Clinical trials: Prophylaxis
Severe Hemophilia A
Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Subjects With Severe Hemophilia A
The primary objectives of this study are: to evaluate the safety and tolerability of rFVIIIFc administered as a prophylaxis (Arm 1), weekly (Arm 2), on-demand (Arm 3), and surgical treatment regimen; to evaluate the efficacy of…
- Trial name
- NCT01181128
- Testing
- Factor VIII (rFVIIIFc), Advate®
- Where
- 64 sites in United States, Australia and 17 more
- Volunteers
- 165 people
- Sponsor
- Bioverativ Therapeutics Inc.
Retinopathy of Prematurity (ROP)
Long-term Safety and Efficacy Outcome Study Comparing Children Previously Enrolled in Study ROPP-2008-01 for the Prevention of Retinopathy of Prematurity (ROP)
The main purpose of this study is to evaluate the long-term efficacy and safety outcomes following short-term exposure to rhIGF-1/rhIGFBP-3 versus standard neonatal care in Study ROPP-2008-01 (NCT01096784).
- Trial name
- PEDAL (NCT02386839)
- Testing
- rhIGF-1/rhIGFBP-3
- Where
- 16 sites in United States, Italy and 4 more
- Volunteers
- 76 people
- Sponsor
- Shire
Preterm Birth
E-health-supported Diagnostic and Intervention in Preterm Born Children and Their Families
The app-based diagnostic and support approach with a focus on mental and somatic symptoms is intended to strengthen the resilience of premature born children and families and to identify risk and resilience factors.The overall…
- Trial name
- NeoUp2 (NCT06939192)
- Testing
- Intervention Group (APP), Treatment as usual-Group (TAU)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Strabismus
Peribulbar Block for Prevention of Oculocardiac Reflex
Strabismus is a common ophthalmic problem in Egypt that usually requires surgical correction. This surgery primarily aims to improve alignment of visual axis but may be required only for cosmetic reasons.
- Trial name
- NCT04549844
- Testing
- Bupivacaine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Gambling, Pathological Gambling
Indicated Prevention With At-Risk Gamblers
The overall purpose of this study is to reduce the prevalence of gambling risk in college students by evaluating the effectiveness of different treatments in reducing gambling behavior and related negative consequences.
- Conditions
- Gambling, Pathological Gambling, Problem Gambling
- Trial name
- NCT00078273
- Testing
- Personalized Feedback Intervention, Cognitive Behavioral Intervention
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of Washington
Smoking Cessation, Coronary Artery Disease
Cytisine Compared to Combination NRT in Relapsed Smokers
Cigarette smoking causes cardiovascular disease (CVD) yet many smokers with CVD are unable to quit despite strong desire to do so.
- Trial name
- CYTvsNRT+ (NCT04286295)
- Testing
- Cytisine, Nicoderm C-Q Transdermal Product, Nicorette Lozenge Product
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Upper Respiratory Infections, Influenza
Effectiveness of a Handwashing Programme in the Prevention of School Absenteeism Due to Respiratory Infections
The aim of the study was to assess the effectiveness of a hand-washing programme using hand sanitizer in the prevention of school absenteeism due to upper respiratory infections.
- Conditions
- Upper Respiratory Infections, Influenza, Common Cold
- Trial name
- NCT01728090
- Testing
- hand sanitizer
- Volunteers
- 1,640 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Mucositis Oral
A Clinical Trial of the Administration of Light Therapy to Prevent Mouth Sores in Children With Cancer
The goal of this clinical trial is to learn if light therapy can prevent mouth sores in children with cancer. The main questions it aims to answer are: Is it reasonable and acceptable to provide light therapy for children with…
- Trial name
- PBM (NCT06623305)
- Testing
- Photobiomodulation for prevention arm, Photobiomodulation for exploratory arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Schizophrenia Spectrum Disorders (SSD)
Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention
The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults…
- Trial name
- NCT07743645
- Testing
- Psychosocial intervention group
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Infections, Sexually Transmitted Diseases
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directed by the clinic.
- Trial name
- PCORI PrEP (NCT04855773)
- Testing
- PrEPmate, Dot Diary
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Adolescent Behavior, Lifestyle Modification
A Family-centred Approach Enhancing Cardiovascular Health in Ugandan Adolescents and Their Families
The FaCe-D Study, with funding from the Canadian Institute for Health Research (CIHR) through Global Alliance for Chronic Diseases (GACD) aims to adapt and implement an evidence-based family centred approach (FCA) to prevent…
- Conditions
- Adolescent Behavior, Lifestyle Modification, Cardiovascular Disease Other
- Trial name
- FaCe-D (NCT07265453)
- Testing
- The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING, Control Arm - standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Acute Respiratory Tract Infections, Respiratory Infection Prevention
Effectiveness of Education on Preventive Measures Against Acute Respiratory Tract Infections in School-Age Children
This study aimed to evaluate the effectiveness of an animation video-supported education program on preventive measures against acute respiratory tract infections among first-grade primary school children.
- Conditions
- Acute Respiratory Tract Infections, Respiratory Infection Prevention, Hand Hygiene, Respiratory Hygiene
- Trial name
- NCT07654712
- Testing
- Animation Video-Supported Education on Preventive Measures Against Acute Respiratory Tract Infections
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Haemophilia A
TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia
Haemophilic arthropathy is one of the major complications of severe haemophilia. In order to maintain plasma clotting factor activity levels above 1% and avoid spontaneous joint bleeds and other serious bleeding events…
- Trial name
- HOPE (NCT02781766)
- Testing
- Thrombin generation measurement.
- Where
- 7 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Men or Transgender Women Who Have Sex With Men
HIV Self-Testing AND Uptake and Retention of PrEP Among Older Adolescent MSM and TGW
This will be a prospective study that will enroll up to 600 older adolescent MSM and TGW from community-based clinics in Bangkok, Chonburi, Chiang Mai, and Songkhla.
- Trial name
- NCT03745495
- Where
- 7 sites in Thailand
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
COVID-19
A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19
The purpose of this double-blind, randomized, controlled study is to evaluate the efficacy, immunogenicity, reactogenicity and safety of an adjuvanted recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
- Trial name
- SCB-2019 (NCT04672395)
- Testing
- CpG 1018/Alum-adjuvanted SCB-2019 vaccine, SCB-2019 vaccine
- Where
- 31 sites in Belgium, Brazil and 3 more
- Volunteers
- 31,454 people, healthy volunteers welcome
- Sponsor
- Clover Biopharmaceuticals AUS Pty
Deep Venous Thrombosis
Low Molecular Weight Heparin vs Direct Oral Anticoagulant After Bariatric Surgery
Extended Venous Thromboemboism Prophylaxis After Bariatric Surgeries: A Comparison Of Low Molecular Weight Heparin With Direct Oral Anticoagulant
- Trial name
- NCT06913595
- Testing
- Direct Oral Anticoagulant., Low Molecular Weight Heparine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Gambling
Evaluation of Effectiveness of the Unplugged Program on Gambling Among Adolescents (GAPUnplugged)
The main aim of this study is to assess the effectiveness of a new component on gambling prevention to be added to the evidence-based school based prevention curriculum "Unplugged".
- Trial name
- GAPUnplugged (NCT05630157)
- Testing
- Unplugged plus gambling component
- Volunteers
- 3,046 people, healthy volunteers welcome
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Pre-Exposure Prophylaxis of HIV Infection
Pre-Exposure Prophylaxis Study of Lenacapavir in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People at Risk for HIV Infection
The goal of this study is to evaluate the efficacy of the study drugs, lenacapavir (LEN) in preventing HIV infection, in participants ≥ 16 years of age who have condomless receptive anal sex with partners assigned male at birth…
- Trial name
- PURPOSE 2 (NCT04925752)
- Testing
- Oral Lenacapavir (LEN), F/TDF, Sub-cutaneous (SC) Lenacapavir (LEN)
- Where
- 93 sites in United States, Argentina and 6 more
- Volunteers
- 3,292 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Children, Overweight
The Odense Overweight Intervention Study
Strong and consistent evidence have shown that overweight, including obesity, is an important risk factor for the development of cardiovascular disease (CVD) in adults.
- Conditions
- Children, Overweight, Obesity, Metabolic Syndrome
- Trial name
- OOIS (NCT01574352)
- Testing
- Small intervention, Intervention camp
- Where
- 2 sites in Denmark
- Volunteers
- 115 people
- Sponsor
- University of Southern Denmark
Dental Caries
Effect of Educational Intervention in Mothers for Prevention of Caries in Their Children
The purpose of this study is to determine the effect of an educational intervention on mothers knowledge, attitudes and practices for preventing childhood caries.
- Trial name
- NCT01763138
- Testing
- oral health education, reminder phone call
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
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