Clinical trials: Prostaglandin E2
Labour Induction
Oral Misoprostol Versus Vaginal Dinoprostone For Induction Of Labour: A Randomized Controlled Clinical Trial
This study is to compare between oral misoprostol in solution and vaginal dinoprostone in induction of labour in primiparous women with singleton pregnancy as regards efficiency and safety to both mother and fetus.
- Trial name
- NCT02168881
- Testing
- Misoprostol, Dinoprostone
- Where
- Egypt
- Volunteers
- 342 people
- Sponsor
- Ain Shams University
Hysteroscopy
Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Primarily Infertile Patients
To compare the effectiveness of vaginal dinoprostone with placebo in minimizing the pain experienced by primarily infertile patients during diagnostic office hysteroscopy and to assess the ease of insertion of hysteroscope as…
- Trial name
- NCT04042974
- Testing
- vaginal dinoprostone
- Volunteers
- 100 people
- Sponsor
- Cairo University
Failed Induction of Labor
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term
The purpose of this study is to compare concurrent oxytocin with membrane sweeping versus dinoprostone pessary in labor induction for multiparas at term with an unfavorable cervix.
- Trial name
- NCT02618096
- Testing
- Oxytocin, Dinoprostone, Membrane sweeping
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Failed Induction of Labor
Foley Catheter Versus Dinoprostone Vaginal Insert for Induction of Labor in Parous Women at Term: A Randomized Trial
The purpose of this study is to assess the effectiveness and safety of transcervical foley catheter as compared to dinoprostone vaginal insertion for preinduction cervical ripening and labor induction in term parous women with…
- Trial name
- NCT01596296
- Testing
- Transcervical foley catheter, Dinoprostone 10mg
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Preeclampsia, Fetal Death
Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies
Hypothesis (H0): Labor duration and obstetric complications are not significantly different in the three groups (misoprostol-dinoprostone-oxytocin).
- Conditions
- Preeclampsia, Fetal Death, Fetal Membranes, Premature Rupture
- Trial name
- NCT00432588
- Testing
- misoprostol, dinoprostone
- Where
- Iran
- Sponsor
- Hormozgan University of Medical Sciences
Obesity, Pregnancy
Randomized Controlled Trial: Induction of Labour of Obese Women With Dinoprostone or Single Balloon Catheter
The purpose of this study is to compare the efficacy of single balloon foley catheters to dinoprostone for the induction of labour of obese women.
- Conditions
- Obesity, Pregnancy, Labor, Induced
- Trial name
- NCT01962831
- Testing
- Dinoprostone, Single balloon foley catheter
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Myomectomy
Intravenous Tranexamic Acid Versus Vaginal Dinoprostone in Abdominal Myomectomy
the aim of the present study is to evaluate safety and efficacy of intravenous tranexamic acid versus vaginal dinoprostone in reducing intraoperative blood loss during abdominal myomectomy
- Trial name
- NCT04357002
- Testing
- intravenous tranexamic acid, vaginal dinoprostone
- Volunteers
- 180 people
- Sponsor
- Cairo University
Contraception
Comparative Safety and Efficacy of Vaginal Dinoprostone Versus Lidocaine-prilocaine Cream in Copper IUD Insertion
the aim of the present study is to Compare Safety and Efficacy of Vaginal dinoprostone Versus Lidocaine-prilocaine Cream in copper IUD Insertion in nulliparous women: a randomized controlled trial
- Trial name
- NCT04340778
- Testing
- vaginal dinoprostone, Lidocaine-prilocaine Cream
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cairo University
Contraception
Comparative Efficacy of Lidocaine Spray Versus Vaginal Dinoprostone in IUD Insertion
the aim of this study is to compare the safety and Efficacy of Lidocaine Spray Versus Vaginal dinoprostone in relieving pain during levonorgestrel IUD Insertion in nulliparous women
- Trial name
- NCT04339361
- Testing
- lidocaine spray, vaginal dinoprostone
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Induction of Labor Affected Fetus / Newborn
An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt
Induction of labour (where labour is started artificially) is traditionally carried out with a range of different drugs or by surgery (rupturing the membranes or 'waters').
- Trial name
- SOLVE (NCT03001661)
- Testing
- Dilapan-S, Dinoprostone
- Where
- United Kingdom
- Volunteers
- 674 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Induction of Labour
Trial Of Misoprostol And Dinoprostone Vaginal Pessaries for Cervical Priming (TROMAD Study)
Most studies of labour induction with misoprostol used doses higher than 25mg and intervals of 3-4 hours. We studied a low-dose regime of 25mg misoprostol and compared its efficacy as single dose or double dose with dosing…
- Trial name
- NCT00299754
- Testing
- Misoprostol
- Where
- Singapore
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Induction of Labour, Labour, Induced
Misoprostol Labour Induction Study
Labour induction is a frequent obstetric intervention (~20%). Prostaglandins (PGs) are effective agents, but gastrointestinal (GI) intolerance has limited use to non-oral routes.
- Trial name
- NCT03489928
- Testing
- Oral Misoprostol, Vaginal Misoprostol, Dinoprostone
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- David Young
Medical Induction of Labor Affecting Fetus
Titrated Oral Misoprostol Compared to Vaginal Dinoprostone for Induction of Labor
To test the safety and efficacy of titrated oral misoprostol compared to vaginal dinoprostone for labor induction.
- Trial name
- NCT02036437
- Testing
- Misotac® Sigma Pharmaceutical Industries, Dinoprostone 3 mg
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Induction of Labor Affected Fetus / Newborn, Prostaglandins Causing Adverse Effects in Therapeutic Use
Induction of Labor in Term Pregnancies With Unfavourable Cervix
This is a prospective randomized trial comparing two prostaglandin E2 (dinoprostone) agents used for labor induction in pregnant women with term pregnancies and unfavorable cervix.
- Trial name
- RAND (NCT04280874)
- Testing
- Dinoprostone 0.5 MG, Dinoprostone 2 MG/2.5 ML Vaginal Gel/Jelly
- Where
- Croatia
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Merkur
Eczema
PGE2/IL-22 Pathway in Various Forms of Eczema
Objectives: Eczema is a chronic inflammatory skin condition characterised immunologically by T cellmediated inflammation. The pathogenic mechanisms involved in its development are incompletely understood and targeted treatment…
- Trial name
- NCT04133506
- Testing
- Aspirin 300mg
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Facial Pain
Celebrex for Pain Relief After Oral Surgery
This study will evaluate the effects of the new anti-inflammatory drug, Celebrex, on relieving pain after oral surgery. It is also designed to assess the drug's selective inhibition of a chemical called cyclooxygenase-2 and not…
- Trial name
- NCT00006299
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Premature Rupture of Membranes at Term
Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
The purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal PGE2 gel application in women with premature rupture of membranes at…
- Trial name
- NCT00355303
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 932 people
- Sponsor
- Nilratan Sircar Medical College
Premature Newborns, Premature Newborns With Gestational Age 28 to 33 Weeks
Role of Interleukin-1β and Prostaglandin E2 in Prediction and Outcome of Apnea in Neonates
Our thesis proposed that IL-1β may affect brainstem respiratory control via prostaglandin-dependant mechanism so we investigated the mediator roles of IL-1β and PGE2 levels in predicting apnea in pretertm newborn and their…
- Trial name
- NCT06827197
- Testing
- Blood test
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Nulliparous Women Who Scheduled for Labor Induction
Concurrent Membrane Sweeping With Dinoprostone Versus Dinoprostone in Labor Induction of Nulliparas at Term With an Unfavorable Cervix
To compare concurrent membrane sweeping with dinoprostone versus dinoprostone in labor induction for nulliparas at term with an unfavorable cervix
- Trial name
- NCT01792375
- Testing
- Concurrent membrane sweeping with Dinoprostone, 10mg Dinoprostone vaginal insert
- Where
- South Korea
- Volunteers
- 192 people
- Sponsor
- Seoul National University Hospital
IUD Insertion Pain
Dinoprostone vs Misoprostol Before LNG-IUD Insertion
the aim of this study is to compare the safety and efficacy of vaginal dinoprostone vs vaginal misoprostol administration prior to IUD insertion in multiparous women regarding reduction in iud insertion pain
- Trial name
- NCT04301349
- Testing
- vaginal dinoprostone, vaginal misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University