name
- NCT02780232
- Testing
- Cuida tu animo / Care for your mood
- Where
- 3 sites in Colombia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- CES University
Breast Cancer
Studying Cells Collected Through Ductal Lavage in Women Undergoing Surgery for Ductal Carcinoma In Situ or Other Breast Cancer
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00896857
- Testing
- RNA analysis, polymerase chain reaction, protein expression analysis
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
HIV, Sexually Transmitted Diseases
Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic
This study will determine whether showing an educational DVD to people at sexually transmitted infection clinics can reduce incidence of new infections and risky sexual behaviors and improve overall health.
- Conditions
- HIV, Sexually Transmitted Diseases, HIV Infections
- Trial name
- NCT00947271
- Testing
- DVD 1, DVD 2
- Where
- United States
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Haemophilia A
Turoctocog Alfa in Haemophilic Italian Patients: Protection and Engagement in Recreational Activities
This is a study on Italian patients with haemophilia A in prophylaxis treatment with Turoctocog alfa under routine clinical conditions.
- Trial name
- THIRd (NCT04584892)
- Testing
- Turoctocog alfa
- Where
- 10 sites in Italy
- Volunteers
- 18 people
- Sponsor
- Novo Nordisk A/S
Injuries
Fuzzy AI Using VR for Collision Prevention
The purpose of this study is to develop and test a VR training system that integrates GFT AI with virtual obstacle scenarios that, when compared to a sham-VR training system, is hypothesized to increase neuromechanical and…
- Trial name
- CAT (NCT03915119)
- Testing
- GFT AI training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pre-myopia
Evaluation of Contact Lenses and Myopia.
This study will evaluate the effect of dual focus contact lenses on Myopia prevention.
- Trial name
- NCT07566234
- Testing
- Test Lens - Dual Focus
- Where
- China
- Volunteers
- 110 people
- Sponsor
- CooperVision International Limited (CVIL)
Dental Caries Prevention
Silver Nanoparticle vs Chlorhexidine Mouthwashes for Reducing Streptococcus Mutans and Improving Salivary pH in Children
Dental caries remains one of the most common chronic diseases in children, with Streptococcus mutans playing a major role in its development.
- Trial name
- SMILE (NCT07728409)
- Testing
- Silver nanoparticle mouthwash (10 ppm), Chlorhexidine mouthwash (0.2%)
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Body Dysmorphic Disorders
Internet-delivered Cognitive-behaviour Therapy for Child and Adolescent Body Dysmorphic Disorder
The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the 6-month durability of a therapist-guided, Internet-delivered cognitive-behavior therapy programme for children and adolescents with…
- Trial name
- NCT06262412
- Testing
- Internet-delivered cognitive-behaviour therapy (ICBT), Internet-delivered relaxation treatment (IRT)
- Where
- 3 sites in Sweden
- Volunteers
- 154 people
- Sponsor
- Karolinska Institutet
Acceptability of Health Care, Adherence, Medication
Project Engage: Oral PrEP Acceptability
This study is a two-arm open label acceptability study that will examine acceptability of, and adherence to, once daily dosing regimen of F/TDF (Truvada) and an investigational once daily dosing regimen of F/TAF (Descovy) under…
- Trial name
- NCT05458765
- Testing
- emtricitabine/tenofovir alafenamide, Emtricitabine / Tenofovir Disoproxil Oral Tablet
- Where
- 3 sites in South Africa, Zimbabwe
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Tobacco, Prevention
Education Against Tobacco Randomized Trial
A two armed randomized trial is evaluating the effect of the medical-student-delivered school-based intervention Education Against Tobacco on the smoking behavior of adolescents in 7th grade of secondary school.
- Conditions
- Tobacco, Prevention, Adolescents, Schools
- Trial name
- NCT02697409
- Testing
- Education Against Tobacco intervention
- Where
- Germany
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Cancer
The SUNRISE Project is Dedicated to Enhancing Primary Cancer Prevention Among Adolescents in Europe by Leveraging Innovative Digital Tools and Methodologies. SmartCoach, Developed by Swiss Research Institute for Public Health and Addiction (ISGF), is a Mobile Phone-based Life-skills Training Program
SUNRISE aims to create a comprehensive, engaging, and sustainable digital health promotion program that not only addresses immediate health behaviours but also instills lifelong healthy habits among adolescents.
- Trial name
- SUNRISE_1 (NCT06922201)
- Testing
- SmartCoach
- Where
- 8 sites in Belgium, Cyprus and 6 more
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Biobizkaia Health Research Institute
Excessive Absenteeism by Primary School Students
The Early Truancy Prevention Project
The Early Truancy Prevention Project is designed to prevent elementary school truancy through teacher-led interventions that are individualized to meet student needs.
- Trial name
- ETPP (NCT01894464)
- Testing
- Teacher led intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Omphalitis, Septicaemia
Efficacy of Umbilical Cord Cleansing With a Single Application of 4% Chlorhexidine for the Prevention of Newborn Infections in Uganda: a Randomized Controlled Trial
Background: Nearly all the yearly 3.3 million neonatal deaths occur in low and middle income countries. Infections, including those affecting the umbilical cord (omphalitis) are a significant factor in approximately a third of…
- Trial name
- NCT02606565
- Testing
- Intervention arm: 4% chlorhexidine
- Where
- Uganda
- Volunteers
- 4,760 people, healthy volunteers welcome
- Sponsor
- Makerere University
EHLERS-DANLOS SYNDROME, TYPE IV, AUTOSOMAL DOMINANT, CHROMOSOME 2q31.2 DELETION SYNDROME
Celiprolol in Patients With Ehlers-Danlos Syndrome, Vascular Type
Ehlers-Danlos syndrome vascular type (EDS-IV) is caused by a genetic defect of collagen type III. Patient die (median 40 yrs) of vascular complications. There is no treatment.
- Trial name
- NCT00190411
- Testing
- celiprolol, Control
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hereditary Angioedema (HAE)
Post Study Access of CSL312 (Garadacimab) for Pediatric Participants With Hereditary Angioedema Who Have Completed the CSL312_3003 Study
This protocol for post study access allows pediatric participants (2-11 years old at the time of consent) with HAE who have completed study CSL312_3003 (NCT05819775) to continue treatment with CSL312 for routine prevention of HAE…
- Trial name
- NCT07159464
- Testing
- CSL312
- Sponsor
- CSL Behring
Myopia
AI-Stratified Myopia Control for Children in Remote Areas
This cluster-randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of an artificial intelligence-based, risk-stratified, tiered intervention model for childhood myopia prevention and control in…
- Trial name
- NCT07825428
- Testing
- Routine Screening and Referral, AI-Guided Tiered Management
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Overweight and Obesity
Prevention and Intervention of Overweight and Obesity in Preschool Children
Obesity is an important public health problem, which is directly related to the risk of childhood complications and the increase of incidence rate and mortality of adult complications.
- Trial name
- NCT06562465
- Testing
- dietary and exercise management, no dietary and exercise management
- Where
- 2 sites in China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Chen Li
Healthy Subjects, Sports Level 1
Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention
The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman.
- Trial name
- NCT05951036
- Testing
- Low-load Blood Flow Restriction training, High-load Eccentric training
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Udayana University
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